دورية أكاديمية
FLASH Radiotherapy: A FLASHing Idea to Preserve Neurocognitive Function.
| العنوان: | FLASH Radiotherapy: A FLASHing Idea to Preserve Neurocognitive Function. |
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| المؤلفون: | Jo HJ; College of Veterinary Medicine, Seoul National University, Seoul, Korea., Oh T; College of Veterinary Medicine, Seoul National University, Seoul, Korea., Lee YR; College of Veterinary Medicine, Seoul National University, Seoul, Korea., Kang GS; College of Veterinary Medicine, Seoul National University, Seoul, Korea., Park HJ; College of Veterinary Medicine, Seoul National University, Seoul, Korea., Ahn GO; College of Veterinary Medicine, Seoul National University, Seoul, Korea.; College of Medicine, Seoul National University, Seoul, Korea. goneahn@snu.ac.kr. |
| المصدر: | Brain tumor research and treatment [Brain Tumor Res Treat] 2023 Oct; Vol. 11 (4), pp. 223-231. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Korean Brain Tumor Society Country of Publication: Korea (South) NLM ID: 101627407 Publication Model: Print Cited Medium: Print ISSN: 2288-2405 (Print) Linking ISSN: 22882405 NLM ISO Abbreviation: Brain Tumor Res Treat Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Daegu : Korean Brain Tumor Society, [2013]- |
| مستخلص: | FLASH radiotherapy (FLASH RT) is a technique to deliver ultra-high dose rate in a fraction of a second. Evidence from experimental animal models suggest that FLASH RT spares various normal tissues including the lung, gastrointestinal track, and brain from radiation-induced toxicity (a phenomenon known as FLASH effect), which is otherwise commonly observed with conventional dose rate RT. However, it is not simply the ultra-high dose rate alone that brings the FLASH effect. Multiple parameters such as instantaneous dose rate, pulse size, pulse repetition frequency, and the total duration of exposure all need to be carefully optimized simultaneously. Furthermore it is critical to validate FLASH effects in an in vivo experimental model system. The exact molecular mechanism responsible for this FLASH effect is not yet understood although a number of hypotheses have been proposed including oxygen depletion and less reactive oxygen species (ROS) production by FLASH RT, and enhanced ability of normal tissues to handle ROS and labile iron pool compared to tumors. In this review, we briefly overview the process of ionization event and history of radiotherapy and fractionation of ionizing radiation. We also highlight some of the latest FLASH RT reviews and results with a special interest to neurocognitive protection in rodent model with whole brain irradiation. Lastly we discuss some of the issues remain to be answered with FLASH RT including undefined molecular mechanism, lack of standardized parameters, low penetration depth for electron beam, and tumor hypoxia still being a major hurdle for local control. Nevertheless, researchers are close to having all answers to the issues that we have raised, hence we believe that advancement of FLASH RT will be made more quickly than one can anticipate. Competing Interests: The authors have no potential conflicts of interest to disclose. (Copyright © 2023 The Korean Brain Tumor Society, The Korean Society for Neuro-Oncology, and The Korean Society for Pediatric Neuro-Oncology.) |
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| معلومات مُعتمدة: | RS-2022-00144495 Korea MSIT Ministry of Science and ICT, South Korea; RS-2023-00218623 Korea MSIT Ministry of Science and ICT, South Korea; NRF-2020M2D9A2092374 Korea MSIT Ministry of Science and ICT, South Korea; NRF-2021K1A3A1A17086250 Korea MSIT Ministry of Science and ICT, South Korea; A0449-20230100 Korea MOE Ministry of Education; Korea RIVS Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University |
| فهرسة مساهمة: | Keywords: Neurocognitive protection.; Radiotherapy; Ultra-high dose rate radiation |
| تواريخ الأحداث: | Date Created: 20231112 Latest Revision: 20231115 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10641319 |
| DOI: | 10.14791/btrt.2023.0026 |
| PMID: | 37953445 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2288-2405 |
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| DOI: | 10.14791/btrt.2023.0026 |