دورية أكاديمية
Heart failure 'the cancer of the heart': the prognostic role of the HLM score.
| العنوان: | Heart failure 'the cancer of the heart': the prognostic role of the HLM score. |
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| المؤلفون: | Severino P; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, Rome, Italy., Mancone M; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, Rome, Italy., D'Amato A; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, Rome, Italy., Mariani MV; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, Rome, Italy., Prosperi S; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, Rome, Italy., Alunni Fegatelli D; Department of Public Health and Infectious Disease, Sapienza University of Rome, Rome, Italy., Birtolo LI; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, Rome, Italy., Angotti D; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, Rome, Italy., Milanese A; Department of Public Health and Infectious Disease, Sapienza University of Rome, Rome, Italy., Cerrato E; Interventional Cardiology Unit, San Luigi Gonzaga University Hospital, Orbassano and Rivoli Infermi Hospital, Rivoli (Turin), Italy., Maestrini V; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, Rome, Italy., Pizzi C; Department of Experimental, Diagnostic and Specialty Medicine-DIMES, University of Bologna, IRCCS Sant'Orsola-Malpighi Hospital, Bologna, Italy., Foà A; Department of Experimental, Diagnostic and Specialty Medicine-DIMES, University of Bologna, IRCCS Sant'Orsola-Malpighi Hospital, Bologna, Italy., Vestri A; Department of Public Health and Infectious Disease, Sapienza University of Rome, Rome, Italy., Palazzuoli A; Cardiovascular Diseases Unit, Le Scotte Hospital, University of Siena, Siena, Italy., Vizza CD; Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, Rome, Italy., Casale PN; Department of Cardiology and Population Health Sciences, Weill Cornell Medical College, New York, NY, USA., Mather PJ; Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, PA, USA., Fedele F; IRCCS San Raffaele Cassino, Cassino, Italy. |
| المصدر: | ESC heart failure [ESC Heart Fail] 2024 Feb; Vol. 11 (1), pp. 390-399. Date of Electronic Publication: 2023 Nov 27. |
| نوع المنشور: | Journal Article; Multicenter Study; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley & Sons Ltd on behalf of the European Society of Cardiology Country of Publication: England NLM ID: 101669191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2055-5822 (Electronic) Linking ISSN: 20555822 NLM ISO Abbreviation: ESC Heart Fail Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Oxford] : John Wiley & Sons Ltd on behalf of the European Society of Cardiology, [2014]- |
| مواضيع طبية MeSH: | Heart Failure*/diagnosis , Heart Failure*/epidemiology , Neoplasms*, Female ; Humans ; Male ; Prognosis ; Prospective Studies ; Stroke Volume ; United States ; Ventricular Function, Left ; Middle Aged ; Aged ; Aged, 80 and over |
| مستخلص: | Aims: The multi-systemic effects of heart failure (HF) resemble the spread observed during cancer. We propose a new score, named HLM, analogous to the TNM classification used in oncology, to assess the prognosis of HF. HLM refers to H: heart damage, L: lung involvement, and M: systemic multiorgan involvement. The aim was to compare the HLM score to the conventional New York Heart Association (NYHA) classification, American College of Cardiology/American Heart Association (ACC/AHA) stages, and left ventricular ejection fraction (LVEF), to assess the most accurate prognostic tool for HF patients. Methods and Results: We performed a multicentre, observational, prospective study of consecutive patients admitted for HF. Heart, lung, and other organ function parameters were collected. Each patient was classified according to the HLM score, NYHA classification, ACC/AHA stages, and LVEF assessed by transthoracic echocardiography. The follow-up period was 12 months. The primary endpoint was a composite of all-cause death and rehospitalization due to HF. A total of 1720 patients who completed the 12 month follow-up period have been enrolled in the study. 520 (30.2%) patients experienced the composite endpoint of all-cause death and rehospitalization due to HF. 540 (31.4%) patients were female. The mean age of the study population was 70.5 ± 12.9. The mean LVEF at admission was 42.5 ± 13%. Regarding the population distribution across the spectrum of HLM score stages, 373 (21.7%) patients were included in the HLM-1, 507 (29.5%) in the HLM-2, 587 (34.1%) in the HLM-3, and 253 (14.7%) in the HLM-4. HLM was the most accurate score to predict the primary endpoint at 12 months. The area under the receiver operating characteristic curve (AUC) was greater for the HLM score compared with the NYHA classification, ACC/AHA stages, or LVEF, regarding the composite endpoint (HLM = 0.645; NYHA = 0.580; ACC/AHA = 0.589; LVEF = 0.572). The AUC of the HLM score was significantly better compared with the LVEF (P = 0.002), ACC/AHA (P = 0.029), and NYHA (P = 0.009) AUC. Conclusions: The HLM score has a greater prognostic power compared with the NYHA classification, ACC/AHA stages, and LVEF assessed by transthoracic echocardiography in terms of the composite endpoint of all-cause death and rehospitalization due to HF at 12 months of follow-up. (© 2023 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.) |
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| فهرسة مساهمة: | Keywords: All-cause mortality; HLM score; Heart failure; Prognosis; Rehospitalization |
| تواريخ الأحداث: | Date Created: 20231127 Date Completed: 20240202 Latest Revision: 20240202 |
| رمز التحديث: | 20240202 |
| مُعرف محوري في PubMed: | PMC10804198 |
| DOI: | 10.1002/ehf2.14594 |
| PMID: | 38011913 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2055-5822 |
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| DOI: | 10.1002/ehf2.14594 |