Associations between regional adipose tissue distribution and skeletal muscle bioenergetics in older men and women.
العنوان: | Associations between regional adipose tissue distribution and skeletal muscle bioenergetics in older men and women. |
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المؤلفون: | Brennan AM, Coen PM, Mau T, Hetherington-Rauth M, Toledo FGS, Kershaw EE, Cawthon PM, Kramer PA, Ramos SV, Newman AB, Cummings SR, Forman DE, Yeo RX, DiStefano G, Miljkovic I, Justice JN, Molina AJA, Jurczak MJ, Sparks LM, Kritchevsky SB, Goodpaster BH |
المصدر: | MedRxiv : the preprint server for health sciences [medRxiv] 2023 Nov 10. Date of Electronic Publication: 2023 Nov 10. |
نوع المنشور: | Preprint |
اللغة: | English |
بيانات الدورية: | Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
مستخلص: | Objective: Examine the association of ectopic adipose tissue (AT) with skeletal muscle (SM) mitochondrial bioenergetics in older adults. Methods: Cross-sectional data from 829 older adults ≥70 years was used. Total abdominal, subcutaneous, and visceral AT; and thigh muscle fat infiltration (MFI) was quantified by MRI. SM mitochondrial energetics were characterized using in vivo 31 P-MRS (ATP Results: Independent of BMI, total abdominal (standardized (Std.) β=-0.21; R 2 =0.09) and visceral AT (Std. β=-0.16; R 2 =0.09) were associated with ATP Conclusions: Skeletal MFI and abdominal visceral, but not subcutaneous AT, are inversely associated with SM mitochondrial bioenergetics in older adults independent of BMI. Associations between ectopic AT and in vivo mitochondrial bioenergetics are attenuated by PA. |
التعليقات: | Update in: Obesity (Silver Spring). 2024 Jun;32(6):1125-1135. doi: 10.1002/oby.24008. (PMID: 38803308) |
تواريخ الأحداث: | Date Created: 20231121 Latest Revision: 20240806 |
رمز التحديث: | 20240807 |
مُعرف محوري في PubMed: | PMC10659498 |
DOI: | 10.1101/2023.11.10.23298359 |
PMID: | 37986822 |
قاعدة البيانات: | MEDLINE |
DOI: | 10.1101/2023.11.10.23298359 |
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