دورية أكاديمية
Pituitary pars intermedia dysfunction with pituitary gland melanotroph adenoma in a Grevy's zebra (Equus grevyi).
| العنوان: | Pituitary pars intermedia dysfunction with pituitary gland melanotroph adenoma in a Grevy's zebra (Equus grevyi). |
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| المؤلفون: | Takahashi N; Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan., Chambers JK; Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan., Ota K; Tama Zoological Park, Tokyo Zoological Park Society, Tokyo, Japan., Toda K; Tama Zoological Park, Tokyo Zoological Park Society, Tokyo, Japan., Yoshimoto Y; Tama Zoological Park, Tokyo Zoological Park Society, Tokyo, Japan., Miyajima U; Tama Zoological Park, Tokyo Zoological Park Society, Tokyo, Japan., Uchida K; Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan. |
| المصدر: | The Journal of veterinary medical science [J Vet Med Sci] 2024 Jan 10; Vol. 86 (1), pp. 71-76. Date of Electronic Publication: 2023 Nov 20. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Japanese Society Of Veterinary Science Country of Publication: Japan NLM ID: 9105360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1347-7439 (Electronic) Linking ISSN: 09167250 NLM ISO Abbreviation: J Vet Med Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Tokyo : Japanese Society Of Veterinary Science |
| مواضيع طبية MeSH: | Pituitary Neoplasms*/veterinary , Adenoma*/veterinary , Adenoma*/pathology, Female ; Animals ; Melanotrophs/metabolism ; Melanotrophs/pathology ; Amyloid beta-Peptides ; Equidae ; Pituitary Gland/metabolism ; Adrenocorticotropic Hormone/metabolism |
| مستخلص: | A 22-year and 9-month-old female Grevy's zebra (Equus grevyi) showed signs of polyuria, polydipsia, glucosuria, and muscle atrophy. Blood tests revealed hyperglycemia, hypertriglyceridemia, electrolyte imbalance, high levels of adrenocorticotropic hormone (ACTH) and cortisol, and low levels of hormones secreted by the pituitary pars distalis. Pathological examinations revealed a pituitary gland tumor and bilateral adrenal cortical hyperplasia. Pituitary tumor cells showed immunoreactivity for α-melanocyte-stimulating hormone and ACTH. The deposition of amyloid β was observed in the parenchyma and vascular walls of the cerebrum. The zebra showed clinical signs of pituitary pars intermedia dysfunction and was histopathologically diagnosed with pituitary gland melanotroph adenoma. This case report provides insight into neoplastic and endocrine diseases associated with the aging of a zebra. |
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| فهرسة مساهمة: | Keywords: Grevy’s zebra; melanotroph adenoma; pituitary pars intermedia dysfunction |
| المشرفين على المادة: | 0 (Amyloid beta-Peptides) 9002-60-2 (Adrenocorticotropic Hormone) |
| تواريخ الأحداث: | Date Created: 20231119 Date Completed: 20240112 Latest Revision: 20240210 |
| رمز التحديث: | 20240210 |
| مُعرف محوري في PubMed: | PMC10849860 |
| DOI: | 10.1292/jvms.23-0177 |
| PMID: | 37981318 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1347-7439 |
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| DOI: | 10.1292/jvms.23-0177 |