دورية أكاديمية
Pyrogallol experimentally and theoretically suppressed advanced glycation end products (AGEs) formation, as one of the mechanisms involved in the chronic complications of the diabetes.
| العنوان: | Pyrogallol experimentally and theoretically suppressed advanced glycation end products (AGEs) formation, as one of the mechanisms involved in the chronic complications of the diabetes. |
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| المؤلفون: | Dorali Beni A; Department of Biology, Faculty of Basic Sciences, Lorestan University, Khorramabad 6815144316, Iran., Bahramikia S; Department of Biology, Faculty of Basic Sciences, Lorestan University, Khorramabad 6815144316, Iran. |
| المصدر: | Journal of Asian natural products research [J Asian Nat Prod Res] 2024 Jun; Vol. 26 (6), pp. 726-738. Date of Electronic Publication: 2023 Nov 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 100888334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-2213 (Electronic) Linking ISSN: 10286020 NLM ISO Abbreviation: J Asian Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: [Newark, N.J.?] : Harwood Academic Publishers, |
| مواضيع طبية MeSH: | Arginine*/*analogs & derivatives, Glycation End Products, Advanced* , Pyrogallol*/pharmacology , Pyrogallol*/chemistry , Pyrogallol*/analogs & derivatives , Arginine*/pharmacology , Arginine*/chemistry , Serum Albumin, Bovine*/chemistry , Molecular Docking Simulation*, Lysine/*analogs & derivatives , Ornithine/*analogs & derivatives, Molecular Structure ; Diabetes Complications ; Lysine/chemistry ; Lysine/pharmacology ; Animals ; Glucose ; Cattle ; Pyrimidines/pharmacology ; Pyrimidines/chemistry ; Diabetes Mellitus/drug therapy |
| مستخلص: | This study aimed to explore the inhibitory effect of pyrogallol on AGE formation in the bovine serum albumin (BSA)/glucose system for 21 days at 37 °C. The AGEs formation was measured in terms of Amadori products, total AGEs, argpyrimidine, and pentosidine. Molecular docking was used to investigate the interaction between pyrogallol and BSA. According to the results, in the presence of pyrogallol, the formation of pentosidine and argpyrimidine AGEs decreased. The molecular interaction studies demonstrated that pyrogallol has a high affinity towards arginine residues of albumin. Finally, results proved pyrogallol is a vigorous antiglycation compound and fruitful for AGE inhibition. |
| فهرسة مساهمة: | Keywords: AGEs; Amadori products; glycation; oxidative stress; pyrogallol; reactive oxygen species |
| المشرفين على المادة: | 0 (Glycation End Products, Advanced) 01Y4A2QXY0 (Pyrogallol) 94ZLA3W45F (Arginine) 27432CM55Q (Serum Albumin, Bovine) BJ4I2X2CQJ (pentosidine) K3Z4F929H6 (Lysine) IY9XDZ35W2 (Glucose) 0 (argpyrimidine) 0 (Pyrimidines) E524N2IXA3 (Ornithine) |
| تواريخ الأحداث: | Date Created: 20231125 Date Completed: 20240507 Latest Revision: 20240507 |
| رمز التحديث: | 20240507 |
| DOI: | 10.1080/10286020.2023.2283478 |
| PMID: | 38006229 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1477-2213 |
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| DOI: | 10.1080/10286020.2023.2283478 |