دورية أكاديمية
Preoperative versus postoperative misoprostol use for prevention of blood loss during caesarean section in pregnant women at term: a multi-centre randomised controlled trial.
| العنوان: | Preoperative versus postoperative misoprostol use for prevention of blood loss during caesarean section in pregnant women at term: a multi-centre randomised controlled trial. |
|---|---|
| المؤلفون: | Ajah LO; Institute of Maternal and Child Health, Ituku-Ozalla Campus, University of Nigeria, Enugu, Nigeria.; Department of Obstetrics and Gynaecology, Faculty of Medical Sciences, University of Nigeria, Enugu, Nigeria., Ajah MI; Institute of Maternal and Child Health, Ituku-Ozalla Campus, University of Nigeria, Enugu, Nigeria., Ezegwui HU; Institute of Maternal and Child Health, Ituku-Ozalla Campus, University of Nigeria, Enugu, Nigeria.; Department of Obstetrics and Gynaecology, Faculty of Medical Sciences, University of Nigeria, Enugu, Nigeria., Nwankwo TO; Institute of Maternal and Child Health, Ituku-Ozalla Campus, University of Nigeria, Enugu, Nigeria.; Department of Obstetrics and Gynaecology, Faculty of Medical Sciences, University of Nigeria, Enugu, Nigeria., Iyoke CA; Institute of Maternal and Child Health, Ituku-Ozalla Campus, University of Nigeria, Enugu, Nigeria.; Department of Obstetrics and Gynaecology, Faculty of Medical Sciences, University of Nigeria, Enugu, Nigeria., Nwigboji WN; Department of Obstetrics and Gynaecology, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Nigeria. |
| المصدر: | The Journal of international medical research [J Int Med Res] 2023 Nov; Vol. 51 (11), pp. 3000605231213242. |
| نوع المنشور: | Randomized Controlled Trial; Multicenter Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Publications Country of Publication: England NLM ID: 0346411 Publication Model: Print Cited Medium: Internet ISSN: 1473-2300 (Electronic) Linking ISSN: 03000605 NLM ISO Abbreviation: J Int Med Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Nov. 2012- : London : Sage Publications Original Publication: Northampton, Eng., Cambridge Medical Publications ltd. |
| مواضيع طبية MeSH: | Misoprostol*/therapeutic use , Misoprostol*/adverse effects , Oxytocics*/therapeutic use, Female ; Humans ; Pregnancy ; Cesarean Section/adverse effects ; Pregnant Women ; Oxytocin/adverse effects |
| مستخلص: | Objective: Caesarean section is associated with higher blood loss than vaginal delivery. This study was performed to compare the safety and efficacy of preoperative versus postoperative rectal and sublingual misoprostol use for prevention of blood loss in women undergoing elective caesarean delivery. Methods: Eligible patients in Southeast Nigeria were randomly classified into those that received 600 µg of preoperative rectal, postoperative rectal, preoperative sublingual, and postoperative sublingual misoprostol. All patients received 10 units of intravenous oxytocin immediately after delivery. Data were analysed with SPSS Version 23. Results: Preoperative sublingual misoprostol use caused the highest postoperative packed cell volume, least change in the packed cell volume, and lowest intraoperative blood loss. Preoperative sublingual and rectal misoprostol use was associated with better haematological indices and maternal outcomes than postoperative use by these routes. However, preoperative sublingual and rectal use caused more maternal side effects than postoperative use by these routes. Conclusion: Preoperative sublingual misoprostol was associated with the most favourable haematological indices. Although preoperative sublingual and rectal misoprostol use caused more maternal side effects, these routes were associated with better haematological indices and maternal outcomes than postoperative sublingual and rectal misoprostol use. Competing Interests: Declaration of conflicting interestsThe authors have no conflicts of interest. |
| References: | Int J Gynaecol Obstet. 2015 Dec;131(3):265-8. (PMID: 26341174) Int J Gynaecol Obstet. 2019 Jan;144(1):122-127. (PMID: 30387124) Hum Reprod. 2002 Feb;17(2):332-6. (PMID: 11821273) J Thorac Dis. 2009 Dec;1(1):51-4. (PMID: 22263004) Int J Gynaecol Obstet. 2016 Feb;132(2):184-7. (PMID: 26534874) Int J Gynaecol Obstet. 2019 Oct;147(1):102-107. (PMID: 31304593) Arch Gynecol Obstet. 2018 Dec;298(6):1115-1122. (PMID: 30291483) BMJ Glob Health. 2021 Jun;6(6):. (PMID: 34130991) Am J Obstet Gynecol. 2011 Sep;205(3):262.e1-8. (PMID: 22071057) Int J Gynaecol Obstet. 2007 Dec;99 Suppl 2:S160-7. (PMID: 17963768) Int J Gynaecol Obstet. 2016 Jan;132(1):82-4. (PMID: 26522140) Obstet Gynecol. 2006 Sep;108(3 Pt 1):582-90. (PMID: 16946218) Perspect Clin Res. 2012 Jul;3(3):102-8. (PMID: 23125961) |
| فهرسة مساهمة: | Keywords: Caesarean section; Nigeria; blood loss; postoperative; preoperative; rectal misoprostol; sublingual misoprostol |
| المشرفين على المادة: | 0E43V0BB57 (Misoprostol) 0 (Oxytocics) 50-56-6 (Oxytocin) |
| تواريخ الأحداث: | Date Created: 20231123 Date Completed: 20231127 Latest Revision: 20231127 |
| رمز التحديث: | 20231128 |
| مُعرف محوري في PubMed: | PMC10666823 |
| DOI: | 10.1177/03000605231213242 |
| PMID: | 37994048 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1473-2300 |
|---|---|
| DOI: | 10.1177/03000605231213242 |