دورية أكاديمية
أعرض في EDS

Postoperative stereotactic radiosurgery for intracranial solitary fibrous tumors: systematic review and pooled quantitative analysis.

التفاصيل البيبلوغرافية
العنوان: Postoperative stereotactic radiosurgery for intracranial solitary fibrous tumors: systematic review and pooled quantitative analysis.
المؤلفون: Golub D; Department of Neurosurgery, Northwell Health, Manhasset, NY, USA. Dgolub1@northwell.edu., McBriar JD; Zucker School of Medicine, Hofstra University/Northwell Health, Hempstead, NY, USA., Donaldson H; Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Wong T; SUNY Downstate College of Medicine, Brooklyn, NY, USA., Unadkat P; Department of Neurosurgery, Northwell Health, Manhasset, NY, USA., White TG; Department of Neurosurgery, Northwell Health, Manhasset, NY, USA., Quach ET; Department of Neurosurgery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA., Haddock S; Department of Neurosurgery, NYU Grossman School of Medicine, New York, NY, USA., Chitti B; Department of Radiation Oncology, Northwell Health, Manhasset, NY, USA., Ziemba Y; Department of Pathology, Northwell Health, Manhasset, NY, USA., Goenka A; Department of Radiation Oncology, Northwell Health, Manhasset, NY, USA., Singer S; Department of Neurology, Northwell Health, New Hyde Park, NY, USA., Schulder M; Department of Neurosurgery, Northwell Health, Manhasset, NY, USA., Dehdashti AR; Department of Neurosurgery, Northwell Health, Manhasset, NY, USA.
المصدر: Journal of neuro-oncology [J Neurooncol] 2023 Nov; Vol. 165 (2), pp. 229-239. Date of Electronic Publication: 2023 Nov 13.
نوع المنشور: Systematic Review; Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 8309335 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7373 (Electronic) Linking ISSN: 0167594X NLM ISO Abbreviation: J Neurooncol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2005- : New York : Springer
Original Publication: Boston : M. Nijhoff, 1983-
مواضيع طبية MeSH: Radiosurgery*/methods , Severe Fever with Thrombocytopenia Syndrome* , Solitary Fibrous Tumors*/radiotherapy , Solitary Fibrous Tumors*/surgery, Humans ; Follow-Up Studies ; Retrospective Studies ; Treatment Outcome
مستخلص: Background: Intracranial solitary fibrous tumors (SFTs), formerly hemangiopericytomas (HPCs), are rare, aggressive dural-based mesenchymal tumors. While adjuvant radiation therapy has been suggested to improve local tumor control (LTC), especially after subtotal resection, the role of postoperative stereotactic radiosurgery (SRS) and the optimal SRS dosing strategy remain poorly defined.
Methods: PubMed, EMBASE, and Web of Science were systematically searched according to PRISMA guidelines for studies describing postoperative SRS for intracranial SFTs. The search strategy was defined in the authors' PROSPERO protocol (CRD42023454258).
Results: 15 studies were included describing 293 patients harboring 476 intracranial residual or recurrent SFTs treated with postoperative SRS. At a mean follow-up of 21-77 months, LTC rate after SRS was 46.4-93% with a mean margin SRS dose of 13.5-21.7 Gy, mean maximum dose of 27-39.6 Gy, and mean isodose at the 42.5-77% line. In pooled analysis of individual tumor outcomes, 18.7% of SFTs demonstrated a complete SRS response, 31.7% had a partial response, 18.9% remained stable (overall LTC rate of 69.3%), and 30.7% progressed. When studies were stratified by margin dose, a mean margin dose > 15 Gy showed an improvement in LTC rate (74.7% versus 65.7%).
Conclusions: SRS is a safe and effective treatment for intracranial SFTs. In the setting of measurable disease, our pooled data suggests a potential dose response of improving LTC with increasing SRS margin dose. Our improved understanding of the aggressive biology of SFTs and the tolerated adjuvant SRS parameters supports potentially earlier use of SRS in the postoperative treatment paradigm for intracranial SFTs.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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فهرسة مساهمة: Keywords: Gamma Knife; Hemangiopericytoma; Radiosurgery; Radiotherapy; Solitary fibrous Tumor
تواريخ الأحداث: Date Created: 20231113 Date Completed: 20231201 Latest Revision: 20231201
رمز التحديث: 20231201
DOI: 10.1007/s11060-023-04499-w
PMID: 37955760
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-7373
DOI:10.1007/s11060-023-04499-w