دورية أكاديمية
Mortality surrogates in combined pulmonary fibrosis and emphysema.
| العنوان: | Mortality surrogates in combined pulmonary fibrosis and emphysema. |
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| المؤلفون: | Zhao A; Satsuma Lab, Centre for Medical Image Computing, UCL, London, UK.; Centre for Medical Image Computing, UCL, London, UK., Gudmundsson E; Satsuma Lab, Centre for Medical Image Computing, UCL, London, UK.; Centre for Medical Image Computing, UCL, London, UK., Mogulkoc N; Department of Respiratory Medicine, Ege University Hospital, Izmir, Turkey., van Moorsel C; Interstitial Lung Diseases Center of Excellence, Department of Pulmonology, St Antonius Hospital, Nieuwegein, The Netherlands., Corte TJ; Department of Respiratory Medicine, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia., Vasudev P; Satsuma Lab, Centre for Medical Image Computing, UCL, London, UK.; Centre for Medical Image Computing, UCL, London, UK., Romei C; Department of Radiology, Pisa University Hospital, Pisa, Italy., Chapman R; Interstitial Lung Disease Service, Department of Respiratory Medicine, University College London Hospitals NHS Foundation Trust, London, UK., Wallis TJM; NIHR Southampton Biomedical Research Centre and Clinical and Experimental Sciences, University of Southampton, Southampton, UK., Denneny E; Interstitial Lung Disease Service, Department of Respiratory Medicine, University College London Hospitals NHS Foundation Trust, London, UK., Goos T; BREATHE, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.; Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium., Savas R; Department of Radiology, Ege University Hospital, Izmir, Turkey., Ahmed A; Department of Radiology, University College London Hospitals NHS Foundation Trust, London, UK., Brereton CJ; NIHR Southampton Biomedical Research Centre and Clinical and Experimental Sciences, University of Southampton, Southampton, UK., van Es HW; Interstitial Lung Diseases Center of Excellence, Department of Pulmonology, St Antonius Hospital, Nieuwegein, The Netherlands., Jo H; Department of Respiratory Medicine, Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia., De Liperi A; Department of Radiology, Pisa University Hospital, Pisa, Italy., Duncan M; Department of Radiology, University College London Hospitals NHS Foundation Trust, London, UK., Pontoppidan K; NIHR Southampton Biomedical Research Centre and Clinical and Experimental Sciences, University of Southampton, Southampton, UK., De Sadeleer LJ; Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium.; Institute of Lung Health and Immunity (LHI)/Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München, Munich, Germany., van Beek F; Interstitial Lung Diseases Center of Excellence, Department of Pulmonology, St Antonius Hospital, Nieuwegein, The Netherlands., Barnett J; Department of Radiology, Royal Free London NHS Foundation Trust, London, UK., Cross G; Department of Radiology, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK., Procter A; Department of Radiology, University College London Hospitals NHS Foundation Trust, London, UK., Veltkamp M; Interstitial Lung Diseases Center of Excellence, Department of Pulmonology, St Antonius Hospital, Nieuwegein, The Netherlands.; Division of Heart and Lungs, University Medical Center, Utrecht, The Netherlands., Hopkins P; Queensland Centre for Pulmonary Transplantation and Vascular Disease, The Prince Charles Hospital, Chermside, Australia., Moodley Y; School of Medicine and Pharmacology, University Western Australia, Perth, Australia.; Fiona Stanley Hospital, Perth, Australia., Taliani A; Department of Radiology, Pisa University Hospital, Pisa, Italy., Taylor M; Department of Radiology, University College London Hospitals NHS Foundation Trust, London, UK., Verleden S; Antwerp Surgical Training, Anatomy and Research Centre (ASTARC), Faculty of Medicine and Health Sciences, University of Antwerp, Edegem, Belgium., Tavanti L; Cardiovascular and Thoracic Department, Pisa University Hospital, Pisa, Italy., Vermant M; BREATHE, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.; Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium., Nair A; Department of Radiology, University College London Hospitals NHS Foundation Trust, London, UK., Stewart I; National Heart and Lung Institute, Imperial College London, London, UK., Janes SM; Lungs for Living Research Centre, UCL, London, UK., Young AL; Centre for Medical Image Computing, UCL, London, UK.; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Barber D; Centre for Artificial Intelligence, UCL, London, UK., Alexander DC; Centre for Medical Image Computing, UCL, London, UK., Porter JC; Interstitial Lung Disease Service, Department of Respiratory Medicine, University College London Hospitals NHS Foundation Trust, London, UK., Wells AU; Department of Respiratory Medicine, Royal Brompton Hospital, London, UK.; Imperial College London, London, UK., Jones MG; NIHR Southampton Biomedical Research Centre and Clinical and Experimental Sciences, University of Southampton, Southampton, UK., Wuyts WA; BREATHE, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.; Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium., Jacob J; Satsuma Lab, Centre for Medical Image Computing, UCL, London, UK j.jacob@ucl.ac.uk.; Centre for Medical Image Computing, UCL, London, UK.; Lungs for Living Research Centre, UCL, London, UK. |
