Arabidopsis AN3 and OLIGOCELLULA genes link telomere maintenance mechanisms with cell division and expansion control.
| العنوان: | Arabidopsis AN3 and OLIGOCELLULA genes link telomere maintenance mechanisms with cell division and expansion control. |
|---|---|
| المؤلفون: | Agabekian IA; Kazan Federal University: Kazanskij Privolzskij federal'nyj universitet., Abdulkina LR; Kazan Federal University: Kazanskij Privolzskij federal'nyj universitet., Lushnenko AY; Kazan Federal University: Kazanskij Privolzskij federal'nyj universitet., Young PG; Texas A&M University., Valeeva LR; Marshall University., Boskovic O; Marshall University., Lilly EG; Marshall University., Sharipova MR; Kazan Federal University: Kazanskij Privolzskij federal'nyj universitet., Shippen DE; Texas A&M University., Juenger TE; The University of Texas at Austin., Shakirov EV; Marshall University. |
| المصدر: | Research square [Res Sq] 2023 Oct 28. Date of Electronic Publication: 2023 Oct 28. |
| نوع المنشور: | Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE |
| مستخلص: | Telomeres are conserved chromosomal structures necessary for continued cell division and proliferation. In addition to the classical telomerase pathway, multiple other genes including those involved in ribosome metabolism and chromatin modification contribute to telomere length maintenance. We previously reported that Arabidopsis thaliana ribosome biogenesis genes OLI2/NOP2A, OLI5/RPL5A and OLI7/RPL5B have critical roles in telomere length regulation. These three OLIGOCELLULA genes were also shown to function in cell proliferation and expansion control and to genetically interact with the transcriptional co-activator ANGUSTIFOLIA3 (AN3) . Here we show that AN3 -deficient plants progressively lose telomeric DNA in early homozygous mutant generations, but ultimately establish a new shorter telomere length setpoint by the fifth mutant generation with a telomere length similar to oli2/nop2a - deficient plants. Analysis of double an3 oli2 mutants indicates that the two genes are epistatic for telomere length control. Telomere shortening in an3 and oli mutants is not caused by telomerase inhibition; wild type levels of telomerase activity are detected in all analyzed mutants in vitro . Late generations of an3 and oli mutants are prone to stem cell damage in the root apical meristem, implying that genes regulating telomere length may have conserved functional roles in stem cell maintenance mechanisms. Multiple instances of anaphase fusions in late generations of oli5 and oli7 mutants were observed, highlighting an unexpected effect of ribosome biogenesis factors on chromosome integrity. Overall, our data implicate AN3 transcription coactivator and OLIGOCELLULA proteins in the establishment of telomere length set point in plants and further suggest that multiple regulators with pleiotropic functions can connect telomere biology with cell proliferation and cell expansion pathways. |
| التعليقات: | Update in: Plant Mol Biol. 2024 May 30;114(3):65. doi: 10.1007/s11103-024-01457-6. (PMID: 38816532) |
