دورية أكاديمية

Geographical classification of opium samples from Myanmar and Afghanistan by NMR profiling and chemometrics.

التفاصيل البيبلوغرافية
العنوان: Geographical classification of opium samples from Myanmar and Afghanistan by NMR profiling and chemometrics.
المؤلفون: Liu CM; Key Laboratory of Drug Monitoring and Control, Drug Intelligence and Forensic Center of Ministry of Public Security, Beijing, China., Jia W; Key Laboratory of Drug Monitoring and Control, Drug Intelligence and Forensic Center of Ministry of Public Security, Beijing, China., Liu XY; School of pharmacy, China Pharmaceutical University, Nanjing, China., Du Y; School of pharmacy, China Pharmaceutical University, Nanjing, China., Hua ZD; Key Laboratory of Drug Monitoring and Control, Drug Intelligence and Forensic Center of Ministry of Public Security, Beijing, China.
المصدر: Drug testing and analysis [Drug Test Anal] 2024 Aug; Vol. 16 (8), pp. 879-885. Date of Electronic Publication: 2023 Nov 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: England NLM ID: 101483449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-7611 (Electronic) Linking ISSN: 19427603 NLM ISO Abbreviation: Drug Test Anal Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Chichester, UK : John Wiley & Sons
مواضيع طبية MeSH: Opium*/analysis , Opium*/chemistry, Afghanistan ; Myanmar ; Discriminant Analysis ; Magnetic Resonance Spectroscopy/methods ; Least-Squares Analysis ; Proton Magnetic Resonance Spectroscopy/methods
مستخلص: This study presents a new strategy to discriminate between opium samples obtained from different geographical regions. Nuclear magnetic resonance (NMR) profiling and chemometrics were applied to geographical classification of opium originating from Myanmar and Afghanistan, which are two major opium producing countries in the world. A total of 50 Myanmar and 46 Afghanistan authentic opium samples were analyzed by 1 H-NMR, and the chemical profiles were characterized. Different sample preparation procedures, data processing methods, and chemometrics were compared to obtain the best classification effect. It was found that drying and the addition of buffer solutions were unnecessary for classification purposes; thus, the gum opium samples were extracted directly with CD 3 OD, which shortened sample preparation time. A full discrimination between the two geographical origins was achieved by 1 H-NMR profiling and orthogonal partial least squares discriminant analysis. All 30 opium samples were classified correctly by the developed orthogonal partial least squares discriminant analysis model. Compared with traditional chromatography and mass spectrometry profiling methods, the 1 H-NMR profiling method was faster (with instrument analysis time of less than 3 min) and reproducible. This study provides new insights into the applying of NMR profiling and chemometrics to rapid drug profiling analysis.
(© 2023 John Wiley & Sons, Ltd.)
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معلومات مُعتمدة: 2022YFC3300902 National Key Research and Development Program of China; 2021JC23 Project
فهرسة مساهمة: Keywords: NMR profiling; classification; geographical origin; opium; orthogonal partial least squares discriminant analysis (OPLS‐DA)
المشرفين على المادة: 8008-60-4 (Opium)
تواريخ الأحداث: Date Created: 20231124 Date Completed: 20240812 Latest Revision: 20240812
رمز التحديث: 20240813
DOI: 10.1002/dta.3613
PMID: 37997567
قاعدة البيانات: MEDLINE
الوصف
تدمد:1942-7611
DOI:10.1002/dta.3613