دورية أكاديمية
In Situ Spatial Reconstruction of Distinct Normal and Pathological Cell Populations Within the Human Adrenal Gland.
| العنوان: | In Situ Spatial Reconstruction of Distinct Normal and Pathological Cell Populations Within the Human Adrenal Gland. |
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| المؤلفون: | Fu R; RNA Biosciences Initiative and Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine at Colorado Anschutz Medical Campus Aurora, Aurora, CO 80045, USA.; Computational Biology, New York Genome Center, New York, NY 10013, USA., Walters K; RNA Biosciences Initiative and Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine at Colorado Anschutz Medical Campus Aurora, Aurora, CO 80045, USA., Kaufman ML; RNA Biosciences Initiative and Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine at Colorado Anschutz Medical Campus Aurora, Aurora, CO 80045, USA., Koc K; Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado School of Medicine at Colorado Anschutz Medical Campus Aurora, Aurora, CO 80045, USA., Baldwin A; RNA Biosciences Initiative and Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine at Colorado Anschutz Medical Campus Aurora, Aurora, CO 80045, USA., Clay MR; Department of Pathology, University of Colorado School of Medicine at Colorado Anschutz Medical Campus Aurora, Aurora, CO 80045, USA., Basham KJ; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA., Kiseljak-Vassiliades K; Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado School of Medicine at Colorado Anschutz Medical Campus Aurora, Aurora, CO 80045, USA.; Research Service Veterans Affairs Medical Center, Aurora, CO 80045, USA., Fishbein L; Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado School of Medicine at Colorado Anschutz Medical Campus Aurora, Aurora, CO 80045, USA., Mukherjee N; RNA Biosciences Initiative and Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine at Colorado Anschutz Medical Campus Aurora, Aurora, CO 80045, USA. |
| المصدر: | Journal of the Endocrine Society [J Endocr Soc] 2023 Oct 25; Vol. 7 (12), pp. bvad131. Date of Electronic Publication: 2023 Oct 25 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Endocrine Society Country of Publication: United States NLM ID: 101697997 Publication Model: eCollection Cited Medium: Internet ISSN: 2472-1972 (Electronic) Linking ISSN: 24721972 NLM ISO Abbreviation: J Endocr Soc Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : Endocrine Society, [2017]- |
| مستخلص: | The human adrenal gland consists of concentrically organized, functionally distinct regions responsible for hormone production. Dysregulation of adrenocortical cell differentiation alters the proportion and organization of the functional zones of the adrenal cortex leading to disease. Current models of adrenocortical cell differentiation are based on mouse studies, but there are known organizational and functional differences between human and mouse adrenal glands. This study aimed to investigate the centripetal differentiation model in the human adrenal cortex and characterize aldosterone-producing micronodules (APMs) to better understand adrenal diseases such as primary aldosteronism. We applied spatially resolved in situ transcriptomics to human adrenal tissue sections from 2 individuals and identified distinct cell populations and their positional relationships. The results supported the centripetal differentiation model in humans, with cells progressing from the outer capsule to the zona glomerulosa, zona fasciculata, and zona reticularis. Additionally, we characterized 2 APMs in a 72-year-old woman. Comparison with earlier APM transcriptomes indicated a subset of core genes, but also heterogeneity between APMs. The findings contribute to our understanding of normal and pathological cellular differentiation in the human adrenal cortex. (© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society.) |
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| معلومات مُعتمدة: | K08 CA222620 United States CA NCI NIH HHS; R01 CA246586 United States CA NCI NIH HHS; R35 GM147025 United States GM NIGMS NIH HHS |
| فهرسة مساهمة: | Keywords: RNA; adrenal cortex; primary aldosteronism; spatial transcriptomics; steroid hormones |
| تواريخ الأحداث: | Date Created: 20231113 Latest Revision: 20231218 |
| رمز التحديث: | 20231218 |
| مُعرف محوري في PubMed: | PMC10638100 |
| DOI: | 10.1210/jendso/bvad131 |
| PMID: | 37953901 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2472-1972 |
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| DOI: | 10.1210/jendso/bvad131 |