دورية أكاديمية
أعرض في EDS

Integrated genomic network analysis revealed potential of a druggable target for hemorrhoid treatment.

التفاصيل البيبلوغرافية
العنوان: Integrated genomic network analysis revealed potential of a druggable target for hemorrhoid treatment.
المؤلفون: Adikusuma W; Departement of Pharmacy, University of Muhammadiyah Mataram, Mataram, Indonesia.; Research Center for Vaccine and Drugs, National Research and Innovation Agency (BRIN), South Tangerang, Indonesia., Firdayani F; Research Center for Vaccine and Drugs, National Research and Innovation Agency (BRIN), South Tangerang, Indonesia., Irham LM; Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia., Darmawi D; Department of Histology, Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia.; Graduate School in Biomedical Sciences, Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia., Hamidy MY; Department of Pharmacology, Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia., Nopitasari BL; Departement of Pharmacy, University of Muhammadiyah Mataram, Mataram, Indonesia., Soraya S; Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia., Azizah N; Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia.
المصدر: Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society [Saudi Pharm J] 2023 Dec; Vol. 31 (12), pp. 101831. Date of Electronic Publication: 2023 Oct 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Saudi Pharmaceutical Society Country of Publication: Saudi Arabia NLM ID: 9705695 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1319-0164 (Print) Linking ISSN: 13190164 NLM ISO Abbreviation: Saudi Pharm J Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: Riyadh : Saudi Pharmaceutical Society
Original Publication: Riyadh, Kingdom of Saudi Arabia : The Society,
مستخلص: Hemorrhoids are a prevalent medical condition that necessitates effective treatment options. The current options for treatment consist of oral medications, topical applications, or surgery, yet a scarcity of highly effective drugs still exists. Genetic markers provide promising avenues for investigating the treatment of hemorrhoids, as they may reveal intricate biological mechanisms and targeted drug therapies, ultimately enhancing more precise treatment tailored to the patient. This study aims to identify new drug candidates for treating hemorrhoids through a meticulous bioinformatics approach and integrated with genomic network analysis. After extracting 21 druggable target genes using DrugBank from 293 genes connected to hemorrhoids, 87 possible drugs were selected. Three of these drugs (ketamine, methylene blue, and fulvestrant) hold potential in addressing issues associated with hemorrhoids and have been supported by clinical or preclinical studies. Eighty-four compounds present new therapeutic possibilities for managing hemorrhoids. We highlight that our findings indicate that NOX1 and NOS3 genes are promising biomarkers, with NOS3 gaining significance owing to its robust systemic functional annotations. Sapropterin, an existing drug, is closely associated with NOS3 , providing a clear target for biomarker-driven interventions. This study illustrates the potential of combining genomic network analysis with bioinformatics to repurpose drugs for treating hemorrhoids. Subsequent research will explore the mechanisms for utilizing NOS3 targeting in the treatment of hemorrhoids.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2023 The Author(s).)
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فهرسة مساهمة: Keywords: Drug repositioning; Genomic network analysis; Hemorrhoids; Sapropterin
تواريخ الأحداث: Date Created: 20231115 Latest Revision: 20240212
رمز التحديث: 20240213
مُعرف محوري في PubMed: PMC10641558
DOI: 10.1016/j.jsps.2023.101831
PMID: 37965490
قاعدة البيانات: MEDLINE
الوصف
تدمد:1319-0164
DOI:10.1016/j.jsps.2023.101831