دورية أكاديمية
أعرض في EDS

Bovine neutrophils kill the sexually-transmitted parasite Tritrichomonas foetus using trogocytosis.

التفاصيل البيبلوغرافية
العنوان: Bovine neutrophils kill the sexually-transmitted parasite Tritrichomonas foetus using trogocytosis.
المؤلفون: Najera J; Department of Biological Sciences, California State Polytechnic University Pomona, Pomona, CA, 91768, USA., Berry MM; Department of Biological Sciences, California State Polytechnic University Pomona, Pomona, CA, 91768, USA., Ramirez AD; Department of Biological Sciences, California State Polytechnic University Pomona, Pomona, CA, 91768, USA., Reyes BR; Department of Biological Sciences, California State Polytechnic University Pomona, Pomona, CA, 91768, USA., Angel A; Department of Biological Sciences, California State Polytechnic University Pomona, Pomona, CA, 91768, USA., Jellyman JK; Department of Biological Sciences, California State Polytechnic University Pomona, Pomona, CA, 91768, USA., Mercer F; Department of Biological Sciences, California State Polytechnic University Pomona, Pomona, CA, 91768, USA. fkmercer@cpp.edu.
المصدر: Veterinary research communications [Vet Res Commun] 2024 Apr; Vol. 48 (2), pp. 865-875. Date of Electronic Publication: 2023 Nov 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Switzerland NLM ID: 8100520 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7446 (Electronic) Linking ISSN: 01657380 NLM ISO Abbreviation: Vet Res Commun Subsets: MEDLINE
أسماء مطبوعة: Publication: [Cham] : Springer
Original Publication: [Amsterdam] : Elsevier, 1980-
مواضيع طبية MeSH: Tritrichomonas foetus* , Parasites* , Cattle Diseases*/parasitology , Protozoan Infections, Animal*/parasitology , Protozoan Infections, Animal*/prevention & control, Cattle ; Animals ; Neutrophils ; Trogocytosis
مستخلص: The protozoan parasite Tritrichomonas foetus (T. foetus) is the causative organism of bovine trichomonosis (also referred to as trichomoniasis), a sexually-transmitted infection that reduces fertility in cattle. Efforts to control trichomonosis on cattle farms are hindered by the discouragement of antibiotic use in agriculture, and the incomplete, short-lived protection conferred by the current vaccines. A more complete mechanistic understanding of what effective immunity to T. foetus entails could enable the development of more robust infection control strategies. While neutrophils, the primary responders to infection, are present in infected tissues and have been shown to kill the parasite in vitro, the mechanism they use for parasite killing has not been established. Here, we show that primary bovine neutrophils isolated from peripheral blood rapidly kill T. foetus in vitro in a dose-dependent manner, and that optimal parasite killing is reduced by inhibitors of trogocytosis. We also use imaging to show that bovine neutrophils surround T. foetus and trogocytose its membrane. These findings are consistent with killing via trogocytosis, a recently described novel neutrophil antimicrobial mechanism.
(© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
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معلومات مُعتمدة: SC3 GM135046 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: Tritrichomonas foetus; Neutrophil; Trichomoniasis; Trichomonosis; Trogocytosis
تواريخ الأحداث: Date Created: 20231115 Date Completed: 20240408 Latest Revision: 20240414
رمز التحديث: 20240414
مُعرف محوري في PubMed: PMC10998815
DOI: 10.1007/s11259-023-10260-5
PMID: 37968413
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-7446
DOI:10.1007/s11259-023-10260-5