التفاصيل البيبلوغرافية
| العنوان: |
Sleep Disruption in a Mouse Model of Chronic Traumatic Brain Injury. |
| المؤلفون: |
Morris AR, Gudenschwager Basso EK, Gutierrez-Monreal MA, Arja RD, Kobeissy FH, Janus CG, Wang KKW, Zhu J, Liu AC |
| المصدر: |
BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 14. Date of Electronic Publication: 2023 Nov 14. |
| نوع المنشور: |
Preprint |
| اللغة: |
English |
| بيانات الدورية: |
Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: |
Chronic sleep/wake disturbances are strongly associated with traumatic brain injury (TBI) in patients and are being increasingly recognized. However, the underlying mechanisms are largely understudied and there is an urgent need for animal models of lifelong sleep/wake disturbances. The objective of this study was to develop a chronic TBI rodent model and investigate the lifelong chronic effect of TBI on sleep/wake behavior. We performed repetitive midline fluid percussion injury (rmFPI) in four months old mice and monitored their sleep/wake behavior using the non-invasive PiezoSleep system. The sleep/wake states were recorded before injury (baseline) and then monthly thereafter. We found that TBI mice displayed a significant decrease in sleep duration in both the light and dark phases, beginning at three months post-TBI and continuing throughout the study. Consistent with the sleep phenotype, these TBI mice showed circadian locomotor activity phenotypes and exhibited reduced anxiety-like behavior. TBI mice also gained less weight, and had less lean mass and total body water content, compared to sham controls. Furthermore, TBI mice showed extensive brain tissue loss and increased GFAP and IBA1 levels in the hypothalamus and the vicinity of the injury, indicative of chronic neuropathology. In summary, our study identified a critical time window of TBI pathology and associated circadian and sleep/wake phenotypes. Future studies should leverage this mouse model to investigate the molecular mechanisms underlying the chronic sleep/wake phenotypes following TBI early in life. |
| التعليقات: |
Update in: Neurotrauma Rep. 2024 Jan 19;5(1):61-73. (PMID: 38288298) |
| تواريخ الأحداث: |
Date Created: 20231128 Latest Revision: 20240212 |
| رمز التحديث: |
20240212 |
| مُعرف محوري في PubMed: |
PMC10680804 |
| DOI: |
10.1101/2023.11.10.566553 |
| PMID: |
38014315 |
| قاعدة البيانات: |
MEDLINE |
