دورية أكاديمية
Primary cilium participates in radiation-induced bystander effects through TGF-β1 signaling.
| العنوان: | Primary cilium participates in radiation-induced bystander effects through TGF-β1 signaling. |
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| المؤلفون: | Qu P; Key Laboratory of Space Radiobiology of Gansu Province & Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; College of Life Science, University of Chinese Academy of Sciences, Beijing, China., Shao Z; Key Laboratory of Space Radiobiology of Gansu Province & Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; College of Life Science, University of Chinese Academy of Sciences, Beijing, China., Zhang Y; Key Laboratory of Space Radiobiology of Gansu Province & Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; College of Life Science, University of Chinese Academy of Sciences, Beijing, China., He J; Key Laboratory of Space Radiobiology of Gansu Province & Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; College of Life Science, University of Chinese Academy of Sciences, Beijing, China., Lu D; Key Laboratory of Space Radiobiology of Gansu Province & Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; College of Life Science, University of Chinese Academy of Sciences, Beijing, China., Wei W; Key Laboratory of Space Radiobiology of Gansu Province & Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; College of Life Science, University of Chinese Academy of Sciences, Beijing, China., Hua J; Key Laboratory of Space Radiobiology of Gansu Province & Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; College of Life Science, University of Chinese Academy of Sciences, Beijing, China., Wang W; Department of Urological Surgery, The Second Hospital of Lanzhou University, Lanzhou, China., Wang J; Key Laboratory of Space Radiobiology of Gansu Province & Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; College of Life Science, University of Chinese Academy of Sciences, Beijing, China., Ding N; Key Laboratory of Space Radiobiology of Gansu Province & Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.; College of Life Science, University of Chinese Academy of Sciences, Beijing, China. |
| المصدر: | Journal of cellular physiology [J Cell Physiol] 2024 Feb; Vol. 239 (2), pp. e31163. Date of Electronic Publication: 2023 Nov 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0050222 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4652 (Electronic) Linking ISSN: 00219541 NLM ISO Abbreviation: J Cell Physiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : Wiley-Liss Original Publication: Philadelphia, Wistar Institute of Anatomy and Biology. |
| مواضيع طبية MeSH: | Bystander Effect*/genetics , Bystander Effect*/radiation effects , Transforming Growth Factor beta1*/metabolism, Cilia/metabolism ; DNA ; RNA, Small Interfering/genetics ; Transforming Growth Factor beta/metabolism ; Humans ; Cell Line, Tumor |
| مستخلص: | Many studies have indicated that tumor growth factor-beta (TGF-β) signaling mediates radiation-induced bystander effects (RIBEs). The primary cilium (PC) coordinates several signaling pathways including TGF-β signaling to regulate diverse cellular processes. But whether the PC participates in TGF-β induced RIBEs remains unclear. The cellular levels of TGF-β1 were detected by western blot analysis and the secretion of TGF-β1 was measured by ELISA kit. The ciliogenesis was altered by CytoD treatment, STIL siRNA transfection, IFT88 siRNA transfection, or KIF3a siRNA transfection, separately, and was detected by western blot analysis and immunofluorescence staining. G (© 2023 Wiley Periodicals LLC.) |
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| معلومات مُعتمدة: | Science Fund for Distinguished Young Scholars of Gansu Province; 145RTSA012 Science and Technology Research Project of Gansu Province; 21JR7RA108 Science and Technology Research Project of Gansu Province; xbzglzb2022003 West Light Foundation of the Chinese Academy of Sciences; 12275329 National Natural Science Foundation of China; 2375355 National Natural Science Foundation of China; 12175289 National Natural Science Foundation of China |
| فهرسة مساهمة: | Keywords: DNA damages; TGF-β1; ionizing radiation; primary cilium; radiation-induced bystander effects |
| المشرفين على المادة: | 9007-49-2 (DNA) 0 (RNA, Small Interfering) 0 (Transforming Growth Factor beta) 0 (Transforming Growth Factor beta1) |
| تواريخ الأحداث: | Date Created: 20231127 Date Completed: 20240215 Latest Revision: 20240215 |
| رمز التحديث: | 20240215 |
| DOI: | 10.1002/jcp.31163 |
| PMID: | 38009273 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1097-4652 |
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| DOI: | 10.1002/jcp.31163 |