دورية أكاديمية
Review of Intra-Articular Use of Antibiotics and Antiseptic Irrigation and Their Systematic Association with Chondrolysis.
| العنوان: | Review of Intra-Articular Use of Antibiotics and Antiseptic Irrigation and Their Systematic Association with Chondrolysis. |
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| المؤلفون: | Post HK; Department of Orthopedic Surgery and Sports Medicine, University of Kansas School of Medicine, Kansas City, KS., Blankespoor MG; Department of Orthopedic Surgery and Sports Medicine, University of Kansas School of Medicine, Kansas City, KS., Ierulli VK; Department of Orthopaedic Surgery, Tulane University School of Medicine, New Orleans, LA., Morey TD; Department of Orthopedic Surgery and Sports Medicine, University of Kansas School of Medicine, Kansas City, KS., Schroeppel JP; Department of Orthopedic Surgery and Sports Medicine, University of Kansas School of Medicine, Kansas City, KS., Mulcahey MK; Department of Orthopaedic Surgery and Rehabilitation, Loyola University Medical Center, Maywood, IL., Vopat BG; Department of Orthopedic Surgery and Sports Medicine, University of Kansas School of Medicine, Kansas City, KS., Vopat ML; Department of Orthopedic Surgery and Sports Medicine, University of Kansas School of Medicine, Kansas City, KS. |
| المصدر: | Kansas journal of medicine [Kans J Med] 2023 Oct 30; Vol. 16, pp. 272-276. Date of Electronic Publication: 2023 Oct 30 (Print Publication: 2023). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: The University of Kansas Medical Center Country of Publication: United States NLM ID: 101581958 Publication Model: eCollection Cited Medium: Print ISSN: 1948-2035 (Print) Linking ISSN: 19482035 NLM ISO Abbreviation: Kans J Med Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Kansas City, KS : The University of Kansas Medical Center |
| مستخلص: | Introduction: Intra-articular antibiotics have been proposed as a treatment for septic arthritis to allow for high local concentrations without subjecting a patient to the toxicity/side effects of systemic therapy. However, there is concern for chondrotoxicity with intra-articular use of these solutions in high concentrations. The purpose of this systematic review was to evaluate the intra-articular use of antibiotics and antiseptic solutions, and to determine their association with chondrolysis following in vitro or in vivo administration. Methods: A systematic review was conducted following PRISMA guidelines through PubMed, Clinical Key, OVID, and Google Scholar. Studies in English were included if they evaluated for chondrotoxicity following antibiotic exposure. Results: The initial search resulted in 228 studies, with 36 studies meeting criteria. These 36 studies included manuscripts that studied 24 different agents. Overall, 7 of the 24 (29%) agents were non-chondrotoxic: minocycline, tetracycline, chloramphenicol, teicoplanin, pefloxacin, linezolid, polymyxin-bacitracin. Eight (33%) agents had inconsistent results: doxycycline, ceftriaxone, gentamicin, vancomycin, ciprofloxacin, ofloxacin, chlorhexidine, and povidone iodine. Chondrotoxicity was evident with 9 (38%) agents, all of which were also dose-dependent chondrotoxic based on reported estimated half maximal inhibitory concentrations (est. IC50): amikacin (est. IC50 = 0.31-2.74 mg/mL), neomycin (0.82), cefazolin (1.67-3.95), ceftazidime (3.16-3.59), ampicillin-sulbactam (8.64 - >25), penicillin (11.61), amoxicillin (14.01), imipenem (>25), and tobramycin (>25). Additionally, chondroprotective effects of doxycycline and minocycline were reported. Conclusions: This systematic review identified agents that may be used in the treatment of septic arthritis. Nine agents should be avoided due to their dose-dependent chondrotoxic effects. Further studies are needed to clarify the safety of these medications for human intra-articular use. (© 2023 The University of Kansas Medical Center.) |
