دورية أكاديمية
Hypereosinophilic syndrome with massive liver infarction: A case report.
| العنوان: | Hypereosinophilic syndrome with massive liver infarction: A case report. |
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| المؤلفون: | Lu SY; Department of Radiology, Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, P.R. China., Hua YF, Guo L |
| المصدر: | Medicine [Medicine (Baltimore)] 2023 Nov 17; Vol. 102 (46), pp. e35903. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins |
| مواضيع طبية MeSH: | Hepatic Infarction*/complications , Hypereosinophilic Syndrome*/complications , Hypereosinophilic Syndrome*/diagnosis , Hypereosinophilic Syndrome*/therapy , Liver Diseases*/complications , Thrombosis*/complications, Humans ; Male ; Young Adult ; Glucocorticoids/therapeutic use |
| مستخلص: | Rationale: Liver infarction caused only by hepatic artery occlusion is rare. Elevated levels of eosinophils in the blood and tissue can have devastating consequences. Patient Concerns: Male, 21 years old, presented with persistent abdominal distension and discomfort for more than ten days without an apparent cause. Laboratory findings showed an eosinophil percentage of 32.5% (normal range 0.5%-5%). Computed tomographic angiography of the hepatic artery and its branches did not show any enhancement, only the common hepatic artery was visible. Diagnosis: The patient in this case had a peripheral blood eosinophil count of ≥1.5 × 109/L in multiple examinations over 6 months, and eosinophilic leukemia and secondary causes such as parasitic infections, allergic diseases, or tumors were ruled out, confirming the diagnosis of hypereosinophilic syndrome (HES). Interventions: The patients were treated with interventional therapy, glucocorticoid pulse therapy and anti-infection therapy. Outcomes: After interventional therapy, glucocorticoid pulse therapy, and anti-infection treatment, the patient was reexamined 2 months later. The CT scan showed that the range of the original infarction in the liver had shrunk compared to before, and the remaining liver had enlarged with good compensation; Laboratory tests improved compared with baseline: eosinophil percentage of 0.1%. Lessons: This article discusses a rare case of hepatic artery occlusion and liver infarction in a young male patient with HES. The cause of hepatic artery embolism and hepatic infarction may be related to the abnormal increase in eosinophils, which can lead to hypercoagulation and thrombus formation. The article emphasizes the importance of timely diagnosis and treatment of HES to prevent life-threatening thrombotic events and describes the successful management of the patient condition through anticoagulation, anti-infection, liver protection, and glucocorticoid therapy. Competing Interests: The authors have no funding and conflicts of interest to disclose. (Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.) |
| References: | Valent P, Klion AD, Roufosse F, et al. Proposed refined diagnostic criteria and classification of eosinophil disorders and related syndromes. Allergy. 2023;78:47–59. Réau V, Vallée A, Terrier B, et al. Venous thrombosis and predictors of relapse in eosinophil-related diseases. Sci Rep. 2021;11:6388. Liu Y, Meng X, Feng J, et al. Hypereosinophilia with concurrent venous thromboembolism: clinical features, potential risk factors, and short-term outcomes in a Chinese Cohort. Sci Rep. 2020;10:8359. Ryan D, Inamullah O, El Husseini N, et al. The hypereosinophilic syndrome - an unusual cause of myocarditis and cardioembolic strokes. Am J Med Sci. 2022;364:661–8. Cioclu MC, Cavallieri F, Napoli M, et al. Mechanisms and neuroimaging patterns of hypereosinophilia-related ischemic stroke: a narrative review through three cases. J Clin Med. 2022;11:5595. |
| المشرفين على المادة: | 0 (Glucocorticoids) |
| تواريخ الأحداث: | Date Created: 20231121 Date Completed: 20231201 Latest Revision: 20231201 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10659708 |
| DOI: | 10.1097/MD.0000000000035903 |
| PMID: | 37986393 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1536-5964 |
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| DOI: | 10.1097/MD.0000000000035903 |