دورية أكاديمية
REC protein family expansion by the emergence of a new signaling pathway.
| العنوان: | REC protein family expansion by the emergence of a new signaling pathway. |
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| المؤلفون: | Garber ME; Department of Comparative Biochemistry, University of California, Berkeley, California, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA., Frank V; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA., Kazakov AE; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA., Incha MR; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.; Department of Plant and Microbial Biology, University of California, Berkeley, California, USA., Nava AA; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.; Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California, USA., Zhang H; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.; Department of Bioengineering, University of California, Berkeley, California, USA., Valencia LE; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.; Department of Bioengineering, University of California, Berkeley, California, USA., Keasling JD; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.; Department of Plant and Microbial Biology, University of California, Berkeley, California, USA.; Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California, USA.; Department of Bioengineering, University of California, Berkeley, California, USA.; Center for Biosustainability, Danish Technical University, Lyngby, Denmark.; Center for Synthetic Biochemistry, Shenzhen Institutes for Advanced Technologies, Shenzhen, China., Rajeev L; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA., Mukhopadhyay A; Department of Comparative Biochemistry, University of California, Berkeley, California, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA. |
| المصدر: | MBio [mBio] 2023 Dec 19; Vol. 14 (6), pp. e0262223. Date of Electronic Publication: 2023 Nov 22. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, D.C. : American Society for Microbiology |
| مواضيع طبية MeSH: | Bacterial Proteins*/genetics , Bacterial Proteins*/metabolism , Signal Transduction*, Machine Learning ; Evolution, Molecular ; Gene Expression Regulation, Bacterial ; Protein Domains |
| مستخلص: | Importance: We explore when and why large classes of proteins expand into new sequence space. We used an unsupervised machine learning approach to observe the sequence landscape of REC domains of bacterial response regulator proteins. We find that within-gene recombination can switch effector domains and, consequently, change the regulatory context of the duplicated protein. Competing Interests: J.D.K. has financial interests in Amyris, Lygos, Demetrix, Napigen, and Maple Bio. |
| معلومات مُعتمدة: | 2018253421 U.S. Department of Energy (DOE); 2018253421 National Science Foundation (NSF) |
| فهرسة مساهمة: | Keywords: domain swapping; evolution; gene regulation; genetic recombination; large protein families; response regulator; signal transduction; two-component regulatory systems |
| المشرفين على المادة: | 0 (Bacterial Proteins) |
| تواريخ الأحداث: | Date Created: 20231122 Date Completed: 20240728 Latest Revision: 20240728 |
| رمز التحديث: | 20240728 |
| مُعرف محوري في PubMed: | PMC10746176 |
| DOI: | 10.1128/mbio.02622-23 |
| PMID: | 37991384 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2150-7511 |
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| DOI: | 10.1128/mbio.02622-23 |