Lesions to different regions of frontal cortex have dissociable effects on voluntary persistence.
| العنوان: | Lesions to different regions of frontal cortex have dissociable effects on voluntary persistence. |
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| المؤلفون: | van Geen C; Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104., Chen Y; Department of Psychological and Brain Sciences, Boston University, Boston, MA 02215., Kazinka R; Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN 55455., Vaidya AR; NIDA Intramural Research Program, Baltimore, MD 21224., Kable JW; Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104., McGuire JT; Department of Psychological and Brain Sciences, Boston University, Boston, MA 02215. |
| المصدر: | BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 17. Date of Electronic Publication: 2023 Nov 17. |
| نوع المنشور: | Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: | Deciding how long to keep waiting for uncertain future rewards is a complex problem. Previous research has shown that choosing to stop waiting results from an evaluative process that weighs the subjective value of the awaited reward against the opportunity cost of waiting. In functional neuroimaging data, activity in ventromedial prefrontal cortex (vmPFC) tracks the dynamics of this evaluation, while activation in the dorsomedial prefrontal cortex (dmPFC) and anterior insula (AI) ramps up before a decision to quit is made. Here, we provide causal evidence of the necessity of these brain regions for successful performance in a willingness-to-wait task. 28 participants with frontal lobe lesions were tested on their ability to adaptively calibrate how long they waited for monetary rewards. We grouped the participants based on the location of their lesions, which were primarily in ventromedial, dorsomedial, or lateral parts of their prefrontal cortex (vmPFC, dmPFC, and lPFC, respectively), or in the anterior insula. We compared the performance of each subset of lesion participants to behavior in a control group without lesions (n=18). Finally, we fit a newly developed computational model to the data to glean a more mechanistic understanding of how lesions affect the cognitive processes underlying choice. We found that participants with lesions to the vmPFC waited less overall, while participants with lesions to the dmPFC and anterior insula were specifically impaired at calibrating their level of persistence to the environment. These behavioral effects were accounted for by systematic differences in parameter estimates from a computational model of task performance: while the vmPFC group showed reduced initial willingness to wait, lesions to the dmPFC/anterior insula were associated with slower learning from negative feedback. These findings corroborate the notion that failures of persistence can be driven by sophisticated cost-benefit analyses rather than lapses in self-control. They also support the functional specialization of different parts of the prefrontal cortex in service of voluntary persistence. |
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| معلومات مُعتمدة: | F32 DA030870 United States DA NIDA NIH HHS; R01 DA029149 United States DA NIDA NIH HHS; R21 MH124095 United States MH NIMH NIH HHS; ZIA DA000642 United States ImNIH Intramural NIH HHS |
| فهرسة مساهمة: | Keywords: brain lesions; decision-making; willingness to wait |
| تواريخ الأحداث: | Date Created: 20231128 Latest Revision: 20231214 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10680867 |
| DOI: | 10.1101/2023.11.16.567406 |
| PMID: | 38014017 |
| قاعدة البيانات: | MEDLINE |
| DOI: | 10.1101/2023.11.16.567406 |
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