دورية أكاديمية
أعرض في EDS

Sterilized Polyhexanide-Releasing Chitosan Membranes with Potential for Use in Antimicrobial Wound Dressings.

التفاصيل البيبلوغرافية
العنوان: Sterilized Polyhexanide-Releasing Chitosan Membranes with Potential for Use in Antimicrobial Wound Dressings.
المؤلفون: Vaz LM; Chemical Process Engineering and Forest Products Research Centre, Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456 Coimbra, Portugal., Branco R; Centre for Mechanical Engineering, Materials and Processes, Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456 Coimbra, Portugal., Morais PV; Centre for Mechanical Engineering, Materials and Processes, Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456 Coimbra, Portugal., Guiomar AJ; Chemical Process Engineering and Forest Products Research Centre, Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456 Coimbra, Portugal.
المصدر: Membranes [Membranes (Basel)] 2023 Nov 08; Vol. 13 (11). Date of Electronic Publication: 2023 Nov 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101577807 Publication Model: Electronic Cited Medium: Print ISSN: 2077-0375 (Print) Linking ISSN: 20770375 NLM ISO Abbreviation: Membranes (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مستخلص: Wound infection is a common complication of chronic wounds. It can impair healing, which may not occur without external help. Antimicrobial dressings (AMDs) are a type of external help to infected chronic wounds. In this study, highly porous membranes made of only chitosan and containing the antiseptic polyhexanide (poly(hexamethylene biguanide); PHMB) were prepared by cryogelation, aiming to be used in AMDs. These membranes exhibited a water swelling capacity of 748%, a water drop penetration time of 11 s in a dry membrane and a water vapor transmission rate of 34,400 g H 2 O/m 2 /24 h when in contact with water. The best drug loading method involved simultaneous loading by soaking in a PHMB solution and sterilization by autoclaving, resulting in sterilized, drug-loaded membranes. When these membranes and a commercial PHMB-releasing AMD were assayed under the same conditions, albeit far from the in vivo conditions, their drug release kinetics were comparable, releasing PHMB for ca. 6 and 4 h, respectively. These membranes exhibited high antibacterial activity against Escherichia coli , Staphylococcus aureus and Pseudomonas aeruginosa , which are bacterial species commonly found in infected wounds and blood clotting activity. The obtained results suggest that these membranes may have potential for use in the development of AMDs.
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معلومات مُعتمدة: PTDC/CTMBIO73640/2014 Fundação para a Ciência e Tecnologia; ERA-MIN 2 REVIVING ERA-MIN-2019_67 Fundação para a Ciência e Tecnologia; UIDB/00102/2020 Fundação para a Ciência e Tecnologia; UIDP/00102/2020 Fundação para a Ciência e Tecnologia; UIDB/00285/2020 Fundação para a Ciência e Tecnologia; UIDB/04564/2020 Fundação para a Ciência e Tecnologia; BIORECOVER (grant agreement no. 821096) European Union's Horizon 2020 research and innovation programme
فهرسة مساهمة: Keywords: PHMB; antimicrobial; chitosan; controlled drug release; drug delivery; membrane; poly(hexamethylene biguanide); polyhexamethylene biguanide; polyhexanide; wound dressing
تواريخ الأحداث: Date Created: 20231124 Latest Revision: 20231127
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10673555
DOI: 10.3390/membranes13110877
PMID: 37999363
قاعدة البيانات: MEDLINE
الوصف
تدمد:2077-0375
DOI:10.3390/membranes13110877