دورية أكاديمية
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Gut microbiomes of cycad-feeding insects tolerant to β-methylamino-L-alanine (BMAA) are rich in siderophore biosynthesis.

التفاصيل البيبلوغرافية
العنوان: Gut microbiomes of cycad-feeding insects tolerant to β-methylamino-L-alanine (BMAA) are rich in siderophore biosynthesis.
المؤلفون: Gutiérrez-García K; Evolution of Metabolic Diversity Laboratory, Unidad de Genómica Avanzada (Langebio), Cinvestav-IPN, Km 9.6 Libramiento Irapuato - León, Irapuato, Guanajuato, 36824, México.; Department of Embryology, Carnegie Institution for Science, 3520 San Martin Drive, Baltimore, MD, 21218, USA., Whitaker MRL; Museum of Comparative Zoology, Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA, 02138, USA. melliwhitaker@gmail.com.; Department of Biological Sciences, East Tennessee State University, Johnson City, TN, 37614, USA. melliwhitaker@gmail.com., Bustos-Díaz ED; Evolution of Metabolic Diversity Laboratory, Unidad de Genómica Avanzada (Langebio), Cinvestav-IPN, Km 9.6 Libramiento Irapuato - León, Irapuato, Guanajuato, 36824, México.; Institute of Biology, Leiden University, Sylviusweg 72, Leiden, 2333 BE, The Netherlands., Salzman S; Museum of Comparative Zoology, Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA, 02138, USA.; University of Georgia, Entomology Department, Athens, GA, 30602, USA., Ramos-Aboites HE; Evolution of Metabolic Diversity Laboratory, Unidad de Genómica Avanzada (Langebio), Cinvestav-IPN, Km 9.6 Libramiento Irapuato - León, Irapuato, Guanajuato, 36824, México., Reitz ZL; Bioinformatics Group, Wageningen University, Droevendaalsesteeg 1, 6708PB, Wageningen, The Netherlands., Pierce NE; Museum of Comparative Zoology, Department of Organismic and Evolutionary Biology, Harvard University, 26 Oxford Street, Cambridge, MA, 02138, USA., Cibrián-Jaramillo A; Ecological and Evolutionary Genomics Laboratory, Unidad de Genómica Avanzada (Langebio), Cinvestav-IPN, Km 9.6 Libramiento Irapuato - León, Irapuato, Guanajuato, 36824, México.; Naturalis Biodiversity Center, Darwinweg 2, 2333 CR, Leiden, The Netherlands., Barona-Gómez F; Evolution of Metabolic Diversity Laboratory, Unidad de Genómica Avanzada (Langebio), Cinvestav-IPN, Km 9.6 Libramiento Irapuato - León, Irapuato, Guanajuato, 36824, México. f.barona.gomez@biology.leidenuniv.nl.; Institute of Biology, Leiden University, Sylviusweg 72, Leiden, 2333 BE, The Netherlands. f.barona.gomez@biology.leidenuniv.nl.
المصدر: ISME communications [ISME Commun] 2023 Nov 22; Vol. 3 (1), pp. 122. Date of Electronic Publication: 2023 Nov 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 9918205372406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2730-6151 (Electronic) Linking ISSN: 27306151 NLM ISO Abbreviation: ISME Commun Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 3 2024- : Oxford : Oxford University Press
Original Publication: [London] : Springer Nature on behalf of the International Society for Microbial Ecology, [2021]-
مستخلص: Ingestion of the cycad toxins β-methylamino-L-alanine (BMAA) and azoxyglycosides is harmful to diverse organisms. However, some insects are specialized to feed on toxin-rich cycads with apparent immunity. Some cycad-feeding insects possess a common set of gut bacteria, which might play a role in detoxifying cycad toxins. Here, we investigated the composition of gut microbiota from a worldwide sample of cycadivorous insects and characterized the biosynthetic potential of selected bacteria. Cycadivorous insects shared a core gut microbiome consisting of six bacterial taxa, mainly belonging to the Proteobacteria, which we were able to isolate. To further investigate selected taxa from diverging lineages, we performed shotgun metagenomic sequencing of co-cultured bacterial sub-communities. We characterized the biosynthetic potential of four bacteria from Serratia, Pantoea, and two different Stenotrophomonas lineages, and discovered a suite of biosynthetic gene clusters notably rich in siderophores. Siderophore semi-untargeted metabolomics revealed a broad range of chemically related yet diverse iron-chelating metabolites, including desferrioxamine B, suggesting the occurrence of an unprecedented desferrioxamine-like biosynthetic pathway that remains to be identified. These results provide a foundation for future investigations into how cycadivorous insects tolerate diets rich in azoxyglycosides, BMAA, and other cycad toxins, including a possible role for bacterial siderophores.
(© 2023. The Author(s).)
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معلومات مُعتمدة: 1541560, 1309425, 1906333 National Science Foundation (NSF); NAF/R2/180631 Newton Fund; 169701, 179290, 177568, FON.INST./265/2016 285746, Consejo Nacional de Ciencia y Tecnología (National Council of Science and Technology, Mexico)
تواريخ الأحداث: Date Created: 20231122 Latest Revision: 20231125
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10665472
DOI: 10.1038/s43705-023-00323-8
PMID: 37993724
قاعدة البيانات: MEDLINE
الوصف
تدمد:2730-6151
DOI:10.1038/s43705-023-00323-8