دورية أكاديمية
Neoadjuvant immunotherapy combined with chemotherapy in the treatment of stage III lung squamous cell carcinoma: a retrospective cohort study.
| العنوان: | Neoadjuvant immunotherapy combined with chemotherapy in the treatment of stage III lung squamous cell carcinoma: a retrospective cohort study. |
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| المؤلفون: | Guo J; Department of Thoracic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, China., Lin SD; Department of Thoracic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, China., Minervini F; Department of Thoracic Surgery, Cantonal Hospital Lucerne, Lucerne, Switzerland., Geraci TC; Division of Thoracic Surgery, Department of Cardiothoracic Surgery, New York University Langone Health, New York, NY, USA., Kim JJ; Department of Thoracic and Cardiovascular Surgery, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Seoul, Republic of Korea., Tong CY; Department of Thoracic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, China., Li XJ; Department of Thoracic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, China., Cao C; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Ningbo University, Ningbo, China. |
| المصدر: | Journal of thoracic disease [J Thorac Dis] 2023 Oct 31; Vol. 15 (10), pp. 5658-5668. Date of Electronic Publication: 2023 Sep 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: AME Publishing Company Country of Publication: China NLM ID: 101533916 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2072-1439 (Print) Linking ISSN: 20721439 NLM ISO Abbreviation: J Thorac Dis Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: Hong Kong : AME Publishing Company Original Publication: Hong Kong : Pioneer Bioscience Pub. Co. |
| مستخلص: | Background: Neoadjuvant immunochemotherapy has been proven to be a successful therapeutic strategy for patients with locally advanced non-small cell lung cancer (NSCLC). Nevertheless, there is a paucity of information regarding surgical feasibility and safety as well as tumor response. The present study aimed to investigate the therapeutic and surgical outcomes for patients with stage III lung squamous cell carcinoma (LSCC). Methods: Patients with stage III potentially resectable LSCC treated with neoadjuvant immunochemotherapy at The First Affiliated Hospital of Ningbo University between March 2020 and June 2022 were retrospectively included. Oncologic outcomes and intraoperative and postoperative variables were assessed. Results: A total of 17 locally advanced LSCC patients were included in the study. Patients in stages IIIA and IIIB were represented by 10 (58.8%) and 7 (41.2%) cases, respectively. A minimally invasive procedure was successfully completed in 12 out of 17 cases (70.6%). A total of 10 patients (58.8%) had standard lobectomies performed, 1 (5.9%) had a bilobectomy, 3 (17.6%) had pneumonectomies, and 1 (5.9%) had a wedge resection. A total of 7 patients (41.2%) experienced postoperative complications, and there were no 30- or 90-day mortalities. The 2-year disease-free survival (DFS) and overall survival (OS) rates were 76.6% and 82.5%, respectively. The rate of major pathological response (MPR) was 70.6%. Conclusions: Lung resection after immunochemotherapy for potentially resectable stage III LSCC is feasible and safe. This treatment strategy results in a significant pathologic response and promising rates of OS at 2 years. Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-23-1175/coif). The authors have no conflicts of interest to declare. (2023 Journal of Thoracic Disease. All rights reserved.) |
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| فهرسة مساهمة: | Keywords: Non-small cell lung cancer (NSCLC); immunochemotherapy; lung squamous cell carcinoma (LSCC); neoadjuvant therapy; survival |
| تواريخ الأحداث: | Date Created: 20231116 Latest Revision: 20231117 |
| رمز التحديث: | 20231117 |
| مُعرف محوري في PubMed: | PMC10636463 |
| DOI: | 10.21037/jtd-23-1175 |
| PMID: | 37969291 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2072-1439 |
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| DOI: | 10.21037/jtd-23-1175 |