دورية أكاديمية
Prospective pilot study evaluating a vitamin D3 loading dose in critically ill children with vitamin D deficiency.
| العنوان: | Prospective pilot study evaluating a vitamin D3 loading dose in critically ill children with vitamin D deficiency. |
|---|---|
| المؤلفون: | Covington EW; Harrison College of Pharmacy, Auburn University, Auburn, Alabama, USA., Jasper-Trotter SL; Harrison College of Pharmacy, Auburn University, Auburn, Alabama, USA., Arnold RD; Harrison College of Pharmacy, Auburn University, Auburn, Alabama, USA., Amin R; Harrison College of Pharmacy, Auburn University, Auburn, Alabama, USA., Egbert S; University of Manitoba, Winnipeg, Manitoba, Canada., Chung A; Harrison College of Pharmacy, Auburn University, Auburn, Alabama, USA. |
| المصدر: | Fundamental & clinical pharmacology [Fundam Clin Pharmacol] 2024 Jun; Vol. 38 (3), pp. 588-595. Date of Electronic Publication: 2023 Nov 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Science Country of Publication: England NLM ID: 8710411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1472-8206 (Electronic) Linking ISSN: 07673981 NLM ISO Abbreviation: Fundam Clin Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2001->: Oxford : Blackwell Science Original Publication: Paris ; New York : Elsevier, c1987- |
| مواضيع طبية MeSH: | Vitamin D Deficiency*/drug therapy , Vitamin D Deficiency*/blood , Critical Illness* , Cholecalciferol*/administration & dosage , Dietary Supplements* , Intensive Care Units, Pediatric*, Humans ; Pilot Projects ; Prospective Studies ; Female ; Male ; Child ; Child, Preschool ; Infant ; Vitamin D/blood ; Vitamin D/analogs & derivatives ; Vitamin D/administration & dosage ; Adolescent ; Dose-Response Relationship, Drug ; Vitamins/administration & dosage |
| مستخلص: | Background: Vitamin D deficiency is a common finding in critically ill children. However, the optimal supplementation strategy in this patient population is unknown. The objective of this study was to evaluate the effects of high-dose (10 000 IU/kg, max. 400 000 IU) vitamin D supplementation on 25-hydroxyvitamin D3 (25[OH]D3) levels in pediatric intensive care unit (PICU) patients with baseline vitamin D deficiency. Methods: This was a prospective, institutional review board-approved pilot research study performed at the University of South Alabama Women's and Children's Hospital in Mobile, AL. The study sample consisted of patients less than 18 years old admitted to the PICU with baseline 25-hydroxyvitamin D (25[OH]D) level less than 30 ng/ml. Included patients received a one-time dose of vitamin D3 orally or via gastric tube (10 000 IU/kg, max. 400 000 IU). Results: A total of 17 patients were screened with 11 included in the study. Blood analysis revealed a significant increase in 25(OH)D3 level from baseline to 12-h post dose (21.6 [4.5] ng/ml vs. 46.7 [15.5] ng/ml, P < 0.001). At the 12-h post-dose time point, 10/11 patients (91%) had 25(OH)D3 levels that were greater than 30 ng/ml. No adverse effects were observed. Conclusion: Vitamin D3 supplementation at a dose of 10 000 IU/kg (max. 400 000 IU) significantly increased 25(OH)D3 levels in critically ill pediatric patients. (© 2023 Société Française de Pharmacologie et de Thérapeutique. Published by John Wiley & Sons Ltd.) |
