دورية أكاديمية
أعرض في EDS

Inter-generational nuclear crosstalk links the control of gene expression to programmed genome rearrangement during the Paramecium sexual cycle.

التفاصيل البيبلوغرافية
العنوان: Inter-generational nuclear crosstalk links the control of gene expression to programmed genome rearrangement during the Paramecium sexual cycle.
المؤلفون: Bazin-Gélis M; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France., Eleftheriou E; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France.; Institut Pasteur, Université Paris Cité, Inserm U1223, Innate Immunity Unit, Paris, France., Zangarelli C; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France., Lelandais G; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France., Sperling L; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France., Arnaiz O; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France., Bétermier M; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France.
المصدر: Nucleic acids research [Nucleic Acids Res] 2023 Dec 11; Vol. 51 (22), pp. 12337-12351.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 1992- : Oxford : Oxford University Press
Original Publication: London, Information Retrieval ltd.
مواضيع طبية MeSH: Paramecium tetraurelia*/cytology , Paramecium tetraurelia*/genetics, Gene Expression ; Gene Rearrangement ; Genome ; Macronucleus
مستخلص: Multinucleate cells are found in many eukaryotes, but how multiple nuclei coordinate their functions is still poorly understood. In the cytoplasm of the ciliate Paramecium tetraurelia, two micronuclei (MIC) serving sexual reproduction coexist with a somatic macronucleus (MAC) dedicated to gene expression. During sexual processes, the MAC is progressively destroyed while still ensuring transcription, and new MACs develop from copies of the zygotic MIC. Several gene clusters are successively induced and switched off before vegetative growth resumes. Concomitantly, programmed genome rearrangement (PGR) removes transposons and their relics from the new MACs. Development of the new MACs is controlled by the old MAC, since the latter expresses genes involved in PGR, including the PGM gene encoding the essential PiggyMac endonuclease that cleaves the ends of eliminated sequences. Using RNA deep sequencing and transcriptome analysis, we show that impairing PGR upregulates key known PGR genes, together with ∼600 other genes possibly also involved in PGR. Among these genes, 42% are no longer induced when no new MACs are formed, including 180 genes that are co-expressed with PGM under all tested conditions. We propose that bi-directional crosstalk between the two coexisting generations of MACs links gene expression to the progression of MAC development.
(© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.)
References: PLoS Genet. 2014 Sep 25;10(9):e1004665. (PMID: 25254958)
PLoS Pathog. 2023 Feb 2;19(2):e1011087. (PMID: 36730159)
PLoS Genet. 2020 Jul 23;16(7):e1008949. (PMID: 32702045)
PLoS Genet. 2011 Apr;7(4):e1002049. (PMID: 21533177)
Nucleic Acids Res. 2018 Oct 12;46(18):9550-9562. (PMID: 30165457)
Nature. 2011 Jan 20;469(7330):343-9. (PMID: 21248841)
Curr Opin Genet Dev. 2014 Aug;27:26-34. (PMID: 24886889)
Semin Cell Dev Biol. 2021 Dec;120:10-21. (PMID: 34642103)
Genet Res. 1976 Apr;27(2):227-38. (PMID: 1278685)
PLoS Genet. 2012;8(10):e1002984. (PMID: 23071448)
Mol Cell Biol. 2003 Oct;23(20):7152-62. (PMID: 14517286)
Eukaryot Cell. 2010 Jul;9(7):1087-99. (PMID: 20495055)
BMC Bioinformatics. 2011 Jan 26;12:35. (PMID: 21269502)
Cell Rep. 2017 Jul 11;20(2):505-520. (PMID: 28700949)
Elife. 2018 Sep 18;7:. (PMID: 30223944)
Immunity. 1995 Nov;3(5):601-8. (PMID: 7584150)
EMBO J. 2022 Nov 17;41(22):e111839. (PMID: 36221862)
