دورية أكاديمية
أعرض في EDS

Sex differences in patients with primary hyperparathyroidism.

التفاصيل البيبلوغرافية
العنوان: Sex differences in patients with primary hyperparathyroidism.
المؤلفون: Baugh KA; Department of Surgery, University of Pittsburgh, Pittsburgh, PA. Electronic address: baughk@upmc.edu., Liu JB; Department of Surgery, Brigham and Women's Hospital, Boston, MA., Yip L; Department of Surgery, University of Pittsburgh, Pittsburgh, PA., McCoy KL; Department of Surgery, University of Pittsburgh, Pittsburgh, PA., Carty SE; Department of Surgery, University of Pittsburgh, Pittsburgh, PA., Ramonell KM; Department of Surgery, University of Pittsburgh, Pittsburgh, PA.
المصدر: Surgery [Surgery] 2024 Jan; Vol. 175 (1), pp. 65-72. Date of Electronic Publication: 2023 Nov 18.
نوع المنشور: Review; Journal Article
اللغة: English
بيانات الدورية: Publisher: Mosby Country of Publication: United States NLM ID: 0417347 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-7361 (Electronic) Linking ISSN: 00396060 NLM ISO Abbreviation: Surgery Subsets: MEDLINE
أسماء مطبوعة: Publication: St. Louis, MO : Mosby
Original Publication: St. Louis.
مواضيع طبية MeSH: Hyperparathyroidism, Primary*/surgery, Humans ; Male ; Female ; Quality of Life ; Sex Characteristics ; Prospective Studies ; Parathyroidectomy
مستخلص: Background: Differences in presenting symptoms of primary hyperparathyroidism and outcomes of parathyroidectomy between sexes have been described, but whether these can be assessed by perioperative use of a validated tool, such as the Pasieka Parathyroidectomy Assessment Score, is unknown.
Method: All patients with primary hyperparathyroidism were asked to complete symptom assessment at the preoperative and postoperative visits. The assessment included a query for 13 Pasieka Parathyroidectomy Assessment Score parameters evaluated using a visual analog scale as described by Pasieka (summative score 0-1,300), and general quality of life and wellness. A review of a prospectively maintained database of primary hyperparathyroidism patients (January 2016-December 2019) was performed, and those who had a 6-month cure after initial parathyroidectomy were included.
Results: The study cohort was mostly women (77%, 541/701). The median preoperative Pasieka Parathyroidectomy Assessment Score was higher in women (155, 0-1,190) than in men (80.5, 0-855, P < .001), although there were similar rates of asymptomatic primary hyperparathyroidism (Pasieka Parathyroidectomy Assessment Score = 0, 12.5% vs 7%, P = .042). After curative parathyroidectomy, women reported a substantial reduction in symptomatology, with Pasieka Parathyroidectomy Assessment Score declining by 35% at initial postoperative visit (median, 155 vs 100, P < .001), further decreasing to 48% by 6 months (155 vs 80, P < .001). The Pasieka Parathyroidectomy Assessment Score in men did change but to a much smaller degree at both the initial postoperative visit (80.5 vs 70; P = .036) and at 6 months (80.5 vs 57.5; P = .048).
Conclusion: When assessed with the Pasieka Parathyroidectomy Assessment Score, improvement in symptoms was clearly demonstrated for women after curative parathyroidectomy. Whether symptom improvement also occurs in men is less apparent but may be due to disparities in the development and validation of outcomes tools in general.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
تواريخ الأحداث: Date Created: 20231118 Date Completed: 20231216 Latest Revision: 20240201
رمز التحديث: 20240201
DOI: 10.1016/j.surg.2023.07.044
PMID: 37980200
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-7361
DOI:10.1016/j.surg.2023.07.044