| References: | McNally JD, Menon K, Chakraborty P, et al. The association of vitamin D status with pediatric critical illness. Pediatrics. 2012;130(3):429‐436. doi:10.1542/peds.2011‐3059. Amrein K, Venkatesh B. Vitamin D and the critically ill patient. Curr Opin Clin Nutr Metab Care. 2012;15(2):188‐193. doi:10.1097/MCO.0b013e32834f0027. Dang H, Li J, Liu C, Xu F. 25‐Hydroxy vitamin D deficiency is associated with cardiovascular sequential organ failure assessment and pediatric risk of mortality III scores in critically ill children. Front Pediatr. 2020;8:8. Accessed May 18, 2023. doi:10.3389/fped.2020.00066. Sankar J, Lotha W, Ismail J, Anubhuti C, Meena RS, Sankar MJ. Vitamin D deficiency and length of pediatric intensive care unit stay: a prospective observational study. Ann Intensive Care. 2016;6(1):3. doi:10.1186/s13613‐015‐0102‐8. Cariolou M, Cupp MA, Evangelou E, Tzoulaki I, Berlanga‐Taylor AJ. Importance of vitamin D in acute and critically ill children with subgroup analyses of sepsis and respiratory tract infections: a systematic review and meta‐analysis. BMJ Open. 2019;9(5):e027666. doi:10.1136/bmjopen‐2018‐027666. Madden K, Feldman HA, Smith EM, et al. Vitamin D deficiency in critically ill children. Pediatrics. 2012;130(3):421‐428. doi:10.1542/peds.2011‐3328. Ebenezer K, Job V, Antonisamy B, Dawodu A, Manivachagan MN, Steinhoff M. Serum vitamin D status and outcome among critically ill children admitted to the pediatric intensive care unit in South India. Indian J Pediatr. 2016;83(2):120‐125. doi:10.1007/s12098‐015‐1833‐0. Lee P, Nair P, Eisman JA, Center JR. Vitamin D deficiency in the intensive care unit: an invisible accomplice to morbidity and mortality? Intensive Care Med. 2009;35(12):2028‐2032. doi:10.1007/s00134‐009‐1642‐x. Holick MF, Binkley NC, Bischoff‐Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911‐1930. doi:10.1210/jc.2011‐0385. Misra M, Pacaud D, Petryk A, Collett‐Solberg PF, Kappy M, Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics. 2008;122(2):398‐417. doi:10.1542/peds.2007‐1894. Mondal K, Seth A, Marwaha RK, et al. A randomized controlled trial on safety and efficacy of single intramuscular versus staggered Oral dose of 600 000IU vitamin D in treatment of nutritional rickets. J Trop Pediatr. 2014;60(3):203‐210. doi:10.1093/tropej/fmt105. Harnot J, Verma S, Singhi S, Sankhyan N, Sachdeva N, Bharti B. Comparison of 300,000 and 600,000 IU Oral vitamin‐D bolus for vitamin‐D deficiency in young children. Indian J Pediatr. 2017;84(2):111‐116. doi:10.1007/s12098‐016‐2233‐9. Ataide FL, Carvalho Bastos LM, Vicente Matias MF, Skare TL, Freire de Carvalho J. Safety and effectiveness of vitamin D mega‐dose: a systematic review. Clin Nutr ESPEN. 2021;46:115‐120. doi:10.1016/j.clnesp.2021.09.010. Klein GL, Herndon DN, Chen TC, Kulp G, Holick MF. Standard multivitamin supplementation does not improve vitamin D insufficiency after burns. J Bone Miner Metab. 2009;27(4):502‐506. doi:10.1007/s00774‐009‐0065‐7. McNally JD, Iliriani K, Pojsupap S, et al. Rapid normalization of vitamin D levels: a meta‐analysis. Pediatrics. 2015;135(1):e152‐e166. doi:10.1542/peds.2014‐1703. O'Hearn K, Menon K, Weiler HA, et al. A phase II dose evaluation pilot feasibility randomized controlled trial of cholecalciferol in critically ill children with vitamin D deficiency (VITdAL‐PICU study). BMC Pediatr. 2023;23(1):397. doi:10.1186/s12887‐023‐04205‐9. Daley T, Hughan K, Rayas M, Kelly A, Tangpricha V. Vitamin D deficiency and its treatment in cystic fibrosis. J Cyst Fibros. 2019;18:S66‐S73. doi:10.1016/j.jcf.2019.08.022. Balachandar R, Pullakhandam R, Kulkarni B, Sachdev HS. Relative efficacy of vitamin D2 and vitamin D3 in improving vitamin D status: systematic review and meta‐analysis. Nutrients. 