دورية أكاديمية
Quassinoids from Twigs of Harrisonia perforata (Blanco) Merr and Their Anti-Parkinson's Disease Effect.
العنوان: | Quassinoids from Twigs of Harrisonia perforata (Blanco) Merr and Their Anti-Parkinson's Disease Effect. |
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المؤلفون: | Cai M; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; School of Life Sciences, Yunnan University, Kunming 650091, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Bai XL; University of Chinese Academy of Sciences, Beijing 100049, China.; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China., Zang HJ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; School of Life Sciences, Yunnan University, Kunming 650091, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Tang XH; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; School of Life Sciences, Yunnan University, Kunming 650091, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Yan Y; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; State Key Laboratory of Functions and Applications of Medicinal Plants & College of Pharmacy, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang 550014, China., Wan JJ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Peng MY; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; State Key Laboratory of Functions and Applications of Medicinal Plants & College of Pharmacy, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang 550014, China., Liang H; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Liu L; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Guo F; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Zhao PJ; School of Life Sciences, Yunnan University, Kunming 650091, China., Liao X; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China., Di YT; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China., Hao XJ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.; State Key Laboratory of Functions and Applications of Medicinal Plants & College of Pharmacy, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang 550014, China. |
المصدر: | International journal of molecular sciences [Int J Mol Sci] 2023 Nov 11; Vol. 24 (22). Date of Electronic Publication: 2023 Nov 11. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2000- |
مواضيع طبية MeSH: | Parkinson Disease*/drug therapy , Quassins* , Simaroubaceae*/chemistry, Plant Extracts/pharmacology ; Protein Kinases |
مستخلص: | Six new C-20 and one new C-19 quassinoids, named perforalactones F-L ( 1 - 7 ), were isolated from twigs of Harrisonia perforata . Spectroscopic and X-ray crystallographic experiments were conducted to identify their structures. Through oxidative degradation of perforalactone B to perforaqussin A, the biogenetic process from C-25 quassinoid to C-20 via Baeyer-Villiger oxidation was proposed. Furthermore, the study evaluated the anti-Parkinson's disease potential of these C-20 quassinoids for the first time on 6-OHDA-induced PC12 cells and a Drosophila Parkinson's disease model of PINK1 B9 . Perforalactones G and I ( 2 and 4 ) showed a 10-15% increase in cell viability of the model cells at 50 μM, while compounds 2 and 4 (100 μM) significantly improved the climbing ability of PINK1 B9 flies and increased the dopamine level in the brains and ATP content in the thoraces of the flies. |
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معلومات مُعتمدة: | 31770392, T2192971 the natural science foundation of China; 202201AS070040 the Yunnan Provincial Science and Technology Department; P2020-KF06 the Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China; 2022ZYD0032 Sichuan Science and Technology Program; Yingtong Di Plant Doctor project |
فهرسة مساهمة: | Keywords: Harrisonia perforata; PC12 cells; PINK1B9 flies; neuroprotection; quassinoid; simarubaceae |
المشرفين على المادة: | 0 (Quassins) 0 (Plant Extracts) EC 2.7.- (Protein Kinases) |
تواريخ الأحداث: | Date Created: 20231125 Date Completed: 20231127 Latest Revision: 20231127 |
رمز التحديث: | 20231127 |
مُعرف محوري في PubMed: | PMC10671724 |
DOI: | 10.3390/ijms242216196 |
PMID: | 38003386 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1422-0067 |
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DOI: | 10.3390/ijms242216196 |