| المصدر: | The European respiratory journal [Eur Respir J] 2024 Apr 04; Vol. 63 (4). Date of Electronic Publication: 2024 Apr 04 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: European Respiratory Society Country of Publication: England NLM ID: 8803460 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1399-3003 (Electronic) Linking ISSN: 09031936 NLM ISO Abbreviation: Eur Respir J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Sheffield, United Kingdom : European Respiratory Society Original Publication: Copenhagen : Published jointly by the Society and Munksgaard, 1988- |
| مواضيع طبية MeSH: | Pulmonary Emphysema*/complications , Idiopathic Pulmonary Fibrosis* , Emphysema*/complications, Humans ; Lung ; Fibrosis ; Disease Progression ; Retrospective Studies |
| مستخلص: | Background: Idiopathic pulmonary fibrosis (IPF) with coexistent emphysema, termed combined pulmonary fibrosis and emphysema (CPFE) may associate with reduced forced vital capacity (FVC) declines compared to non-CPFE IPF patients. We examined associations between mortality and functional measures of disease progression in two IPF cohorts. Methods: Visual emphysema presence (>0% emphysema) scored on computed tomography identified CPFE patients (CPFE/non-CPFE: derivation cohort n=317/n=183, replication cohort n=358/n=152), who were subgrouped using 10% or 15% visual emphysema thresholds, and an unsupervised machine-learning model considering emphysema and interstitial lung disease extents. Baseline characteristics, 1-year relative FVC and diffusing capacity of the lung for carbon monoxide ( D Results: In both IPF cohorts, CPFE patients with ≥10% emphysema had a greater smoking history and lower baseline D Conclusion: When assessing disease progression in IPF, D Competing Interests: Conflict of interest: J. Jacob reports fees from Boehringer Ingelheim, Roche, NHSX, Takeda and GlaxoSmithKline, unrelated to the submitted work, and was supported by Wellcome Trust Clinical Research Career Development Fellowship 209553/Z/17/Z and the NIHR Biomedical Research Centre at University College London. N. Mogulkoc reports grant TUBITAK (EJP Rare Disease project “COCOS-IPF”), fees from Boehringer Ingelheim, Roche, and Nobel Turkey unrelated to the submitted work, and received support for travel to meetings from Roche and Actelion. T.J. Corte reports unrestricted educational grants from Boehringer Ingelheim, Roche, Biogen and Galapagos, fees from Roche, BMS, Boehringer Ingelheim, Vicore and DevPro, assistance for travel to meetings from Boehringer Ingelheim, and participation on a data safety monitoring board or advisory board for Roche, BMS, Boehringer Ingelheim, Vicore, Ad Alta, Bridge Biotherapeutics and DevPro. P. Vasudev reports financial interests from Blackford Analysis. T. Goos is supported by Research Foundation Flanders (1S73921N). L.J. De Sadeleer is supported by Marie Sklodowska-Curie actions postdoctoral fellowship within the European Union's Horizon Europe research and innovation programme. H. Jo reports fees from Boehringer Ingelheim and Roche, and received assistance for travel to meetings from Boehringer Ingelheim and Roche. S. Verleden reports consultancy fees from Boehringer Ingelheim and Sanofi. M. Vermant is supported by an FWO (Research Flanders Foundation) fellowship. S.M. Janes reports fees from AstraZeneca, Bard1 Bioscience, Achilles Therapeutics and Jansen unrelated to the submitted work, received assistance for travel to meetings from AstraZeneca and Takeda, and is the investigator lead on grants from GRAIL Inc., GlaxoSmithKline plc and Owlstone. A.U. Wells reports personal fees and non-financial support from Boehringer Ingelheim, Bayer and Roche Pharmaceuticals, and personal fees from Blade, outside of the submitted work. The remaining authors report no relevant conflicts of interest. (Copyright ©The authors 2024. For reproduction rights and permissions contact permissions@ersnet.org.) |
| التعليقات: | Comment in: Eur Respir J. 2024 Apr 4;63(4):2400353. doi: 10.1183/13993003.00353-2024. (PMID: 38575167) |
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| معلومات مُعتمدة: | United Kingdom WT_ Wellcome Trust; 209553 United Kingdom WT_ Wellcome Trust; MR/T027800/1 United Kingdom MRC_ Medical Research Council |
| تواريخ الأحداث: | Date Created: 20231116 Date Completed: 20240408 Latest Revision: 20240617 |
| رمز التحديث: | 20240617 |
| مُعرف محوري في PubMed: | PMC7616106 |
| DOI: | 10.1183/13993003.00127-2023 |
| PMID: | 37973176 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1399-3003 |
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| DOI: | 10.1183/13993003.00127-2023 |