| References: | Adv Dent Res. 1998 Nov;12(2):63-7. (PMID: 9972124) BMC Musculoskelet Disord. 2021 Apr 1;22(1):318. (PMID: 33794856) Rev Esp Cardiol (Engl Ed). 2021 Sep;74(9):790-799. (PMID: 34446261) J Arthroplasty. 2013 Jun;28(6):918-21. (PMID: 23528554) Bull Hosp Jt Dis. 2000;59(2):73-5. (PMID: 10983254) Equine Vet J. 2021 May;53(3):579-589. (PMID: 32544273) J Vet Pharmacol Ther. 2017 Dec;40(6):604-617. (PMID: 28317140) Arthroscopy. 2021 May;37(5):1683-1690. (PMID: 33359822) Biochem Pharmacol. 1998 Jan 1;55(1):93-100. (PMID: 9413935) J Orthop Trauma. 2018 Mar;32(3):148-153. (PMID: 29040232) Eur Arch Otorhinolaryngol. 2002 Nov;259(10):524-6. (PMID: 12434185) Dermatology. 2002;204 Suppl 1:86-91. (PMID: 12011528) Toxicol Appl Pharmacol. 2008 Jan 15;226(2):119-27. (PMID: 17961619) Knee Surg Sports Traumatol Arthrosc. 2016 Sep;24(9):2729-2735. (PMID: 25771788) Front Vet Sci. 2021 May 21;8:676774. (PMID: 34095281) Lancet Infect Dis. 2020 Mar;20(3):266-267. (PMID: 31862241) Int J Infect Dis. 2019 Apr;81:128-136. (PMID: 30772469) Am J Vet Res. 2006 Sep;67(9):1519-26. (PMID: 16948595) J Bone Joint Surg Am. 2019 Sep 18;101(18):1689-1697. (PMID: 31567806) J Orthop Res. 2005 Jan;23(1):127-33. (PMID: 15607884) Knee Surg Sports Traumatol Arthrosc. 2020 Apr;28(4):1005-1013. (PMID: 30656372) Knee Surg Sports Traumatol Arthrosc. 2016 Oct;24(10):3155-3162. (PMID: 26704806) Clin Orthop Relat Res. 2007 Sep;462:200-6. (PMID: 17572634) Toxicol Appl Pharmacol. 2014 Apr 15;276(2):121-8. (PMID: 24582689) Arch Orthop Trauma Surg. 2021 Mar;141(3):375-381. (PMID: 32236713) Am J Vet Res. 2007 Dec;68(12):1324-31. (PMID: 18052736) Arch Orthop Trauma Surg. 2022 Jun;142(6):1141-1146. (PMID: 34216258) J Orthop Res. 2020 Apr;38(4):726-730. (PMID: 31724230) Bone Joint J. 2016 Jan;98-B(1 Suppl A):31-6. (PMID: 26733638) Am J Vet Res. 1993 Oct;54(10):1784-9. (PMID: 8250408) Toxicol Appl Pharmacol. 2013 Feb 15;267(1):74-87. (PMID: 23274517) Acta Chir Orthop Traumatol Cech. 2019;86(4):276-280. (PMID: 31524589) J Infect Public Health. 2016 May-Jun;9(3):251-8. (PMID: 26603270) Orthop J Sports Med. 2019 Sep 25;7(9):2325967119871038. (PMID: 31598528) Knee. 2012 Oct;19(5):680-3. (PMID: 22297212) Orthop J Sports Med. 2022 Apr 4;10(4):23259671221087189. (PMID: 35400138) Vet Surg. 2021 Apr;50(3):650-658. (PMID: 33606293) J Pharmacol Exp Ther. 1994 Dec;271(3):1544-9. (PMID: 7996468) Knee Surg Sports Traumatol Arthrosc. 2019 Sep;27(9):3014-3021. (PMID: 30666370) J Bone Joint Surg Br. 1994 May;76(3):468-70. (PMID: 8175856) J Bone Joint Surg Am. 2020 Jan 2;102(1):76-84. (PMID: 31596810) Orthop Traumatol Surg Res. 2015 Feb;101(1):61-4. (PMID: 25623272) Physiol Rep. 2020 Sep;8(17):e14571. (PMID: 32918797) J Orthop Res. 2010 Apr;28(4):522-8. (PMID: 19813262) BMC Vet Res. 2013 Apr 10;9:68. (PMID: 23574696) Am J Vet Res. 2002 May;63(5):683-7. (PMID: 12013469) Clin Rheumatol. 2006 Sep;25(5):632-8. (PMID: 16365691) Adv Orthop. 2016;2016:8713037. (PMID: 27800188) Biochem Biophys Res Commun. 1997 Aug 8;237(1):107-10. (PMID: 9266839) Equine Vet J. 2020 Sep;52(5):715-724. (PMID: 31997397) J Bone Joint Surg Am. 2015 Apr 1;97(7):558-64. (PMID: 25834080) J Rheumatol. 2001 Feb;28(2):336-40. (PMID: 11246672) Acta Orthop Scand. 1987 Feb;58(1):14-9. (PMID: 3577735) Arthroscopy. 2006 Aug;22(8):902.e1-3. (PMID: 16904592) Clin Orthop Relat Res. 2019 Dec;477(12):2785-2797. (PMID: 31764352) Am J Vet Res. 2001 May;62(5):704-8. (PMID: 11341389) |
| فهرسة مساهمة: | Keywords: chondrotoxicity; intra-articular antibiotics; joint infection; septic arthritis |
| تواريخ الأحداث: | Date Created: 20231113 Latest Revision: 20231122 |
| رمز التحديث: | 20231123 |
| مُعرف محوري في PubMed: | PMC10635690 |
| DOI: | 10.17161/kjm.vol16.20357 |
| PMID: | 37954883 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1948-2035 |
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| DOI: | 10.17161/kjm.vol16.20357 |