Biochim Biophys Acta Mol Cell Res. 2022 Jun;1869(6):119239. (PMID: 35181406)
Bioinformatics. 2011 Apr 1;27(7):1017-8. (PMID: 21330290)
Development. 2022 Nov 1;149(21):. (PMID: 36305464)
Nat Rev Microbiol. 2003 Nov;1(2):117-26. (PMID: 15035041)
Bioinformatics. 2016 Feb 15;32(4):599-601. (PMID: 26589276)
Database (Oxford). 2013 Mar 12;2013:bat008. (PMID: 23482072)
Curr Biol. 2005 Sep 20;15(18):1616-28. (PMID: 16169483)
Genes Dev. 2023 Aug 1;37(15-16):703-723. (PMID: 37673459)
Eukaryot Cell. 2003 Oct;2(5):1076-90. (PMID: 14555491)
Nucleic Acids Res. 2020 Jan 8;48(D1):D599-D605. (PMID: 31733062)
Genome Biol. 2014;15(12):550. (PMID: 25516281)
Mol Cell Biol. 2000 Mar;20(5):1553-61. (PMID: 10669733)
Fac Rev. 2022 Dec 23;11:40. (PMID: 36644296)
Biol Cell. 1994;81(2):95-119. (PMID: 7531532)
DNA Repair (Amst). 2019 May;77:96-108. (PMID: 30928893)
Trends Genet. 2002 Jan;18(1):11-2. (PMID: 11750689)
Microbiol Rev. 1994 Jun;58(2):233-67. (PMID: 8078435)
Nature. 2006 Nov 9;444(7116):171-8. (PMID: 17086204)
Nat Rev Mol Cell Biol. 2021 Dec;22(12):815-833. (PMID: 34400841)
BMC Genomics. 2017 Jun 26;18(1):483. (PMID: 28651633)
Cell Rep. 2022 Aug 23;40(8):111263. (PMID: 36001962)
Mol Biol Cell. 2016 Jul 1;27(13):2000-7. (PMID: 27193301)
Cold Spring Harb Protoc. 2010 Jan;2010(1):pdb.prot5363. (PMID: 20150122)
Nat Commun. 2019 Jun 20;10(1):2710. (PMID: 31221974)
Nucleic Acids Res. 2009 Feb;37(3):903-15. (PMID: 19103667)
Nat Commun. 2020 Dec 11;11(1):6374. (PMID: 33311464)
Chromosoma. 1973 Jun 28;42(3):247-68. (PMID: 4354261)
Cold Spring Harb Protoc. 2010 Jan;2010(1):pdb.prot5362. (PMID: 20150121)
J Eukaryot Microbiol. 2022 Sep;69(5):e12914. (PMID: 35363910)
Nucleic Acids Res. 1995 Jun 11;23(11):2006-13. (PMID: 7596830)
PLoS One. 2012;7(2):e30630. (PMID: 22347391)
Dev Cell. 2022 Apr 25;57(8):1037-1052.e8. (PMID: 35429435)
Genet Res. 1976 Apr;27(2):123-34. (PMID: 1278677)
PLoS Genet. 2014 Aug 28;10(8):e1004552. (PMID: 25166013)
Trends Cell Biol. 2020 Feb;30(2):87-96. (PMID: 31818700)
Curr Top Dev Biol. 2015;113:85-112. (PMID: 26358871)
Dev Biol. 2022 Apr;484:75-87. (PMID: 35182536)
PLoS Genet. 2020 Apr 16;16(4):e1008723. (PMID: 32298257)
Nucleic Acids Res. 2017 Apr 7;45(6):3204-3216. (PMID: 28104713)
Dev Cell. 2014 Jan 27;28(2):174-88. (PMID: 24439910)
Genes Dev. 2008 Jun 1;22(11):1501-12. (PMID: 18519642)
Gene. 2001 Jan 24;263(1-2):103-12. (PMID: 11223248)
Genes (Basel). 2020 Mar 31;11(4):. (PMID: 32244282)
PLoS One. 2014 Nov 14;9(11):e112899. (PMID: 25397898)
Mol Cell Biol. 2004 Sep;24(17):7370-9. (PMID: 15314149)
Genes Dev. 2009 Nov 1;23(21):2478-83. (PMID: 19884254)
PLoS Genet. 2015 Jul 15;11(7):e1005383. (PMID: 26177014)
Bioinformatics. 2021 Sep 29;37(18):2834-2840. (PMID: 33760053)
Microbiol Spectr. 2014 Dec;2(6):. (PMID: 26104450)
Nat Commun. 2020 Dec 11;11(1):6375. (PMID: 33311457)
PLoS Biol. 2021 Jul 29;19(7):e3001309. (PMID: 34324490)
Science. 1989 Jan 27;243(4890):507-12. (PMID: 2536191)
Genome Res. 2022 Nov-Dec;32(11-12):2028-2042. (PMID: 36418061)
BMC Genomics. 2017 Apr 26;18(1):327. (PMID: 28446146)
NAR Genom Bioinform. 2020 Sep;2(3):lqaa078. (PMID: 33015620)
معلومات مُعتمدة: Centre National de la Recherche Scientifique; ANR-14-CE10-0005 Agence Nationale de la Recherche; FRM EQU202103012766 Fondation pour la Recherche Médicale; 577 SDSV Paris-Saclay University; Department of Genome Biology of I2BC; ANR-10-INBS-09 Investissement d'Avenir; ANR-11-EQPX-0029/Morphoscope Agence Nationale de la Recherche
تواريخ الأحداث: Date Created: 20231112 Date Completed: 20231220 Latest Revision: 20231220
رمز التحديث: 20231220
مُعرف محوري في PubMed: PMC10711438
DOI: 10.1093/nar/gkad1006
PMID: 37953377
قاعدة البيانات: MEDLINE
الوصف
تدمد:1362-4962
DOI:10.1093/nar/gkad1006