دورية أكاديمية
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A glutamate-gated chloride channel as the mite-specific target-site of dicofol and other diphenylcarbinol acaricides.

التفاصيل البيبلوغرافية
العنوان: A glutamate-gated chloride channel as the mite-specific target-site of dicofol and other diphenylcarbinol acaricides.
المؤلفون: Vandenhole M; Department of Plants and Crops, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, Ghent, Belgium., Mermans C; Department of Plants and Crops, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, Ghent, Belgium., De Beer B; Department of Plants and Crops, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, Ghent, Belgium., Xue W; Department of Plants and Crops, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, Ghent, Belgium., Zhao Y; School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, 693 Xiongchu Blvd, Wuhan, China., Ozoe Y; Faculty of Life and Environmental Science, Shimane University, Matsue, Japan., Liu G; School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, 693 Xiongchu Blvd, Wuhan, China., Dermauw W; Department of Plants and Crops, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, Ghent, Belgium. wannes.dermauw@ilvo.vlaanderen.be.; Flanders Research Institute for Agriculture, Fisheries and Food (ILVO), Plant Sciences Unit, Burgemeester Van Gansberghelaan 96, Merelbeke, Belgium. wannes.dermauw@ilvo.vlaanderen.be., Van Leeuwen T; Department of Plants and Crops, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, Ghent, Belgium. thomas.vanleeuwen@ugent.be.
المصدر: Communications biology [Commun Biol] 2023 Nov 13; Vol. 6 (1), pp. 1160. Date of Electronic Publication: 2023 Nov 13.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London, United Kingdom : Nature Publishing Group UK, [2018]-
مواضيع طبية MeSH: Acaricides*/pharmacology, Dicofol ; Chloride Channels/genetics ; Mutation
مستخلص: Dicofol has been widely used to control phytophagous mites. Although dicofol is chemically related to DDT, its mode of action has remained elusive. Here, we mapped dicofol resistance in the spider mite Tetranychus urticae to two genomic regions. Each region harbored a glutamate-gated chloride channel (GluCl) gene that contained a mutation-G314D or G326E-known to confer resistance against the unrelated acaricide abamectin. Using electrophysiology assays we showed that dicofol and other diphenylcarbinol acaricides-bromopropylate and chlorobenzilate-induce persistent currents in Xenopus oocytes expressing wild-type T. urticae GluCl3 receptors and potentiate glutamate responses. In contrast, the G326E substitution abolished the agonistic activity of all three compounds. Assays with the wild-type Drosophila GluClα revealed that this receptor was unresponsive to dicofol. Homology modeling combined with ligand-docking confirmed the specificity of electrophysiology assays. Altogether, this work elucidates the mode of action of diphenylcarbinols as mite-specific agonists of GluCl.
(© 2023. The Author(s).)
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سلسلة جزيئية: figshare 10.6084/m9.figshare.2366818829
المشرفين على المادة: 0 (Acaricides)
W4WMM0WS91 (Dicofol)
0 (glutamate-gated chloride channels)
0 (Chloride Channels)
تواريخ الأحداث: Date Created: 20231113 Date Completed: 20231115 Latest Revision: 20231122
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10643420
DOI: 10.1038/s42003-023-05488-5
PMID: 37957415
قاعدة البيانات: MEDLINE
الوصف
تدمد:2399-3642
DOI:10.1038/s42003-023-05488-5