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Genomic Signatures of Positive Selection in Human Populations of the OXT , OXTR , AVP , AVPR1A and AVR1B Gene Variants Related to the Regulation of Psychoemotional Response.

التفاصيل البيبلوغرافية
العنوان: Genomic Signatures of Positive Selection in Human Populations of the OXT , OXTR , AVP , AVPR1A and AVR1B Gene Variants Related to the Regulation of Psychoemotional Response.
المؤلفون: Bakoev SY; Federal State Budgetary Institution 'Centre for Strategic Planning and Management of Biomedical Health Risks' of the Federal Medical Biological Agency (Centre for Strategic Planning of FMBA of Russia), Pogodinskaya Street, 10, Bld. 1, 119121 Moscow, Russia., Korobeinikova AV; Federal State Budgetary Institution 'Centre for Strategic Planning and Management of Biomedical Health Risks' of the Federal Medical Biological Agency (Centre for Strategic Planning of FMBA of Russia), Pogodinskaya Street, 10, Bld. 1, 119121 Moscow, Russia., Mishina AI; Federal State Budgetary Institution 'Centre for Strategic Planning and Management of Biomedical Health Risks' of the Federal Medical Biological Agency (Centre for Strategic Planning of FMBA of Russia), Pogodinskaya Street, 10, Bld. 1, 119121 Moscow, Russia., Kabieva SS; Federal State Budgetary Institution 'Centre for Strategic Planning and Management of Biomedical Health Risks' of the Federal Medical Biological Agency (Centre for Strategic Planning of FMBA of Russia), Pogodinskaya Street, 10, Bld. 1, 119121 Moscow, Russia., Mitrofanov SI; Federal State Budgetary Institution 'Centre for Strategic Planning and Management of Biomedical Health Risks' of the Federal Medical Biological Agency (Centre for Strategic Planning of FMBA of Russia), Pogodinskaya Street, 10, Bld. 1, 119121 Moscow, Russia., Ivashechkin AA; Federal State Budgetary Institution 'Centre for Strategic Planning and Management of Biomedical Health Risks' of the Federal Medical Biological Agency (Centre for Strategic Planning of FMBA of Russia), Pogodinskaya Street, 10, Bld. 1, 119121 Moscow, Russia., Akinshina AI; Federal State Budgetary Institution 'Centre for Strategic Planning and Management of Biomedical Health Risks' of the Federal Medical Biological Agency (Centre for Strategic Planning of FMBA of Russia), Pogodinskaya Street, 10, Bld. 1, 119121 Moscow, Russia., Snigir EA; Federal State Budgetary Institution 'Centre for Strategic Planning and Management of Biomedical Health Risks' of the Federal Medical Biological Agency (Centre for Strategic Planning of FMBA of Russia), Pogodinskaya Street, 10, Bld. 1, 119121 Moscow, Russia., Yudin SM; Federal State Budgetary Institution 'Centre for Strategic Planning and Management of Biomedical Health Risks' of the Federal Medical Biological Agency (Centre for Strategic Planning of FMBA of Russia), Pogodinskaya Street, 10, Bld. 1, 119121 Moscow, Russia., Yudin VS; Federal State Budgetary Institution 'Centre for Strategic Planning and Management of Biomedical Health Risks' of the Federal Medical Biological Agency (Centre for Strategic Planning of FMBA of Russia), Pogodinskaya Street, 10, Bld. 1, 119121 Moscow, Russia., Getmantseva LV; Federal State Budgetary Institution 'Centre for Strategic Planning and Management of Biomedical Health Risks' of the Federal Medical Biological Agency (Centre for Strategic Planning of FMBA of Russia), Pogodinskaya Street, 10, Bld. 1, 119121 Moscow, Russia., Anderzhanova EA; Federal State Budgetary Institution 'Centre for Strategic Planning and Management of Biomedical Health Risks' of the Federal Medical Biological Agency (Centre for Strategic Planning of FMBA of Russia), Pogodinskaya Street, 10, Bld. 1, 119121 Moscow, Russia.
المصدر: Genes [Genes (Basel)] 2023 Nov 08; Vol. 14 (11). Date of Electronic Publication: 2023 Nov 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مواضيع طبية MeSH: Oxytocin*/genetics , Vasopressins*, Humans ; Genomics ; Receptors, Oxytocin/genetics ; Receptors, Vasopressin/genetics
مستخلص: The neurobiological systems of maintenance and control of behavioral responses result from natural selection. We have analyzed the selection signatures for single nucleotide variants (SNV) of the genes of oxytocin ( OXT , OXTR ) and vasopressin ( AVP , AVPR1A , AVPR1B ) systems, which are associated with the regulation of social and emotional behavior in distinct populations. The analysis was performed using original WGS (whole genome sequencing) data on Eastern Slavs (SlEast), as well as publicly available data from the 1000 Genomes Project on GBR, FIN, IBR, PUR, BEB, CHB, and ACB populations (the latter were taken as reference). To identify selection signatures, we rated the integrated haplotype scores (iHS), the numbers of segregating sites by length (nSl), and the integrated haplotype homozygosity pooled (iHH12) measures; the fixation index Fst was implemented to assess genetic differentiation between populations. We revealed that the strongest genetic differentiation of populations was found with respect to the AVPR1B gene, with the greatest differentiation observed in GRB (Fst = 0.316) and CHB (Fst = 0.325) in comparison to ACB. Also, high Fst values were found for SNVs of the AVPR1B gene rs28499431, rs33940624, rs28477649, rs3883899, and rs28452187 in most of the populations. Selection signatures have also been identified in the AVP , AVPR1A , OXT , and OXTR genes. Our analysis shows that the OXT , OXTR , AVP , AVPR1A , and AVPR1B genes were subject to positive selection in a population-specific process, which was likely contributing to the diversity of adaptive emotional response types and social function realizations.
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فهرسة مساهمة: Keywords: AVP; AVPR1A; AVPR1B; OXT; OXTR; adaptation; genomic signatures; positive selection; stress
المشرفين على المادة: 50-56-6 (Oxytocin)
11000-17-2 (Vasopressins)
0 (OXTR protein, human)
0 (Receptors, Oxytocin)
0 (AVPR1A protein, human)
0 (Receptors, Vasopressin)
تواريخ الأحداث: Date Created: 20231125 Date Completed: 20231127 Latest Revision: 20240620
رمز التحديث: 20240621
مُعرف محوري في PubMed: PMC10670988
DOI: 10.3390/genes14112053
PMID: 38002996
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4425
DOI:10.3390/genes14112053