دورية أكاديمية
أعرض في EDS

Maintenance of appropriate size scaling of the C. elegans pharynx by YAP-1.

التفاصيل البيبلوغرافية
العنوان: Maintenance of appropriate size scaling of the C. elegans pharynx by YAP-1.
المؤلفون: Stojanovski K; Institute of Cell Biology, University of Bern, Bern, Switzerland., Gheorghe I; Institute of Cell Biology, University of Bern, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland., Lenart P; Institute of Cell Biology, University of Bern, Bern, Switzerland., Lanjuin A; Department Molecular Metabolism, Harvard TH Chan School of Public Health, Boston, MA, USA., Mair WB; Department Molecular Metabolism, Harvard TH Chan School of Public Health, Boston, MA, USA., Towbin BD; Institute of Cell Biology, University of Bern, Bern, Switzerland. benjamin.towbin@unibe.ch.
المصدر: Nature communications [Nat Commun] 2023 Nov 20; Vol. 14 (1), pp. 7564. Date of Electronic Publication: 2023 Nov 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Caenorhabditis elegans*/genetics , Caenorhabditis elegans Proteins*/genetics , Caenorhabditis elegans Proteins*/metabolism, Humans ; Animals ; Pharynx/metabolism ; Mechanotransduction, Cellular ; YAP-Signaling Proteins
مستخلص: Even slight imbalance between the growth rate of different organs can accumulate to a large deviation from their appropriate size during development. Here, we use live imaging of the pharynx of C. elegans to ask if and how organ size scaling nevertheless remains uniform among individuals. Growth trajectories of hundreds of individuals reveal that pharynxes grow by a near constant volume per larval stage that is independent of their initial size, such that undersized pharynxes catch-up in size during development. Tissue-specific depletion of RAGA-1, an activator of mTOR and growth, shows that maintaining correct pharynx-to-body size proportions involves a bi-directional coupling between pharynx size and body growth. In simulations, this coupling cannot be explained by limitation of food uptake alone, and genetic experiments reveal an involvement of the mechanotransducing transcriptional co-regulator yap-1. Our data suggests that mechanotransduction coordinates pharynx growth with other tissues, ensuring body plan uniformity among individuals.
(© 2023. The Author(s).)
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معلومات مُعتمدة: P40 OD010440 United States OD NIH HHS; R01 AG044346 United States AG NIA NIH HHS; R01 AG059595 United States AG NIA NIH HHS
المشرفين على المادة: 0 (Caenorhabditis elegans Proteins)
0 (YAP-1 protein, C elegans)
0 (YAP-Signaling Proteins)
تواريخ الأحداث: Date Created: 20231120 Date Completed: 20231122 Latest Revision: 20240210
رمز التحديث: 20240210
مُعرف محوري في PubMed: PMC10661912
DOI: 10.1038/s41467-023-43230-1
PMID: 37985670
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-023-43230-1