دورية أكاديمية
Dosimetric comparison of magnetic resonance-guided radiation therapy, intensity-modulated proton therapy and volumetric-modulated arc therapy for distal esophageal cancer.
| العنوان: | Dosimetric comparison of magnetic resonance-guided radiation therapy, intensity-modulated proton therapy and volumetric-modulated arc therapy for distal esophageal cancer. |
|---|---|
| المؤلفون: | Barsky AR; Department of Radiation Oncology, Lynn Cancer Institute, Baptist Health South Florida, Boca Raton, FL 33486, USA. Electronic address: Andrew.Barsky@baptisthealth.net., George J; Department of Radiation Oncology, Orlando Health Cancer Institute, Orlando, FL 32806, USA., Wroe AJ; Department of Radiation Oncology, Miami Cancer Institute, Miami, FL, 33176, USA., Mittauer KE; Department of Radiation Oncology, Miami Cancer Institute, Miami, FL, 33176, USA., Kaiser A; Department of Radiation Oncology, Miami Cancer Institute, Miami, FL, 33176, USA., Herrera R; Department of Radiation Oncology, Miami Cancer Institute, Miami, FL, 33176, USA., Yu J; Department of Radiation Oncology, Miami Cancer Institute, Miami, FL, 33176, USA., Gutierrez AN; Department of Radiation Oncology, Miami Cancer Institute, Miami, FL, 33176, USA., Alvarez D; Department of Radiation Oncology, Miami Cancer Institute, Miami, FL, 33176, USA., McCulloch J; Department of Radiation Oncology, Miami Cancer Institute, Miami, FL, 33176, USA., Kasper ME; Department of Radiation Oncology, Lynn Cancer Institute, Baptist Health South Florida, Boca Raton, FL 33486, USA., Mehta MP; Department of Radiation Oncology, Miami Cancer Institute, Miami, FL, 33176, USA., Chuong MD; Department of Radiation Oncology, Miami Cancer Institute, Miami, FL, 33176, USA. |
| المصدر: | Medical dosimetry : official journal of the American Association of Medical Dosimetrists [Med Dosim] 2024 Summer; Vol. 49 (2), pp. 121-126. Date of Electronic Publication: 2023 Nov 23. |
| نوع المنشور: | Journal Article; Comparative Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 8908862 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4022 (Electronic) Linking ISSN: 18734022 NLM ISO Abbreviation: Med Dosim Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2000->: New York, NY : Elsevier Science Original Publication: [Southwest Harbor, Me. : Beech Hill Pub., |
| مواضيع طبية MeSH: | Radiotherapy, Intensity-Modulated*/methods , Esophageal Neoplasms*/radiotherapy , Proton Therapy*/methods , Radiotherapy, Image-Guided*/methods , Radiotherapy Dosage*, Humans ; Retrospective Studies ; Radiotherapy Planning, Computer-Assisted/methods ; Magnetic Resonance Imaging ; Organs at Risk |
| مستخلص: | Advances in radiotherapy (RT) technologies permit significant decreases in the dose delivered to organs at risk (OARs) for patients with esophageal cancer (EC). Novel RT modalities such as proton beam therapy (PBT) and magnetic resonance-guided radiotherapy (MRgRT), as well as motion management techniques including breath hold (BH) are expected to further improve the therapeutic ratio. However, to our knowledge, the dosimetric benefits of PBT vs MRgRT vs volumetric-modulated arc therapy (VMAT) have not been directly compared for EC. We performed a retrospective in silico evaluation using the images and datasets of nine distal EC patients who were treated at our institution with a 0.35-Tesla MR linac to 50.4 Gy in 28 fractions in mid-inspiration BH (BH-MRgRT). Comparison free-breathing (FB) intensity-modulated PBT (FB-IMPT) and FB-VMAT plans were retrospectively created using the same prescription dose, target volume coverage goals, and OAR constraints. A 5 mm setup margin was used for all plans. BH-IMPT and BH-VMAT plans were not evaluated as they would not reflect our institutional practice. Planners were blinded to the results of the treatment plans created using different radiation modalities. The primary objective was to compare plan quality, target volume coverage, and OAR doses. All treatment plans met pre-defined target volume coverage and OAR constraints. The median conformity and homogeneity indices between FB-IMPT, BH-MRgRT and FB-VMAT were 1.13, 1.25, and 1.43 (PITV) and 1.04, 1.15, 1.04 (HI), respectively. For FB-IMPT, BH-MRgRT and FB-VMAT the median heart dose metrics were 52.8, 79.3, 146.8 (V Competing Interests: Conflicts of Interest The authors declare no conflicts of interest. (Copyright © 2023 American Association of Medical Dosimetrists. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Dosimetry; Esophageal Cancer; MR-guided radiation Therapy; Proton therapy; Radiation oncology |
| تواريخ الأحداث: | Date Created: 20231124 Date Completed: 20240506 Latest Revision: 20240506 |
| رمز التحديث: | 20240507 |
| DOI: | 10.1016/j.meddos.2023.09.004 |
| PMID: | 38001010 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1873-4022 |
|---|---|
| DOI: | 10.1016/j.meddos.2023.09.004 |