دورية أكاديمية
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Associations Between Structural Covariance Network and Antipsychotic Treatment Response in Schizophrenia.

التفاصيل البيبلوغرافية
العنوان: Associations Between Structural Covariance Network and Antipsychotic Treatment Response in Schizophrenia.
المؤلفون: Tsugawa S; Department of Neuropsychiatry, Keio University, Tokyo, Japan., Honda S; Department of Neuropsychiatry, Keio University, Tokyo, Japan., Noda Y; Department of Neuropsychiatry, Keio University, Tokyo, Japan., Wannan C; Department of Psychiatry, University of Melbourne, Melbourne, Australia., Zalesky A; Department of Biomedical Engineering, Melbourne School of Engineering, the University of Melbourne, Melbourne, Australia., Tarumi R; Department of Neuropsychiatry, Keio University, Tokyo, Japan.; Department of Psychiatry, Komagino Hospital, Tokyo, Japan., Iwata Y; Department of Neuropsychiatry, University of Yamanashi, Yamanashi, Japan., Ogyu K; Department of Neuropsychiatry, Keio University, Tokyo, Japan.; Department of Psychiatry, National Hospital Organization Shimofusa Psychiatric Medical Center, Chiba, Japan., Plitman E; Department of Psychiatry, McGill University, Montreal, QC, Canada., Ueno F; Department of Neuropsychiatry, Keio University, Tokyo, Japan.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada., Mimura M; Department of Neuropsychiatry, Keio University, Tokyo, Japan., Uchida H; Department of Neuropsychiatry, Keio University, Tokyo, Japan., Chakravarty M; Department of Psychiatry, McGill University, Montreal, QC, Canada.; Computational Brain Anatomy Laboratory, Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, QC, Canada., Graff-Guerrero A; Department of Psychiatry, University of Toronto, Toronto, ON, Canada., Nakajima S; Department of Neuropsychiatry, Keio University, Tokyo, Japan.
المصدر: Schizophrenia bulletin [Schizophr Bull] 2024 Mar 07; Vol. 50 (2), pp. 382-392.
نوع المنشور: Multicenter Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0236760 Publication Model: Print Cited Medium: Internet ISSN: 1745-1701 (Electronic) Linking ISSN: 05867614 NLM ISO Abbreviation: Schizophr Bull Subsets: MEDLINE
أسماء مطبوعة: Publication: 2005- : Cary, NC : Oxford University Press
Original Publication: [Chevy Chase, Md., For sale by the Supt. of Docs., U. S. Govt. Print. Off. Washington]
مواضيع طبية MeSH: Schizophrenia*/diagnostic imaging , Schizophrenia*/drug therapy , Schizophrenia*/pathology , Antipsychotic Agents*/pharmacology , Antipsychotic Agents*/therapeutic use, Humans ; Cerebral Cortical Thinning ; Brain/pathology ; Magnetic Resonance Imaging/methods
مستخلص: Background and Hypothesis: Schizophrenia is associated with widespread cortical thinning and abnormality in the structural covariance network, which may reflect connectome alterations due to treatment effect or disease progression. Notably, patients with treatment-resistant schizophrenia (TRS) have stronger and more widespread cortical thinning, but it remains unclear whether structural covariance is associated with treatment response in schizophrenia.
Study Design: We organized a multicenter magnetic resonance imaging study to assess structural covariance in a large population of TRS and non-TRS, who had been resistant and responsive to non-clozapine antipsychotics, respectively. Whole-brain structural covariance for cortical thickness was assessed in 102 patients with TRS, 77 patients with non-TRS, and 79 healthy controls (HC). Network-based statistics were used to examine the difference in structural covariance networks among the 3 groups. Moreover, the relationship between altered individual differentiated structural covariance and clinico-demographics was also explored.
Study Results: Patients with non-TRS exhibited greater structural covariance compared with HC, mainly in the fronto-temporal and fronto-occipital regions, while there were no significant differences in structural covariance between TRS and non-TRS or HC. Higher individual differentiated structural covariance was associated with lower general scores of the Positive and Negative Syndrome Scale in the non-TRS group, but not in the TRS group.
Conclusions: These findings suggest that reconfiguration of brain networks via coordinated cortical thinning is related to treatment response in schizophrenia. Further longitudinal studies are warranted to confirm if greater structural covariance could serve as a marker for treatment response in this disease.
(© The Author(s) 2023. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
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معلومات مُعتمدة: MOP-142493 Canada CAPMC CIHR; MOP-142493 Canada CAPMC CIHR
فهرسة مساهمة: Keywords: cortical thickness; individual differential structural covariance network; magnetic resonance imaging; multicenter; structural covariance; treatment-resistant schizophrenia
المشرفين على المادة: 0 (Antipsychotic Agents)
تواريخ الأحداث: Date Created: 20231117 Date Completed: 20240311 Latest Revision: 20240311
رمز التحديث: 20240311
مُعرف محوري في PubMed: PMC10919786
DOI: 10.1093/schbul/sbad160
PMID: 37978044
قاعدة البيانات: MEDLINE
الوصف
تدمد:1745-1701
DOI:10.1093/schbul/sbad160