دورية أكاديمية
أعرض في EDS

IL-10-induced STAT3/NF-κB crosstalk modulates pineal and extra-pineal melatonin synthesis.

التفاصيل البيبلوغرافية
العنوان: IL-10-induced STAT3/NF-κB crosstalk modulates pineal and extra-pineal melatonin synthesis.
المؤلفون: Córdoba-Moreno MO; Department of Physiology, University of São Paulo, São Paulo, São Paulo, Brazil., Santos GC; Department of Physiology, University of São Paulo, São Paulo, São Paulo, Brazil., Muxel SM; Department of Physiology, University of São Paulo, São Paulo, São Paulo, Brazil., Dos Santos-Silva D; Department of Physiology, University of São Paulo, São Paulo, São Paulo, Brazil., Quiles CL; Department of Physiology, University of São Paulo, São Paulo, São Paulo, Brazil., Sousa KDS; Department of Physiology, University of São Paulo, São Paulo, São Paulo, Brazil., Markus RP; Department of Physiology, University of São Paulo, São Paulo, São Paulo, Brazil., Fernandes PACM; Department of Physiology, University of São Paulo, São Paulo, São Paulo, Brazil.
المصدر: Journal of pineal research [J Pineal Res] 2024 Jan; Vol. 76 (1), pp. e12923. Date of Electronic Publication: 2023 Nov 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 8504412 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-079X (Electronic) Linking ISSN: 07423098 NLM ISO Abbreviation: J Pineal Res Subsets: MEDLINE
أسماء مطبوعة: Publication: : Oxford : Wiley
Original Publication: New York : Liss, c1984-
مواضيع طبية MeSH: Pineal Gland*/metabolism , Melatonin*/pharmacology, Rats ; Animals ; NF-kappa B/metabolism ; Interleukin-10/metabolism ; Signal Transduction
مستخلص: Immune-pineal axis activation is part of the assembly of immune responses. Proinflammatory cytokines inhibit the pineal synthesis of melatonin while inducing it in macrophages by mechanisms dependent on nuclear factor-κB (NF-κB) activation. Cytokines activating the Janus kinase/signal transducer and activator of transcription (STAT) pathways, such as interferon-gamma (IFN-γ) and interleukin-10 (IL-10), modulate melatonin synthesis in the pineal, bone marrow (BM), and spleen. The stimulatory effect of IFN-γ upon the pineal gland depends on STAT1/NF-κB interaction, but the mechanisms controlling IL-10 effects on melatonin synthesis remain unclear. Here, we evaluated the role of STAT3 and NF-κB activation by IL-10 upon the melatonin synthesis of rats' pineal gland, BM, spleen, and peritoneal cells. The results show that IL-10-induced interaction of (p)STAT3 with specific NF-κB dimmers leads to different cell effects. IL-10 increases the pineal's acetylserotonin O-methyltransferase (ASMT), N-acetylserotonin, and melatonin content via nuclear translocation of NF-κB/STAT3. In BM, the nuclear translocation of STAT3/p65-NF-κB complexes increases ASMT expression and melatonin content. Increased pSTAT3/p65-NF-κB nuclear translocation in the spleen enhances phosphorylated serotonin N-acetyltransferase ((p)SNAT) expression and melatonin content. Conversely, in peritoneal cells, IL-10 leads to NF-κB p50/p50 inhibitory dimmer nuclear translocation, decreasing (p)SNAT expression and melatonin content. In conclusion, IL-10's effects on melatonin production depend on the NF-κB subunits interacting with (p)STAT3. Thus, variations of IL-10 levels and downstream pathways during immune responses might be critical regulatory factors adjusting pineal and extra-pineal synthesis of melatonin.
(© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
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معلومات مُعتمدة: 2010/52687-1 Fundação de Amparo à Pesquisa do Estado de São Paulo; 2012/23122-1 Fundação de Amparo à Pesquisa do Estado de São Paulo; 2013/13691-1 Fundação de Amparo à Pesquisa do Estado de São Paulo; 3778555/2013-8 Conselho Nacional de Pesquisa, Tecnologia e Inovação; 304637/2013-0 Conselho Nacional de Pesquisa, Tecnologia e Inovação; 480097/2013-5 Conselho Nacional de Pesquisa, Tecnologia e Inovação
فهرسة مساهمة: Keywords: (p)STAT3; IL-10; NF-κB; bone marrow; immune-pineal axis; spleen and peritoneal cells
المشرفين على المادة: 0 (NF-kappa B)
JL5DK93RCL (Melatonin)
130068-27-8 (Interleukin-10)
تواريخ الأحداث: Date Created: 20231122 Date Completed: 20240122 Latest Revision: 20240122
رمز التحديث: 20240122
DOI: 10.1111/jpi.12923
PMID: 37990784
قاعدة البيانات: MEDLINE
الوصف
تدمد:1600-079X
DOI:10.1111/jpi.12923