دورية أكاديمية
أعرض في EDS

Therapeutic Targeting of Krüppel-Like Factor 4 and Its Pharmacological Potential in Parkinson's Disease: a Comprehensive Review.

التفاصيل البيبلوغرافية
العنوان: Therapeutic Targeting of Krüppel-Like Factor 4 and Its Pharmacological Potential in Parkinson's Disease: a Comprehensive Review.
المؤلفون: Zamanian MY; Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, 6718773654, Iran.; Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, 6718773654, Iran., Golmohammadi M; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 1988873554, Iran., Amin RS; Sharif Medical & Dental College, Lahore, Pakistan., Bustani GS; College of Dentistry, The Islamic University, Najaf, Iraq., Romero-Parra RM; General Studies, Universidad Continental, Lima, Perú., Zabibah RS; Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq., Oz T; Department of Toxicology, Poznan University of Medical Sciences, Rokietnicka 3, 60-806, Poznan, Poland., Jalil AT; Medical Laboratories Techniques Department, Al-Mustaqbal University College, Babylon, Hilla, 51001, Iraq., Soltani A; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 1988873554, Iran. afsanehstn74@gmail.com., Kujawska M; Department of Toxicology, Poznan University of Medical Sciences, Rokietnicka 3, 60-806, Poznan, Poland. kujawska@ump.edu.pl.
المصدر: Molecular neurobiology [Mol Neurobiol] 2024 Jun; Vol. 61 (6), pp. 3596-3606. Date of Electronic Publication: 2023 Nov 24.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Clifton, NJ : Humana Press, c1987-
مواضيع طبية MeSH: Kruppel-Like Factor 4* , Parkinson Disease*/metabolism , Parkinson Disease*/drug therapy , Parkinson Disease*/pathology , Kruppel-Like Transcription Factors*/metabolism, Humans ; Animals ; Oxidative Stress/drug effects ; Molecular Targeted Therapy ; Apoptosis/drug effects
مستخلص: Krüppel-like factor 4 (KLF4), a zinc finger transcription factor, is found in different human tissues and shows diverse regulatory activities in a cell-dependent manner. In the brain, KLF4 controls various neurophysiological and neuropathological processes, and its contribution to various neurological diseases has been widely reported. Parkinson's disease (PD) is an age-related neurodegenerative disease that might have a connection with KLF4. In this review, we discussed the potential implication of KLF4 in fundamental molecular mechanisms of PD, including aberrant proteostasis, neuroinflammation, apoptosis, oxidative stress, and iron overload. The evidence collected herein sheds new light on KLF4-mediated pathways, which manipulation appears to be a promising therapeutic target for PD management. However, there is a gap in the knowledge on this topic, and extended research is required to understand the translational value of the KLF4-oriented therapeutical approach in PD.
(© 2023. The Author(s).)
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فهرسة مساهمة: Keywords: Apoptosis; Autophagy; KLF4; Neuroinflammation; Oxidative stress; Parkinson’s disease
المشرفين على المادة: 0 (Kruppel-Like Factor 4)
0 (Kruppel-Like Transcription Factors)
0 (KLF4 protein, human)
تواريخ الأحداث: Date Created: 20231123 Date Completed: 20240510 Latest Revision: 20240710
رمز التحديث: 20240711
مُعرف محوري في PubMed: PMC11087351
DOI: 10.1007/s12035-023-03800-2
PMID: 37996730
قاعدة البيانات: MEDLINE
الوصف
تدمد:1559-1182
DOI:10.1007/s12035-023-03800-2