دورية أكاديمية
أعرض في EDS

Epidemiological and Genomic Analysis of Asymptomatic SARS-CoV-2 Infections during the Delta and Omicron Epidemic Waves in São Paulo City, Brazil.

التفاصيل البيبلوغرافية
العنوان: Epidemiological and Genomic Analysis of Asymptomatic SARS-CoV-2 Infections during the Delta and Omicron Epidemic Waves in São Paulo City, Brazil.
المؤلفون: Slavov SN; Center for Viral Surveillance and Serological Assessment (CeVIVAS), Butantan Institute, São Paulo 05507-000, SP, Brazil.; Ribeirão Preto Medical School, Ribeirão Preto 14051-140, SP, Brazil.; Blood Center of Ribeirão Preto, Ribeirão Preto 14051-140, SP, Brazil., Lima ARJ; Center for Viral Surveillance and Serological Assessment (CeVIVAS), Butantan Institute, São Paulo 05507-000, SP, Brazil., Ribeiro G; Center for Viral Surveillance and Serological Assessment (CeVIVAS), Butantan Institute, São Paulo 05507-000, SP, Brazil., de Lima LPO; Center for Viral Surveillance and Serological Assessment (CeVIVAS), Butantan Institute, São Paulo 05507-000, SP, Brazil., Barros CRDS; Center for Viral Surveillance and Serological Assessment (CeVIVAS), Butantan Institute, São Paulo 05507-000, SP, Brazil., Marqueze EC; Center for Viral Surveillance and Serological Assessment (CeVIVAS), Butantan Institute, São Paulo 05507-000, SP, Brazil., Martins AJ; Center for Viral Surveillance and Serological Assessment (CeVIVAS), Butantan Institute, São Paulo 05507-000, SP, Brazil., Martininghi M; Health Surveillance Coordination, Municipal Health Department of São Paulo, Coordenadoria de Vigilância em Saúde (COVISA), Secretaria Municipal de São Paulo (SMS SP), São Paulo 01223-010, SP, Brazil., Palmieri M; Health Surveillance Coordination, Municipal Health Department of São Paulo, Coordenadoria de Vigilância em Saúde (COVISA), Secretaria Municipal de São Paulo (SMS SP), São Paulo 01223-010, SP, Brazil., Caldeira LAV; Health Surveillance Coordination, Municipal Health Department of São Paulo, Coordenadoria de Vigilância em Saúde (COVISA), Secretaria Municipal de São Paulo (SMS SP), São Paulo 01223-010, SP, Brazil., Silva FEVD; Primary Care Coordination Municipal Health Department of São Paulo, Coordenadoria de Atenção Básica, Secretaria Municipal de São Paulo (SMS SP), São Paulo 01223-010, SP, Brazil., Cacherik G; Primary Care Coordination Municipal Health Department of São Paulo, Coordenadoria de Atenção Básica, Secretaria Municipal de São Paulo (SMS SP), São Paulo 01223-010, SP, Brazil., Nicolodelli AL; Primary Care Coordination Municipal Health Department of São Paulo, Coordenadoria de Atenção Básica, Secretaria Municipal de São Paulo (SMS SP), São Paulo 01223-010, SP, Brazil., Kashima S; Ribeirão Preto Medical School, Ribeirão Preto 14051-140, SP, Brazil.; Blood Center of Ribeirão Preto, Ribeirão Preto 14051-140, SP, Brazil.; University of São Paulo, Ribeirão Preto 14051-140, SP, Brazil., Giovanetti M; Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.; Institute Rene Rachou Foundation Oswaldo Cruz, Belo Horizonte 30190-002, MG, Brazil.; Sciences and Technologies for Sustainable Development and One Health, University Campus Bio-Medico Rome, 00128 Roma, Italy., Alcantara LCJ; Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.; Institute Rene Rachou Foundation Oswaldo Cruz, Belo Horizonte 30190-002, MG, Brazil., Sampaio SC; Center for Viral Surveillance and Serological Assessment (CeVIVAS), Butantan Institute, São Paulo 05507-000, SP, Brazil., Elias MC; Center for Viral Surveillance and Serological Assessment (CeVIVAS), Butantan Institute, São Paulo 05507-000, SP, Brazil.
المصدر: Viruses [Viruses] 2023 Nov 03; Vol. 15 (11). Date of Electronic Publication: 2023 Nov 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: COVID-19*/diagnosis , COVID-19*/epidemiology, Humans ; Brazil/epidemiology ; Asymptomatic Infections/epidemiology ; RNA, Viral/genetics ; SARS-CoV-2/genetics ; Genomics
مستخلص: We examined the asymptomatic rates of SARS-CoV-2 infection during the Delta and Omicron waves in the city of São Paulo. Nasopharyngeal swabs were collected at strategic points of the city (open-air markets, bus terminals, airports) for SARS-CoV-2 RNA testing. Applying the questionnaire, the symptomatic individuals were excluded, and only asymptomatic cases were analyzed. During the Delta wave, a total of 4315 samples were collected, whereas 2372 samples were collected during the first Omicron wave. The incidence of the asymptomatic SARS-CoV-2 infection was 0.6% during the Delta wave and 0.8% during the Omicron wave. No statistical differences were found in the threshold amplification cycle. However, there was a statistical difference observed in the sublineage distribution between asymptomatic and symptomatic individuals. Our study determined the incidence of asymptomatic infection by monitoring individuals who remained symptom-free, thereby providing a reliable evaluation of asymptomatic SARS-CoV-2 carriage. Our findings reveal a relatively low proportion of asymptomatic cases, which could be attributed to our rigorous monitoring protocol for the presence of clinical symptoms. Investigating asymptomatic infection rates is crucial to develop and implement effective disease control strategies.
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معلومات مُعتمدة: U01 AI151698 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Brazil; SARS-CoV-2; asymptomatic infection; epidemiology; genomic surveillance; molecular testing
المشرفين على المادة: 0 (RNA, Viral)
تواريخ الأحداث: Date Created: 20231125 Date Completed: 20231127 Latest Revision: 20240529
رمز التحديث: 20240529
مُعرف محوري في PubMed: PMC10675288
DOI: 10.3390/v15112210
PMID: 38005887
قاعدة البيانات: MEDLINE
الوصف
تدمد:1999-4915
DOI:10.3390/v15112210