دورية أكاديمية
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Structural Analysis and Characterization of an Antiproliferative Lectin from Canavalia villosa Seeds.

التفاصيل البيبلوغرافية
العنوان: Structural Analysis and Characterization of an Antiproliferative Lectin from Canavalia villosa Seeds.
المؤلفون: Lossio CF; Laboratory of Biologically Active Molecules, Department of Biochemistry and Molecular Biology, Federal University of Ceara, Fortaleza 60440-970, Brazil., Osterne VJS; Laboratory of Biologically Active Molecules, Department of Biochemistry and Molecular Biology, Federal University of Ceara, Fortaleza 60440-970, Brazil.; Laboratory of Biochemistry and Glycobiology, Department of Biotechnology, Ghent University, 9000 Ghent, Belgium., Pinto-Junior VR; Laboratory of Biologically Active Molecules, Department of Biochemistry and Molecular Biology, Federal University of Ceara, Fortaleza 60440-970, Brazil.; Department of Physics, Federal University of Ceara, Fortaleza 60440-970, Brazil., Chen S; Laboratory of Biochemistry and Glycobiology, Department of Biotechnology, Ghent University, 9000 Ghent, Belgium., Oliveira MV; Laboratory of Biologically Active Molecules, Department of Biochemistry and Molecular Biology, Federal University of Ceara, Fortaleza 60440-970, Brazil., Verduijn J; Nano-Biotechnology Group, Department of Biotechnology, Ghent University, 9000 Ghent, Belgium., Verbeke I; Laboratory of Biochemistry and Glycobiology, Department of Biotechnology, Ghent University, 9000 Ghent, Belgium., Serna S; Glycotechnology Lab, Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramon 194, 20014 Donostia-San Sebastián, Spain., Reichardt NC; Glycotechnology Lab, Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramon 194, 20014 Donostia-San Sebastián, Spain.; Centro de Investigación Biomédica en Red (CIBER-BBN), Paseo de Miramon 194, 20014 Donostia-San Sebastián, Spain., Skirtach A; Nano-Biotechnology Group, Department of Biotechnology, Ghent University, 9000 Ghent, Belgium., Cavada BS; Laboratory of Biologically Active Molecules, Department of Biochemistry and Molecular Biology, Federal University of Ceara, Fortaleza 60440-970, Brazil., Van Damme EJM; Laboratory of Biochemistry and Glycobiology, Department of Biotechnology, Ghent University, 9000 Ghent, Belgium., Nascimento KS; Laboratory of Biologically Active Molecules, Department of Biochemistry and Molecular Biology, Federal University of Ceara, Fortaleza 60440-970, Brazil.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 04; Vol. 24 (21). Date of Electronic Publication: 2023 Nov 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Lectins*/pharmacology , Lectins*/analysis , Canavalia*/metabolism, Molecular Docking Simulation ; Plant Lectins/metabolism ; Seeds/metabolism ; Carbohydrates/analysis ; Polysaccharides/analysis
مستخلص: Cells use glycans to encode information that modulates processes ranging from cell-cell recognition to programmed cell death. This information is encoded within a glycocode, and its decoding is performed by carbohydrate-binding proteins. Among these, lectins stand out due to their specific and reversible interaction with carbohydrates. Changes in glycosylation patterns are observed in several pathologies, including cancer, where abnormal glycans are found on the surfaces of affected tissues. Given the importance of the bioprospection of promising biomolecules, the current work aimed to determine the structural properties and anticancer potential of the mannose-specific lectin from seeds of Canavalia villosa (Cvill). Experimental elucidation of the primary and 3D structures of the lectin, along with glycan array and molecular docking, facilitated the determination of its fine carbohydrate-binding specificity. These structural insights, coupled with the lectin's specificity, have been combined to explain the antiproliferative effect of Cvill against cancer cell lines. This effect is dependent on the carbohydrate-binding activity of Cvill and its uptake in the cells, with concomitant activation of autophagic and apoptotic pathways.
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معلومات مُعتمدة: not applicable National Council for Scientific and Technological Development; Not applicable Coordenação de Aperfeicoamento de Pessoal de Nível Superior; Not applicable Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico; CTQ 2017-90039-R Ministry of Science and Education (MINECO); RTC-2017-6126-1 Ministry of Science and Education (MINECO); PID2020-117552RB-I00 Spanish State Research Agency - AEI; MDM-2017-0720 Maria de Maeztu Units of Excellence Program; bmg21 Basque Government, Elkartek; 12T4622N Research Foundation - Flanders
فهرسة مساهمة: Keywords: Canavalia villosa; cancer; glycans; lectin
المشرفين على المادة: 0 (Lectins)
0 (Plant Lectins)
0 (Carbohydrates)
0 (Polysaccharides)
تواريخ الأحداث: Date Created: 20231114 Date Completed: 20231115 Latest Revision: 20231117
رمز التحديث: 20231117
مُعرف محوري في PubMed: PMC10649158
DOI: 10.3390/ijms242115966
PMID: 37958949
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms242115966