دورية أكاديمية
أعرض في EDS

Electrocardiograms Do Not Detect Myocardial Ischemia in Patients With Williams Syndrome and Nonsyndromic Elastin Arteriopathy With Coronary Artery Stenosis.

التفاصيل البيبلوغرافية
العنوان: Electrocardiograms Do Not Detect Myocardial Ischemia in Patients With Williams Syndrome and Nonsyndromic Elastin Arteriopathy With Coronary Artery Stenosis.
المؤلفون: Algaze C; Division of Pediatric Cardiology, Lucile Packard Children's Hospital, Stanford University, Palo Alto, California. Electronic address: calgaze@stanford.edu., Chubb H; Division of Pediatric Cardiology, Lucile Packard Children's Hospital, Stanford University, Palo Alto, California., Deitch AM; Division of Pediatric Cardiology, Lucile Packard Children's Hospital, Stanford University, Palo Alto, California., Collins T 2nd; Division of Cardiology, Department of Pediatrics, University of Kentucky College of Medicine, Lexington, Kentucky.
المصدر: The American journal of cardiology [Am J Cardiol] 2024 Mar 15; Vol. 215, pp. 50-55. Date of Electronic Publication: 2023 Nov 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Excerpta Medica Country of Publication: United States NLM ID: 0207277 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1913 (Electronic) Linking ISSN: 00029149 NLM ISO Abbreviation: Am J Cardiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Excerpta Medica
مواضيع طبية MeSH: Williams Syndrome*/complications , Williams Syndrome*/diagnosis , Aortic Stenosis, Supravalvular*/complications , Aortic Stenosis, Supravalvular*/diagnosis , Coronary Artery Disease* , Myocardial Ischemia*/diagnosis , Coronary Stenosis*/diagnosis , Vascular Diseases*, Humans ; Male ; Child ; Infant ; Female ; Retrospective Studies ; Elastin ; Electrocardiography
مستخلص: Coronary artery stenosis (CAS) may affect up to 27% of patients with Williams syndrome (WS), which may lead to myocardial ischemia. Patients with WS face a 25- to 100-fold greater risk of sudden cardiac death, frequently linked to anesthesia. Assessing CAS requires either imaging while under general anesthesia or intraoperative assessment, with the latter considered the gold standard. Our study aimed to identify electrocardiogram (ECG) markers of myocardial ischemia in patients with WS or nonsyndromic elastin arteriopathy and documented CAS. We retrospectively reviewed patients with WS/elastin arteriopathy who underwent supravalvar aortic stenosis surgery and CAS assessment from January 1, 2006 to April 30, 2021. A pediatric electrophysiologist, not aware of the patients' CAS status, reviewed their preoperative ECGs for markers of ischemia. We assessed associations of study parameters using Wilcoxon rank-sum and Fisher's exact tests. Of 34 patients, 62% were male, with a median age of 20 months (interquartile range: 8 to 34). CAS was present in 62% (21 of 34), 76% of whom (16 of 21) were male. There were no ECG indicators of myocardial ischemia in patients with CAS. In conclusion, CAS was present in >1/2 the children with WS/elastin arteriopathy who underwent repair of supravalvar aortic stenosis. CAS in WS/nonsyndromic elastin arteriopathy does not appear to exhibit typical ECG-detectable myocardial ischemia. ECGs are not a useful screening tool for CAS in WS/elastin arteriopathy. Given the high anesthesia-related cardiac arrest risk, other noninvasive indicators of CAS are needed.
Competing Interests: Declaration of competing interest The authors have no competing interests to declare.
(Published by Elsevier Inc.)
فهرسة مساهمة: Keywords: Williams syndrome; coronary artery stenosis; electrocardiogram
المشرفين على المادة: 9007-58-3 (Elastin)
تواريخ الأحداث: Date Created: 20231114 Date Completed: 20240304 Latest Revision: 20240305
رمز التحديث: 20240306
DOI: 10.1016/j.amjcard.2023.11.020
PMID: 37963512
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-1913
DOI:10.1016/j.amjcard.2023.11.020