دورية أكاديمية
Association between first-week propofol administration and long-term outcomes of critically ill mechanically ventilated patients: A retrospective cohort study.
| العنوان: | Association between first-week propofol administration and long-term outcomes of critically ill mechanically ventilated patients: A retrospective cohort study. |
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| المؤلفون: | Slingerland-Boot R; Department of Intensive Care Medicine, Gelderse Vallei Hospital, Ede, the Netherlands; Wageningen University & Research, Division of Human Nutrition and Health, Wageningen, the Netherlands., Kummerow M; Department of Intensive Care Medicine, Gelderse Vallei Hospital, Ede, the Netherlands., Arbous SM; Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, the Netherlands., van Zanten ARH; Department of Intensive Care Medicine, Gelderse Vallei Hospital, Ede, the Netherlands; Wageningen University & Research, Division of Human Nutrition and Health, Wageningen, the Netherlands. Electronic address: zantena@zgv.nl. |
| المصدر: | Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2024 Jan; Vol. 43 (1), pp. 42-51. Date of Electronic Publication: 2023 Nov 07. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 8309603 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1983 (Electronic) Linking ISSN: 02615614 NLM ISO Abbreviation: Clin Nutr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2004->: Kidlington, Oxford, U.K. : Elsevier Original Publication: Edinburgh ; New York : Churchill Livingstone, c1982- |
| مواضيع طبية MeSH: | Propofol*/adverse effects, Adult ; Humans ; Critical Illness/therapy ; Respiration, Artificial ; Cohort Studies ; Retrospective Studies ; Intensive Care Units |
| مستخلص: | Background & Aim: Propofol is commonly used in ICUs, but its long-term effects have not been thoroughly studied. In vitro studies suggest it may harm mitochondrial function, potentially affecting clinical outcomes. This study aimed to investigate the association between substantial propofol sedation and clinical outcomes in critically ill patients. Methods: We conducted a single-centre cohort study of critically ill, mechanically ventilated (≥7 days) adults to compare patients who received a substantial dose of propofol (cumulative >500 mg) during the first week of ICU admission with those who did not. The primary outcome was the association between substantial propofol administration and 6-month mortality, adjusted for relevant covariates. Subanalyses were performed for administration in the early (day 1-3) and late (day 4-7) acute phases of critical illness due to the metabolic changes in this period. Secondary outcomes included tracheostomy need and duration, length of ICU and hospital stay (LOS), discharge destinations, ICU, hospital, and 3-month mortality. Results: A total of 839 patients were enrolled, with 73.7 % receiving substantial propofol administration (substantial propofol dose group). Six-month all-cause mortality was 32.4 %. After adjusting for relevant variables, we found no statistically significant difference in 6-month mortality between both groups. There were also no significant differences in secondary outcomes. Conclusion: Our study suggests that substantial propofol administration during the first week of ICU stay in the least sick critically ill, mechanically ventilated adult patients is safe, with no significant associations found with 6-month mortality, ICU or hospital LOS, differences in discharge destinations or need for tracheostomy. Competing Interests: Conflict of interest Professor Van Zanten reported receiving honoraria for advisory board meetings, lectures, research, and travel expenses from Abbott, AoP Pharma, Baxter, Cardinal Health, Danone-Nutricia, Dim-3, Fresenius Kabi, GE Healthcare, Medcaptain, Mermaid, Nestle-Novartis, PAION, Lyric, and Rousselot. The other authors have nothing to declare. (Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: 6-Month mortality; Clinical outcomes; Mechanical ventilation; Mitochondrial function; Propofol; Sedation |
| المشرفين على المادة: | YI7VU623SF (Propofol) |
| تواريخ الأحداث: | Date Created: 20231124 Date Completed: 20231226 Latest Revision: 20240415 |
| رمز التحديث: | 20240416 |
| DOI: | 10.1016/j.clnu.2023.10.029 |
| PMID: | 38000194 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1532-1983 |
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| DOI: | 10.1016/j.clnu.2023.10.029 |