دورية أكاديمية
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An Offset Patterned Cross-β Structure in Assemblies of C 3 -Symmetric Peptide Amphiphiles.

التفاصيل البيبلوغرافية
العنوان: An Offset Patterned Cross-β Structure in Assemblies of C 3 -Symmetric Peptide Amphiphiles.
المؤلفون: Zagorodko O; Polymer Therapeutics Lab, Centro de Investigación Príncipe Felipe, C/d'Eduardo Primo Yúfera, 3, 46012, Valencia, Spain.; Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, P. O. Box 513, 5600 MB, Eindhoven, The Netherlands., Melnyk T; Polymer Therapeutics Lab, Centro de Investigación Príncipe Felipe, C/d'Eduardo Primo Yúfera, 3, 46012, Valencia, Spain.; Centro de Investigación, Biomédica en Red en Oncología (CIBERONC), Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain., Nebot VJ; Polymer Therapeutics Lab, Centro de Investigación Príncipe Felipe, C/d'Eduardo Primo Yúfera, 3, 46012, Valencia, Spain.; Curapath, Av. Benjamín Franklin, 19, 46980, Paterna, Valencia, Spain., Dankers PYW; Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, P. O. Box 513, 5600 MB, Eindhoven, The Netherlands., Vicent MJ; Polymer Therapeutics Lab, Centro de Investigación Príncipe Felipe, C/d'Eduardo Primo Yúfera, 3, 46012, Valencia, Spain.; Centro de Investigación, Biomédica en Red en Oncología (CIBERONC), Av. Monforte de Lemos, 3-5, 28029, Madrid, Spain.
المصدر: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Feb 01; Vol. 30 (7), pp. e202303194. Date of Electronic Publication: 2023 Dec 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9513783 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3765 (Electronic) Linking ISSN: 09476539 NLM ISO Abbreviation: Chemistry Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim, Germany : Wiley-VCH
مواضيع طبية MeSH: Peptides*/chemistry , Amyloid*/chemistry, Protein Structure, Secondary ; Protein Conformation, beta-Strand ; Phenylalanine
مستخلص: Developing peptide-based materials with controlled morphology is a critical theme of soft matter research. Herein, we report the formation of a novel, patterned cross-β structure formed by self-assembled C 3 -symmetric peptide amphiphiles based on diphenylalanine and benzene-1,3,5-tricarboxamide (BTA). The cross-β motif is an abundant structural element in amyloid fibrils and aggregates of fibril-forming peptides, including diphenylalanine. The incorporation of topological constraints on one edge of the diphenylalanine fragment limits the number of β-strands in β-sheets and leads to the creation of an unconventional offset-patterned cross-β structure consisting of short 3×2 parallel β-sheets stabilized by phenylalanine zippers. In the reported assembly, two patterned cross-β structures bind parallel arrays of BTA stacks in a superstructure within a single-molecule-thick nanoribbon. In addition to a threefold network of hydrogen bonds in the BTA stack, each molecule becomes simultaneously bound by hydrogen bonds from three β-sheets and four phenylalanine zippers. The diffuse layer of alkyl chains with terminal polar groups prevents the nanoribbons from merging and stabilizes cross-β-structure in water. Our results provide a simple approach to the incorporation of novel patterned cross-β motifs into supramolecular superstructures and shed light on the general mechanism of β-sheet formation in C 3 -symmetric peptide amphiphiles.
(© 2023 Wiley-VCH GmbH.)
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معلومات مُعتمدة: PID2019-108806RB-I00 Ministerio de Economía y Competitividad; ERC-CoG-2014-648831 MyNano HORIZON EUROPE European Research Council; Gravity Program 024.005.020 Ministerie van Onderwijs, Cultuur en Wetenschap; EyeSciTe Chemelot InSciTe; PRDVA17201MELN Fundación Científica Asociación Española Contra el Cáncer; PO FEDER of Comunitat Valenciana, 2014 - 2020 Generalitat Valenciana
فهرسة مساهمة: Keywords: benzene-1,3,5-tricarboxamide; cross-beta; peptide amphiphiles; self-assembly; supramolecular polymers
المشرفين على المادة: 0 (Peptides)
0 (Amyloid)
47E5O17Y3R (Phenylalanine)
تواريخ الأحداث: Date Created: 20231115 Date Completed: 20240205 Latest Revision: 20240205
رمز التحديث: 20240205
DOI: 10.1002/chem.202303194
PMID: 37967312
قاعدة البيانات: MEDLINE
الوصف
تدمد:1521-3765
DOI:10.1002/chem.202303194