دورية أكاديمية
Secondary hypogammaglobulinemia in adults-A large retrospective cohort study.
| العنوان: | Secondary hypogammaglobulinemia in adults-A large retrospective cohort study. |
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| المؤلفون: | Angarola E; Internal Medicine Department, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. Electronic address: ernestina.angarola@hospitalitaliano.org.ar., Peuchot VA; Clinical Research Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Warley F; Hematology Section, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Liberatore DI; Immunology Section, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. |
| المصدر: | Medicina clinica [Med Clin (Barc)] 2024 Feb 23; Vol. 162 (4), pp. 170-178. Date of Electronic Publication: 2023 Nov 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English; Spanish; Castilian |
| بيانات الدورية: | Publisher: Elsevier España Country of Publication: Spain NLM ID: 0376377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1578-8989 (Electronic) Linking ISSN: 00257753 NLM ISO Abbreviation: Med Clin (Barc) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2009- > : Madrid : Elsevier España Original Publication: Barcelona : Ediciones Doyma, S.A. |
| مواضيع طبية MeSH: | Agammaglobulinemia*/complications , Agammaglobulinemia*/diagnosis , Agammaglobulinemia*/epidemiology , Common Variable Immunodeficiency*/complications , Respiratory Tract Infections*/complications , Respiratory Tract Infections*/epidemiology , Lymphoma*/drug therapy, Adult ; Humans ; Immunoglobulin G ; Retrospective Studies |
| مستخلص: | Background and Objective: IgG replacement therapy (IgG-RT) has radically changed the clinical evolution of primary immunodeficiencies, yet the information regarding secondary hypogammaglobulinemia (SHG) is insufficient or conflicting. We aim to describe clinical features, evolution and treatment of SHG patients in our center. Methods: Dynamic retrospective cohort between January 2001 and July 2021 of adults with gamma globulin fraction <0.6g/dL in a serum protein electrophoresis and a coincident decrease of IgG levels - with a disease-related SHG or treatment that reduces serum immunoglobulins. Results: We included 1012 patients with SHG with a median follow-up of 5 years (IQR 2-8). Hematological diseases were identified in 95% of the patients and 61% received drugs related to SHG. Sixty five percent had more than one etiological factor associated with SHG. Infectious diseases were present in 69% of the patients, 48% had respiratory infections and 17% had severe infections. There was statistical association between respiratory and severe infections with multiple myeloma (MM), lymphoma and rituximab. MGUS had less infections and death compared with other etiologies. IgG-RT was indicated in 18.7% of the patients and 4.6% received it for more than 6 months with variable intervals. Among the latter group, there was a significant reduction of all-type infections and respiratory infections with IgG-RT (p<0.001), and it was consistent with similar findings in lymphoma, MM and all IgG levels subgroups. Conclusion: SHG was associated with more than one etiological factor and a high frequency of infections. IgG-RT indication was irregular yet still effective. It is relevant to consider IgG levels screening, monitoring and accurate indication of IgG-RT. (Copyright © 2023 Elsevier España, S.L.U. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Hematologic neoplasms; Hipogammaglobulinemia secundaria; Immunosuppression; Inmunosupresión; Neoplasias hematológicas; Neumonía; Pneumonia; Secondary hypogammaglobulinemia; Transplantation; Trasplante |
| المشرفين على المادة: | 0 (Immunoglobulin G) |
| تواريخ الأحداث: | Date Created: 20231118 Date Completed: 20240216 Latest Revision: 20240326 |
| رمز التحديث: | 20240327 |
| DOI: | 10.1016/j.medcli.2023.10.005 |
| PMID: | 37980212 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1578-8989 |
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| DOI: | 10.1016/j.medcli.2023.10.005 |