دورية أكاديمية
A new acyl derivative of sulfadimethoxine inhibits phagocyte oxidative burst and ameliorates inflammation in a mice model of zymosan-induced generalised inflammation.
| العنوان: | A new acyl derivative of sulfadimethoxine inhibits phagocyte oxidative burst and ameliorates inflammation in a mice model of zymosan-induced generalised inflammation. |
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| المؤلفون: | Baig TA; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Haniffa HM; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.; Department of Chemical Sciences, Faculty of Applied Sciences, South Eastern University, Sammanthurai, 32200, Sri Lanka., Siddiqui H; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Shah SF; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Jabeen A; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan. almas@iccs.edu. |
| المصدر: | Inflammopharmacology [Inflammopharmacology] 2023 Dec; Vol. 31 (6), pp. 3303-3316. Date of Electronic Publication: 2023 Nov 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Birkhäuser Country of Publication: Switzerland NLM ID: 9112626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-5608 (Electronic) Linking ISSN: 09254692 NLM ISO Abbreviation: Inflammopharmacology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Basel ; Boston : Birkhäuser Original Publication: Dordrecht, The Netherlands ; Norwell, MA, USA : Kluwer Academic Publishers, c1991- |
| مواضيع طبية MeSH: | Sulfadimethoxine*/adverse effects , Sulfadimethoxine*/metabolism , Respiratory Burst*, Animals ; Mice ; Zymosan/pharmacology ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/metabolism ; Anti-Inflammatory Agents/therapeutic use ; Cytokines/metabolism ; NF-kappa B/metabolism ; Phagocytes/metabolism ; Disease Models, Animal ; Nitric Oxide/metabolism ; Lipopolysaccharides/pharmacology |
| مستخلص: | Chronic inflammation and oxidative stress play a pivotal role in the pathophysiology of most challenging illnesses, including cancer, Alzheimer's, cardiovascular and autoimmune diseases. The present study aimed to investigate the anti-inflammatory potential of a new sulfadimethoxine derivative N-(4-(N-(2,6-dimethoxypyrimidin-4-yl) sulfamoyl) phenyl) dodecanamide (MHH-II-32). The compound was characterised by applying 1 H-, 13 C-NMR, EI-MS and HRFAB-MS spectroscopic techniques. The compound inhibited zymosan-induced oxidative bursts from whole blood phagocytes and isolated polymorphonuclear cells with an IC (© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.) |
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| معلومات مُعتمدة: | NRPU-8263 Higher Education Commision, Pakistan |
| فهرسة مساهمة: | Keywords: Anti-inflammatory; Cytokines; Nitric oxide; Oxidative burst; Sulfadimethoxine; Zymosan |
| المشرفين على المادة: | 9010-72-4 (Zymosan) 30CPC5LDEX (Sulfadimethoxine) 0 (Anti-Inflammatory Agents) 0 (Cytokines) 0 (NF-kappa B) 31C4KY9ESH (Nitric Oxide) 0 (Lipopolysaccharides) |
| تواريخ الأحداث: | Date Created: 20231116 Date Completed: 20231204 Latest Revision: 20231204 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s10787-023-01372-0 |
| PMID: | 37971604 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1568-5608 |
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| DOI: | 10.1007/s10787-023-01372-0 |