| References: | Chromosoma. 2020 Dec;129(3-4):181-200. (PMID: 32671520) Development. 2008 Apr;135(7):1315-24. (PMID: 18305008) Plant Cell. 2020 Dec;32(12):3812-3824. (PMID: 32989172) Plant Cell. 2014 Jan;26(1):210-29. (PMID: 24443518) Front Cell Dev Biol. 2021 Apr 01;9:668171. (PMID: 33869233) Plant Cell. 2022 Jul 4;34(7):2492-2504. (PMID: 35511166) Proc Jpn Acad Ser B Phys Biol Sci. 2014;90(4):119-29. (PMID: 24727936) Genes Dev. 1996 Jun 1;10(11):1310-26. (PMID: 8647430) RNA. 2021 Dec;27(12):1441-1458. (PMID: 34556550) Plant J. 2009 Aug;59(3):499-508. (PMID: 19392710) Am J Hum Genet. 2020 Mar 5;106(3):389-404. (PMID: 32109421) Nat Rev Mol Cell Biol. 2004 Apr;5(4):323-9. (PMID: 15071557) Front Plant Sci. 2019 Apr 30;10:520. (PMID: 31114598) Dev Cell. 2016 Dec 19;39(6):638-652. (PMID: 27997823) Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24542-24550. (PMID: 31754031) Plant J. 2011 Nov;68(4):657-69. (PMID: 21781195) PLoS One. 2015 Jul 21;10(7):e0133321. (PMID: 26196125) Front Genet. 2016 Jan 05;6:349. (PMID: 26779251) J Plant Res. 2006 Jan;119(1):37-42. (PMID: 16284709) Oncogene. 2003 Nov 6;22(50):8156-67. (PMID: 14603256) Plant Physiol. 2009 Oct;151(2):655-68. (PMID: 19648231) Nucleic Acids Res. 2003 May 1;31(9):2424-33. (PMID: 12711688) Curr Opin Biotechnol. 2023 Feb;79:102848. (PMID: 36463838) Cancers (Basel). 2022 Feb 05;14(3):. (PMID: 35159075) Nucleic Acids Res. 2014 Feb;42(3):e21. (PMID: 24366880) Bionanoscience. 2016 Dec;6(4):325-328. (PMID: 28133587) Hum Mol Genet. 1997 Sep;6(9):1559-64. (PMID: 9285794) Plant Cell Rep. 2020 Dec;39(12):1669-1685. (PMID: 32959123) Science. 2001 Mar 2;291(5509):1797-800. (PMID: 11230697) Plant Cell. 2013 Apr;25(4):1343-54. (PMID: 23572541) Front Plant Sci. 2016 Jun 28;7:851. (PMID: 27446102) Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8658-63. (PMID: 15161972) Cell Rep. 2015 May 12;11(6):977-989. (PMID: 25937286) Plant Cell. 2021 May 31;33(4):1118-1134. (PMID: 33580702) J Cell Sci. 2016 Apr 15;129(8):1566-79. (PMID: 26906424) Semin Cancer Biol. 2016 Jun;37-38:36-50. (PMID: 26721423) Cell. 2013 Mar 28;153(1):193-205. (PMID: 23540698) Mol Cancer Res. 2013 Oct;11(10):1141-58. (PMID: 23928056) Nat Commun. 2019 Dec 2;10(1):5479. (PMID: 31792215) Development. 2008 Apr;135(7):1325-34. (PMID: 18305007) Mol Cell. 2009 Oct 23;36(2):207-18. (PMID: 19854131) Cancer Res. 1988 Mar 1;48(5):1244-51. (PMID: 3422591) Bionanoscience. 2016 Dec;6(4):407-410. (PMID: 28191385) Oncotarget. 2017 Feb 28;8(9):14462-14478. (PMID: 28147343) Genetics. 2020 Aug;215(4):989-1002. (PMID: 32532801) Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14813-8. (PMID: 10611295) Plant Physiol. 2023 May 31;192(2):1115-1131. (PMID: 36943300) Oncogene. 2018 May;37(18):2351-2366. (PMID: 29429989) Biochem Cell Biol. 2023 Oct 1;101(5):394-409. (PMID: 36989538) Front Plant Sci. 2020 Aug 12;11:1160. (PMID: 32903463) J Biol Chem. 2019 Oct 4;294(40):14803-14813. (PMID: 31434740) Plant Cell. 2018 Feb;30(2):347-359. (PMID: 29352064) Nat Genet. 2013 Apr;45(4):422-7, 427e1-2. (PMID: 23535734) EMBO J. 2004 Jun 2;23(11):2304-13. (PMID: 15141167) Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19815-20. (PMID: 19064932) Mol Oncol. 2022 Sep;16(18):3380-3396. (PMID: 35920280) Front Plant Sci. 2011 Jul 01;2:24. (PMID: 22639585) Plant Cell. 2010 Sep;22(9):3020-33. (PMID: 20876831) Plant Cell Rep. 2018 Mar;37(3):501-513. (PMID: 29392401) EMBO J. 2015 Jul 14;34(14):1942-58. (PMID: 26041456) Plant Cell Physiol. 2020 Jun 1;61(6):1181-1190. (PMID: 32321167) Bioengineered. 2022 Apr;13(4):8076-8086. (PMID: 35293275) |
| معلومات مُعتمدة: | R01 GM065383 United States GM NIGMS NIH HHS; R01 GM127402 United States GM NIGMS NIH HHS |
| فهرسة مساهمة: | Keywords: Arabidopsis thaliana; NOP2; ribosomal proteins; telomerase; telomere dynamics; tert |
| تواريخ الأحداث: | Date Created: 20231114 Latest Revision: 20240610 |
| رمز التحديث: | 20240610 |
| مُعرف محوري في PubMed: | PMC10635316 |
| DOI: | 10.21203/rs.3.rs-3438810/v1 |
| PMID: | 37961382 |
| قاعدة البيانات: | MEDLINE |
| DOI: | 10.21203/rs.3.rs-3438810/v1 |
|---|