دورية أكاديمية
Adverse effect of Tamarindus indica and tamoxifen combination on redox balance and genotoxicity of breast cancer cell.
| العنوان: | Adverse effect of Tamarindus indica and tamoxifen combination on redox balance and genotoxicity of breast cancer cell. |
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| المؤلفون: | Guneidy RA; Department of Molecular Biology, Biotechnology Research Institute, National Research Centre, Cairo, Egypt. rasha_a_m_g@hotmail.com., Zaki ER; Department of Molecular Biology, Biotechnology Research Institute, National Research Centre, Cairo, Egypt., Karim GSAA; Department of Molecular Biology, Biotechnology Research Institute, National Research Centre, Cairo, Egypt., Saleh NS; Department of Molecular Biology, Biotechnology Research Institute, National Research Centre, Cairo, Egypt., Shokeer A; Department of Molecular Biology, Biotechnology Research Institute, National Research Centre, Cairo, Egypt. |
| المصدر: | Journal, genetic engineering & biotechnology [J Genet Eng Biotechnol] 2023 Nov 21; Vol. 21 (1), pp. 131. Date of Electronic Publication: 2023 Nov 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101317150 Publication Model: Electronic Cited Medium: Internet ISSN: 2090-5920 (Electronic) Linking ISSN: 1687157X NLM ISO Abbreviation: J Genet Eng Biotechnol |
| أسماء مطبوعة: | Publication: 2024- : [Amsterdam, Netherlands] : Elsevier B.V. Original Publication: [Cairo] : Academy of Scientific Research and Technology, Information and Scientific Services Sector, National Information and Documentation Center |
| مستخلص: | Background: Breast cancer is the most significant threat to women worldwide. Most chemotherapeutic drugs cause cancer cell death and apoptosis by inducing oxidative stress and producing reactive oxygen species (ROS). Cancer cells have a higher rate of metabolic activity than normal cells and thus produce more ROS. Glutathione and its related enzymes are the most significant antioxidant defense mechanisms that protect cells from oxidative and chemotherapeutic impacts. The anticancer actions of phenolic compounds were greatly confirmed. Using phenolic compounds as drugs in combination with chemotherapy may improve health, improve treatment outcomes, and reduce dose and damage. The goal of the study was to treat breast cancer cell lines (MCF-7) with Tamarindus indica extract individually and in combination with the anticancer drug tamoxifen (TAM) to improve therapeutic efficacy. Results: After 48 h of incubation at IC Conclusion: Cytotoxic and genotoxic effect of treatment with T. indica extract could be attributed to the dynamic interaction of glutathione cycle and antioxidant enzymes to combat oxidative stress, which can be considered as a positive therapeutic effect. On the other hand, the negative response of tamoxifen efficacy when co-treated with T. indica reversed tamoxifen's genotoxicity and enhanced survival. (© 2023. The Author(s).) |
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| معلومات مُعتمدة: | 121104 National research centre, Cairo, Egypt |
| فهرسة مساهمة: | Keywords: Breast cancer; Combination treatment; Genotoxicity; Glutathione-related enzymes; Oxidative stress; Plant cytotoxicity; Tamoxifen |
| تواريخ الأحداث: | Date Created: 20231121 Latest Revision: 20231124 |
| رمز التحديث: | 20231124 |
| مُعرف محوري في PubMed: | PMC10663423 |
| DOI: | 10.1186/s43141-023-00564-z |
| PMID: | 37987952 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2090-5920 |
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| DOI: | 10.1186/s43141-023-00564-z |