دورية أكاديمية
أعرض في EDS

TTC7B is a new prognostic biomarker in head and neck squamous cell carcinoma linked to immune infiltration and ferroptosis.

التفاصيل البيبلوغرافية
العنوان: TTC7B is a new prognostic biomarker in head and neck squamous cell carcinoma linked to immune infiltration and ferroptosis.
المؤلفون: He R; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, China., Zhang X; Guangyuan Hospital of Traditional Chinese Medicine, Guangyuan, China., Wu Y; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, China., Weng Z; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, China., Li L; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
المصدر: Cancer medicine [Cancer Med] 2023 Dec; Vol. 12 (24), pp. 22354-22369. Date of Electronic Publication: 2023 Nov 22.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons Ltd Country of Publication: United States NLM ID: 101595310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-7634 (Electronic) Linking ISSN: 20457634 NLM ISO Abbreviation: Cancer Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Malden, MA] : John Wiley & Sons Ltd., c2012-
مواضيع طبية MeSH: Ferroptosis*/genetics , Head and Neck Neoplasms*/genetics , Squamous Cell Carcinoma of Head and Neck*/genetics, Humans ; Biomarkers ; Prognosis ; Tetratricopeptide Repeat
مستخلص: Objective: To investigate the expression of TTC7B and its prognostic significance, biological roles, and impact on the immune system in patients with head and neck squamous cell carcinoma (HNSCC).
Materials and Methods: Clinical and genomic data were obtained from TCGA (The Cancer Genome Atlas), GEO (Gene Expression Omnibus), GEPIA2 (Gene Expression Profiling Interactive Analysis 2.0), and TIMER2.0 (Tumor Immune Estimation Resource 2.0) databases. R software was utilized to process the retrieved data. qPCR and immunohistochemical assays were performed to validate the findings obtained from the databases.
Results: High expression of TTC7B was observed in HNSCC, and this heightened expression is significantly associated with reduced overall survival (OS) in patients, making it an independent risk factor impacting OS. TTC7B is correlated with focal adhesions and cell migration pathways based on functional enrichment analysis. CIBERSORT analysis and TIMER2.0 show a positive link between TTC7B and multiple immune cells, particularly macrophages. Pearson's analysis reveals a significant correlation between TTC7B and ferroptosis-related genes.
Conclusion: In all, TTC7B could serve as a promising prognostic indicator of HNSCC, and is closely associated with focal adhesions, immune infiltration, and ferroptosis.
(© 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)
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معلومات مُعتمدة: 82141130 National Natural Science Foundation of China
فهرسة مساهمة: Keywords: TTC7B; ferroptosis; focal adhesions; head and neck squamous cell carcinoma; immune infiltration
المشرفين على المادة: 0 (Biomarkers)
تواريخ الأحداث: Date Created: 20231122 Date Completed: 20240116 Latest Revision: 20240123
رمز التحديث: 20240124
مُعرف محوري في PubMed: PMC10757123
DOI: 10.1002/cam4.6715
PMID: 37990988
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-7634
DOI:10.1002/cam4.6715