دورية أكاديمية
Use of direct oral anticoagulants and low molecular weight heparin in venous thromboembolism associated with cancer: real-world evidence in Argentina.
| العنوان: | Use of direct oral anticoagulants and low molecular weight heparin in venous thromboembolism associated with cancer: real-world evidence in Argentina. |
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| المؤلفون: | Clavijo MM; Hematology and Oncology, Hospital Aleman, Buenos Aires, Argentina., Ruiz JI; Anderson Cancer Center, Department of Health Services Research, Division of Cancer Prevention and Population Sciences, Houston, TX, USA., Muñoz C; Hematology and Oncology, Hospital Aleman, Buenos Aires, Argentina., Vicente Reparaz M de Los A; Hematology and Oncology, Hospital Aleman, Buenos Aires, Argentina., Acuña MA; Hematology and Oncology, Hospital Aleman, Buenos Aires, Argentina., Casali CE; Hematology and Oncology, Hospital Aleman, Buenos Aires, Argentina., Aizpurua MF; Hematology and Oncology, Hospital Aleman, Buenos Aires, Argentina., Mahuad CV; Hematology and Oncology, Hospital Aleman, Buenos Aires, Argentina., Zerga ME; Hematology and Oncology, Hospital Aleman, Buenos Aires, Argentina.; Hematology, Angel A. Roffo Institute of Oncology, Buenos Aires, Argentina., Ventura A; Hematology and Oncology, Hospital Aleman, Buenos Aires, Argentina., Garate GM; Hematology and Oncology, Hospital Aleman, Buenos Aires, Argentina. |
| المصدر: | Expert review of hematology [Expert Rev Hematol] 2023 Jul-Dec; Vol. 16 (12), pp. 1143-1149. Date of Electronic Publication: 2023 Dec 18. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 101485942 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1747-4094 (Electronic) Linking ISSN: 17474094 NLM ISO Abbreviation: Expert Rev Hematol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Abingdon, Oxford : Taylor & Francis Original Publication: London : Expert Reviews |
| مواضيع طبية MeSH: | Venous Thromboembolism*/etiology , Venous Thromboembolism*/complications , Neoplasms*/complications , Neoplasms*/drug therapy, Adult ; Humans ; Heparin, Low-Molecular-Weight/adverse effects ; Retrospective Studies ; Argentina/epidemiology ; Anticoagulants/adverse effects ; Hemorrhage/etiology |
| مستخلص: | Background: Venous thromboembolism (VTE) and major bleeding (MB) are common in cancer patients. Reduced-doses of antithrombotics as secondary prophylaxis have limited data. This work aims to describe and to compare treatments and outcomes for cancer-associated VTE. Research Design and Methods: Retrospective study. Adults with cancer-associated VTE were included. After 3-6 months of full-doses of anticoagulants, three strategies were considered: A) lowering the doses; B) maintaining full-doses; C) stopping treatment. The strategy and medication used were shown in a descriptive analysis and the rate of bleeding and VTE-recurrence between those in a comparative analysis. Results: A total of 420 patients were included, 56.2% received DOACs, 43.8% enoxaparin. Strategy was defined in 257 patients: A (50.2%), B (46.3%), and C (3.5%). Forty-one (9.8%) had VTE-recurrence and 15 (3.6%) had MB or clinically relevant non-major bleeding (CRNMB).According to strategy, recurrent-VTE was 8.5% (A), 4.2% (B), and 11.1 (C) ( p = 0.22), MB or CRNMB was 0.8% (A), 1.7% (B), and 0% (C) ( p = 0.64). Conclusions: DOACs and strategy A were the most frequently used agent and strategy, respectively. There were no differences between medications or strategies used. The results must be interpreted with caution, and it is a retrospective single-center study, probably with information and selection bias. |
| فهرسة مساهمة: | Keywords: Thrombosis; anticoagulation; cancer; cancer associated thrombosis; deep vein thrombosis; direct oral anticoagulant; enoxaparin thromboembolism; pulmonary thromboembolism; venous thromboembolism |
| المشرفين على المادة: | 0 (Heparin, Low-Molecular-Weight) 0 (Anticoagulants) |
| تواريخ الأحداث: | Date Created: 20231113 Date Completed: 20231219 Latest Revision: 20240124 |
| رمز التحديث: | 20240125 |
| DOI: | 10.1080/17474086.2023.2281945 |
| PMID: | 37955142 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1747-4094 |
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| DOI: | 10.1080/17474086.2023.2281945 |