2021;13(10):3328. doi:10.3390/nu13103328. Alayed Albarri EM, Sameer Alnuaimi A, Abdelghani D. Effectiveness of vitamin D2 compared with vitamin D3 replacement therapy in a primary healthcare setting: a retrospective cohort study. Qatar Med J. 2022;2022(3):29. doi:10.5339/qmj.2022.35. Casey CF, Slawson DC, Neal LR. Vitamin D supplementation in infants, children, and adolescents. Am Fam Physician. 2010;81(6):745‐748. Lee JY, So TY, Thackray J. A review on vitamin D deficiency treatment in pediatric patients. J Pediatr Pharmacol Ther JPPT. 2013;18(4):277‐291. doi:10.5863/1551‐6776‐18.4.277. Heaney RP, Recker RR, Grote J, Horst RL, Armas LAG. Vitamin D(3) is more potent than vitamin D(2) in humans. J Clin Endocrinol Metab. 2011;96(3):E447‐E452. doi:10.1210/jc.2010‐2230. Armas LAG, Hollis BW, Heaney RP. Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004;89(11):5387‐5391. doi:10.1210/jc.2004‐0360. McNally JD, Nama N, O'Hearn K, et al. Vitamin D deficiency in critically ill children: a systematic review and meta‐analysis. Crit Care Lond Engl. 2017;21(1):287. doi:10.1186/s13054‐017‐1875‐y. Gottschlich MM, Mayes T, Khoury J, Kagan RJ. Clinical trial of vitamin D2 vs D3 supplementation in critically ill pediatric burn patients. JPEN J Parenter Enteral Nutr. 2017;41(3):412‐421. doi:10.1177/0148607115587948. Forno E, Bacharier LB, Phipatanakul W, et al. Effect of vitamin D3 supplementation on severe asthma exacerbations in children with asthma and low vitamin D levels: the VDKA randomized clinical trial. Jama. 2020;324(8):752‐760. doi:10.1001/jama.2020.12384. Holmlund‐Suila E, Viljakainen H, Hytinantti T, Lamberg‐Allardt C, Andersson S, Mäkitie O. High‐dose vitamin d intervention in infants—effects on vitamin d status, calcium homeostasis, and bone strength. J Clin Endocrinol Metab. 2012;97(11):4139‐4147. doi:10.1210/jc.2012‐1575. Aristizabal N, Holder MP, Durham L, Ashraf AP, Taylor S, Salas AA. Safety and efficacy of early vitamin D supplementation in critically ill extremely preterm infants: an ancillary study of a randomized trial. J Acad Nutr Diet. 2023;123(1):87‐94. doi:10.1016/j.jand.2022.06.012. Chowdhury F, Shahid ASMSB, Tabassum M, et al. Vitamin D supplementation among Bangladeshi children under‐five years of age hospitalised for severe pneumonia: a randomised placebo controlled trial. PLoS ONE. 2021;16(2):e0246460. doi:10.1371/journal.pone.0246460. Gordon CM, Williams AL, Feldman HA, et al. Treatment of hypovitaminosis D in infants and toddlers. J Clin Endocrinol Metab. 2008;93(7):2716‐2721. doi:10.1210/jc.2007‐2790. Lu H, Rosenbaum S. Developmental pharmacokinetics in pediatric populations. J Pediatr Pharmacol Ther JPPT. 2014;19(4):262‐276. doi:10.5863/1551‐6776‐19.4.262. Carvalho AC, Santos NC, Portugal‐Nunes C, et al. 25‐OH vitamin D levels and cognitive performance: longitudinal assessment in a healthy aging cohort. Front Aging Neurosci. 2019;11:11. Accessed July 20, 2023. doi:10.3389/fnagi.2019.00330. |
| معلومات مُعتمدة: | RI Futures Grant American College of Clinical Pharmacy; Gateway to Research Scholarship American Foundation for Pharmaceutical Education |
| فهرسة مساهمة: | Keywords: cholecalciferol; critical illness; pediatrics; vitamin D; vitamin D deficiency |
| المشرفين على المادة: | 1C6V77QF41 (Cholecalciferol) 1406-16-2 (Vitamin D) A288AR3C9H (25-hydroxyvitamin D) 0 (Vitamins) |
| تواريخ الأحداث: | Date Created: 20231127 Date Completed: 20240514 Latest Revision: 20240514 |
| رمز التحديث: | 20240514 |
| DOI: | 10.1111/fcp.12973 |
| PMID: | 38010094 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1472-8206 |
|---|---|
| DOI: | 10.1111/fcp.12973 |