دورية أكاديمية
Opioid Analgesia Compared with Non-Opioid Analgesia After Operative Treatment for Pediatric Supracondylar Humeral Fractures: Results from a Prospective Multicenter Trial.
| العنوان: | Opioid Analgesia Compared with Non-Opioid Analgesia After Operative Treatment for Pediatric Supracondylar Humeral Fractures: Results from a Prospective Multicenter Trial. |
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| المؤلفون: | Belardo ZE; Division of Orthopaedics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Talwar D; Division of Orthopaedics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Blumberg TJ; Department of Orthopaedics and Sports Medicine, Seattle Children's Hospital, Seattle, Washington., Nelson SE; Department of Orthopaedics, University of Rochester Medical Center, Rochester, New York., Upasani VV; Department of Orthopaedics, Rady Children's Hospital, San Diego, California., Sankar WN; Division of Orthopaedics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Shah AS; Division of Orthopaedics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. |
| المصدر: | The Journal of bone and joint surgery. American volume [J Bone Joint Surg Am] 2023 Dec 06; Vol. 105 (23), pp. 1875-1885. Date of Electronic Publication: 2023 Oct 23. |
| نوع المنشور: | Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Journal of Bone and Joint Surgery Country of Publication: United States NLM ID: 0014030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-1386 (Electronic) Linking ISSN: 00219355 NLM ISO Abbreviation: J Bone Joint Surg Am Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Boston, MA : Journal of Bone and Joint Surgery |
| مواضيع طبية MeSH: | Analgesia* , Analgesics, Non-Narcotic*/therapeutic use , Humeral Fractures*/surgery, Child ; Female ; Humans ; Male ; Acetaminophen/therapeutic use ; Analgesics, Opioid/therapeutic use ; Ibuprofen/therapeutic use ; Oxycodone/therapeutic use ; Pain, Postoperative/drug therapy ; Pain, Postoperative/etiology ; Prospective Studies ; Child, Preschool |
| مستخلص: | Background: Minimal pain and opioid use after operative treatment for pediatric supracondylar humeral fractures have been previously described; however, opioid-prescribing practices in the United States remain variable. We hypothesized that children without an opioid prescription would report similar postoperative pain compared with children prescribed opioids following closed reduction and percutaneous pinning (CRPP) of supracondylar humeral fractures. Methods: Children who were 3 to 12 years of age and were undergoing CRPP for a closed supracondylar humeral fracture were prospectively enrolled in a multicenter, comparative study. Following a standardized dosing protocol, oxycodone, ibuprofen, and acetaminophen were prescribed at 2 hospitals (opioid cohort), and 2 other hospitals prescribed ibuprofen and acetaminophen alone (non-opioid cohort). The children's medication use and the daily pain that they experienced (scored on the Wong-Baker FACES Scale) were recorded at postoperative days 1 to 7, 10, 14, and 21, using validated text-message protocols. Based on an a priori power analysis, at least 64 evaluable subjects were recruited per cohort. Results: A total of 157 patients were evaluated (81 [52%] in the opioid cohort and 76 [48%] in the non-opioid cohort). The median age at the time of the surgical procedure was 6.2 years, and 50% of the subjects were male. The mean postoperative pain scores were low overall (<4 of 10), and there were no significant differences in pain ratings between cohorts at any time point. No patient demographic or injury characteristics were correlated with increased pain or medication use. Notably, of the 81 patients in the opioid cohort, 28 (35%) took no oxycodone and 40 (49%) took 1 to 3 total doses across the postoperative period. Patients rarely took opioids after postoperative day 2. A single patient in the non-opioid cohort (1 [1%] of 76) received a rescue prescription of opioids after presenting to the emergency department with postoperative cast discomfort. Conclusions: Non-opioid analgesia following CRPP for pediatric supracondylar humeral fractures was equally effective as opioid analgesia. When oxycodone was prescribed, 84% of children took 0 to 3 total doses, and opioid use fell precipitously after postoperative day 2. To improve opioid stewardship, providers and institutions can consider discontinuing the routine prescription of opioids following this procedure. Level of Evidence: Therapeutic Level II . See Instructions for Authors for a complete description of levels of evidence. Competing Interests: Disclosure: The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article ( http://links.lww.com/JBJS/H740 ). (Copyright © 2023 The Authors. Published by The Journal of Bone and Joint Surgery, Incorporated. All rights reserved.) |
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| المشرفين على المادة: | 362O9ITL9D (Acetaminophen) 0 (Analgesics, Non-Narcotic) 0 (Analgesics, Opioid) WK2XYI10QM (Ibuprofen) CD35PMG570 (Oxycodone) |
| تواريخ الأحداث: | Date Created: 20231113 Date Completed: 20240110 Latest Revision: 20240222 |
| رمز التحديث: | 20240222 |
| مُعرف محوري في PubMed: | PMC10695340 |
| DOI: | 10.2106/JBJS.23.00223 |
| PMID: | 37956188 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1535-1386 |
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| DOI: | 10.2106/JBJS.23.00223 |