دورية أكاديمية
أعرض في EDS

Effective early strategy to prevent olfactory and gustatory dysfunction in COVID-19: a randomized controlled trial.

التفاصيل البيبلوغرافية
العنوان: Effective early strategy to prevent olfactory and gustatory dysfunction in COVID-19: a randomized controlled trial.
المؤلفون: Jing Q; Department of Anesthesiology and Perioperative Medicine, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China., Song J; Department of Anesthesiology and Perioperative Medicine, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China., An G; Department of Anesthesiology and Perioperative Medicine, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China., Zhu E; Department of Medical Statistics, Tongji University School of Medicine, Shanghai 200092, China., Ai Z; Department of Medical Statistics, Tongji University School of Medicine, Shanghai 200092, China., Xiong L; Department of Anesthesiology and Perioperative Medicine, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China., Li C; Department of Anesthesiology and Perioperative Medicine, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China.
المصدر: QJM : monthly journal of the Association of Physicians [QJM] 2024 Jun 04; Vol. 117 (5), pp. 348-352.
نوع المنشور: Journal Article; Randomized Controlled Trial; Multicenter Study
اللغة: English
بيانات الدورية: Publisher: Published for the Association of Physicians of Great Britain and Ireland by the Oxford University Press Country of Publication: England NLM ID: 9438285 Publication Model: Print Cited Medium: Internet ISSN: 1460-2393 (Electronic) Linking ISSN: 14602393 NLM ISO Abbreviation: QJM Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Oxford] : Published for the Association of Physicians of Great Britain and Ireland by the Oxford University Press, c1994-
مواضيع طبية MeSH: COVID-19*/complications , Olfaction Disorders*/etiology , Olfaction Disorders*/prevention & control , Chlorhexidine*/analogs & derivatives , Chlorhexidine*/therapeutic use , Chlorhexidine*/administration & dosage , Mouthwashes*/therapeutic use , Mouthwashes*/administration & dosage , Taste Disorders*/etiology , Taste Disorders*/prevention & control, Humans ; Female ; Male ; Double-Blind Method ; Middle Aged ; Adult ; SARS-CoV-2 ; Nasal Sprays ; Aged ; Nasal Lavage/methods ; Saline Solution/administration & dosage ; Saline Solution/therapeutic use ; Treatment Outcome
مستخلص: Background: Olfactory and gustatory dysfunctions (OGDs) are key symptoms of coronavirus disease 2019 (COVID-19), which may lead to neurological complications, and lack of effective treatment. This may be because post-disease treatments may be too late to protect the olfactory and gustatory functions.
Aim: To evaluate the effectiveness of early use of saline nasal irrigation (SNI), corticosteroid nasal spray, and saline or chlorhexidine gluconate mouthwash for preventing OGDs in COVID-19.
Design: This study was a double-blind randomized controlled trial.
Methods: The study was conducted from 5 May to 16 June 2022. We recruited patients from three hospitals who were admitted with COVID-19 but without OGDs on the day of admission. Olfactory and gustatory functions were evaluated using the Taste and Smell Survey and the numerical visual analog scale. Participants were randomized to the saline, drug or control groups. The control group received no intervention, saline group received SNI plus saline nasal spray and mouthwash, and the trial group received SNI plus budesonide nasal spray and chlorhexidine gluconate mouthwash. Participants were assessed again on the day of discharge.
Results: A total of 379 patients completed the trial. The prevalence of OGDs was significantly lower in the saline (11.8%, 95% CI, 6.6-19.0%; P < 0.001) and drug (8.3%, 95% CI, 4.1-14.8%; P < 0.001) groups than in the control group (40.0%, 95% CI, 31.8-48.6%). Additionally, both interventions reduced the severity of OGDs.
Conclusions: We demonstrated effective strategies for preventing COVID-19-related OGDs, and the findings may guide early management of severe acute respiratory disease coronavirus 2 (SARS-CoV-2) infection to reduce the incidence of COVID-19-related complications.
(© The Author(s) 2023. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
معلومات مُعتمدة: 82271223 National Natural Science Foundation of China
المشرفين على المادة: R4KO0DY52L (Chlorhexidine)
0 (Mouthwashes)
0 (Nasal Sprays)
MOR84MUD8E (chlorhexidine gluconate)
0 (Saline Solution)
تواريخ الأحداث: Date Created: 20231121 Date Completed: 20240604 Latest Revision: 20240717
رمز التحديث: 20240718
DOI: 10.1093/qjmed/hcad262
PMID: 37988146
قاعدة البيانات: MEDLINE
الوصف
تدمد:1460-2393
DOI:10.1093/qjmed/hcad262