دورية أكاديمية
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Recent Advances in the Synthesis and Antioxidant Activity of Low Molecular Mass Organoselenium Molecules.

التفاصيل البيبلوغرافية
العنوان: Recent Advances in the Synthesis and Antioxidant Activity of Low Molecular Mass Organoselenium Molecules.
المؤلفون: Anghinoni JM; Laboratory of Clean Organic Synthesis (LASOL), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas 96010-900, RS, Brazil., Birmann PT; Neurobiotechnology Research Group (GPN), Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas 96010-900, RS, Brazil., da Rocha MJ; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas 96010-900, RS, Brazil., Gomes CS; Laboratory of Clean Organic Synthesis (LASOL), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas 96010-900, RS, Brazil., Davies MJ; Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Building 12.6, Blegdamsvej 3, 2200 Copenhagen, Denmark., Brüning CA; Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas 96010-900, RS, Brazil., Savegnago L; Neurobiotechnology Research Group (GPN), Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas 96010-900, RS, Brazil., Lenardão EJ; Laboratory of Clean Organic Synthesis (LASOL), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas 96010-900, RS, Brazil.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2023 Oct 30; Vol. 28 (21). Date of Electronic Publication: 2023 Oct 30.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Selenium*/pharmacology , Trace Elements* , Organoselenium Compounds*/pharmacology , Organoselenium Compounds*/chemistry, Antioxidants/chemistry ; Oxidative Stress ; Glutathione Peroxidase/metabolism ; Thioredoxin-Disulfide Reductase/metabolism
مستخلص: Selenium is an essential trace element in living organisms, and is present in selenoenzymes with antioxidant activity, like glutathione peroxidase (GPx) and thioredoxin reductase (TrxR). The search for small selenium-containing molecules that mimic selenoenzymes is a strong field of research in organic and medicinal chemistry. In this review, we review the synthesis and bioassays of new and known organoselenium compounds with antioxidant activity, covering the last five years. A detailed description of the synthetic procedures and the performed in vitro and in vivo bioassays is presented, highlighting the most active compounds in each series.
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معلومات مُعتمدة: 422645/2021-4 National Council for Scientific and Technological Development; 21/2551-0002094-6 Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; 001 Coordenação de Aperfeicoamento de Pessoal de Nível Superior; CT-INFRA Financiadora de Estudos e Projetos; NNF20SA0064214 Novo Nordisk Foundation
فهرسة مساهمة: Keywords: ABTS; DPPH; FRAP; GPx-like; SOD; antioxidant; catalase; lipid peroxidation; organoselenium
المشرفين على المادة: 0 (Antioxidants)
H6241UJ22B (Selenium)
EC 1.11.1.9 (Glutathione Peroxidase)
0 (Trace Elements)
0 (Organoselenium Compounds)
EC 1.8.1.9 (Thioredoxin-Disulfide Reductase)
تواريخ الأحداث: Date Created: 20231114 Date Completed: 20231115 Latest Revision: 20231117
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10649092
DOI: 10.3390/molecules28217349
PMID: 37959771
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules28217349