دورية أكاديمية
أعرض في EDS

Purple sweet potato (Ipomoea batatas L.) extract effects on levels of inflammatory markers and chondrocyte count in gout arthritis Wistar rat model.

التفاصيل البيبلوغرافية
العنوان: Purple sweet potato (Ipomoea batatas L.) extract effects on levels of inflammatory markers and chondrocyte count in gout arthritis Wistar rat model.
المؤلفون: Subawa IW; Dept. Orthopaedic & Traumatology, Prof dr IGNG Ngoerah General Hospital, Faculty of Medicine, Udayana University, Bali, Indonesia. Electronic address: iwayansubawa1976@gmail.com., Astawa P; Dept. Orthopaedic & Traumatology, Prof dr IGNG Ngoerah General Hospital, Faculty of Medicine, Udayana University, Bali, Indonesia., Bakta IM; Dept. Internal Medicine, Prof dr IGNG Ngoerah General Hospital, Faculty of Medicine, Udayana University, Bali, Indonesia., Astawa INM; Faculty of Veterinary Medicine, Udayana University, Bali, Indonesia., Krisna GA; Dept. Orthopaedic & Traumatology, Prof dr IGNG Ngoerah General Hospital, Faculty of Medicine, Udayana University, Bali, Indonesia.
المصدر: Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons [Foot Ankle Surg] 2023 Dec; Vol. 29 (8), pp. 611-615. Date of Electronic Publication: 2023 Jul 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: France NLM ID: 9609647 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-9584 (Electronic) Linking ISSN: 12687731 NLM ISO Abbreviation: Foot Ankle Surg Subsets: MEDLINE
أسماء مطبوعة: Publication: [London] : Elsevier Ltd.
Original Publication: Paris : Arnette Blackwell, c1996-
مواضيع طبية MeSH: Ipomoea batatas*/metabolism , Gout*, Rats ; Animals ; Humans ; Rats, Wistar ; Matrix Metalloproteinase 3/metabolism ; Chondrocytes ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plant Extracts/metabolism
مستخلص: Background: Recently, herbal medicine has become alternative in management of gout. Our aim is to assess effectiveness of purple sweet potato extract in gout.
Method: In vivo study with randomized posttest only control group design. Purple sweet potato extract administered to 16 Wistar rats with MSU-induced gout. Independent t-test for analyzing interleukin-1 β (IL-1β), matrix metalloproteinase-3 (MMP-3), cartilage oligomeric matrix protein (COMP), malondialdehyde (MDA), and number of chondrocytes results.
Results: Decreased level of IL-1β (3.81 ± 1.54 ng/mL vs. 2.55 ± 0.59 ng/mL, p = 0.04), MDA (5.04 ± 1.02 ng/mL vs. 2.27 ± 0.57 ng/mL, p = 0.04), MMP-3 (5.66 ± 1.02 ng/mL vs. 3.84 ± 1.37 ng/mL, p = 0.01) COMP (21.01 ± 3.57 ng/mL vs. 17.27 ± 2.60 ng/mL, p = 0.03), and increasing chondrocytes (35.17 ± 12.35 lp vs. 48.56 ± 7.17 lp, p = 0.02).
Conclusion: Purple sweet potato extract with anthocyanin inhibits inflammation and cartilage degeneration in gout.
Level of Evidence: Level 1.
Competing Interests: Declaration of Competing Interest There are no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier Ltd.)
فهرسة مساهمة: Keywords: Articular cartilage; Gout; Inflammation; Ipomoea batatas L.; Purple sweet potato
المشرفين على المادة: EC 3.4.24.17 (Matrix Metalloproteinase 3)
0 (Plant Extracts)
تواريخ الأحداث: Date Created: 20231112 Date Completed: 20231201 Latest Revision: 20231201
رمز التحديث: 20240628
DOI: 10.1016/j.fas.2023.07.007
PMID: 37953101
قاعدة البيانات: MEDLINE
الوصف
تدمد:1460-9584
DOI:10.1016/j.fas.2023.07.007