دورية أكاديمية
أعرض في EDS

PD-1 Impairs CD8+ T Cell Granzyme B Production in Aged Mice during Acute Viral Respiratory Infection.

التفاصيل البيبلوغرافية
العنوان: PD-1 Impairs CD8+ T Cell Granzyme B Production in Aged Mice during Acute Viral Respiratory Infection.
المؤلفون: Parks OB; Division of Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA., Antos D; Division of Pulmonology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA., Eddens T; Division of Allergy/Immunology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA., Walters S; Division of Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA., Johnson M; Division of Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA., Oury TD; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA., Gottschalk RA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA., Erickson JJ; Division of Neonatology and Pulmonary Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH., Williams JV; Division of Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA.; Institute for Infection, Inflammation, and Immunity in Children (i4Kids), Pittsburgh, PA.
المصدر: ImmunoHorizons [Immunohorizons] 2023 Nov 01; Vol. 7 (11), pp. 771-787.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Association of Immunologists, Inc Country of Publication: United States NLM ID: 101708159 Publication Model: Print Cited Medium: Internet ISSN: 2573-7732 (Electronic) Linking ISSN: 25737732 NLM ISO Abbreviation: Immunohorizons Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Rockville, Maryland : American Association of Immunologists, Inc., [2017]-
مواضيع طبية MeSH: Respiratory Tract Infections* , Virus Diseases*, Animals ; Humans ; Mice ; CD8-Positive T-Lymphocytes ; Granzymes ; Immune Checkpoint Inhibitors ; Programmed Cell Death 1 Receptor
مستخلص: CD8+ T cell dysfunction contributes to severe respiratory viral infection outcomes in older adults. CD8+ T cells are the primary cell type responsible for viral clearance. With increasing age, CD8+ T cell function declines in conjunction with an accumulation of cytotoxic tissue-resident memory (TRM) CD8+ T cells. We sought to elucidate the role of PD-1 signaling on aged CD8+ T cell function and accumulation of CD8+ TRM cells during acute viral respiratory tract infection, given the importance of PD-1 regulating CD8+ T cells during acute and chronic infections. PD-1 blockade or genetic ablation in aged mice yielded improved CD8+ T cell granzyme B production comparable to that in young mice during human metapneumovirus and influenza viral infections. Syngeneic transplant and adoptive transfer strategies revealed that improved granzyme B production in aged Pdcd1-/- CD8+ T cells was primarily cell intrinsic because aged wild-type CD8+ T cells did not have increased granzyme B production when transplanted into a young host. PD-1 signaling promoted accumulation of cytotoxic CD8+ TRM cells in aged mice. PD-1 blockade of aged mice during rechallenge infection resulted in improved clinical outcomes that paralleled reduced accumulation of CD8+ TRM cells. These findings suggest that PD-1 signaling impaired CD8+ T cell granzyme B production and contributed to CD8+ TRM cell accumulation in the aged lung. These findings have implications for future research investigating PD-1 checkpoint inhibitors as a potential therapeutic option for elderly patients with severe respiratory viral infections.
(Copyright © 2023 The Authors.)
References: Immun Ageing. 2023 Aug 1;20(1):40. (PMID: 37528458)
J Infect Dis. 2012 Jul 1;206(1):56-62. (PMID: 22529314)
Immunohorizons. 2023 Jun 1;7(6):398-411. (PMID: 37261717)
Sci Transl Med. 2021 Oct 13;13(615):eaba6006. (PMID: 34644150)
Front Immunol. 2020 Nov 11;11:585168. (PMID: 33262764)
Pediatr Infect Dis J. 2004 Jan;23(1 Suppl):S25-32. (PMID: 14730267)
J Clin Invest. 2016 Aug 1;126(8):3130-44. (PMID: 27454297)
F1000Res. 2018 Feb 1;7:135. (PMID: 29744035)
Immunohorizons. 2021 Jul 15;5(7):543-556. (PMID: 34266962)
J Clin Invest. 2012 Aug;122(8):2967-82. (PMID: 22797302)
Front Immunol. 2018 Oct 17;9:2374. (PMID: 30386337)
Nat Rev Endocrinol. 2018 Oct;14(10):576-590. (PMID: 30046148)
J Immunol. 2015 Nov 1;195(9):4319-30. (PMID: 26401005)
Arch Immunol Ther Exp (Warsz). 2016 Apr;64(2):111-26. (PMID: 26658771)
Front Immunol. 2018 Dec 18;9:2981. (PMID: 30619337)
N Engl J Med. 2018 Aug 30;379(9):e14. (PMID: 30157404)
Nature. 2022 Oct;610(7930):173-181. (PMID: 36171288)
mBio. 2020 Sep 18;11(5):. (PMID: 32948688)
J Infect Dis. 2003 Mar 1;187(5):785-90. (PMID: 12599052)
Nat Immunol. 2019 Mar;20(3):326-336. (PMID: 30778252)
J Virol. 2013 Dec;87(23):12916-24. (PMID: 24067957)
J Virol Methods. 2018 Sep;259:1-9. (PMID: 29807042)
Proc Natl Acad Sci U S A. 2018 May 1;115(18):4749-4754. (PMID: 29654146)
Nat Biotechnol. 2018 Oct;36(9):847-856. (PMID: 30102295)
J Exp Med. 2015 Jun 29;212(7):1125-37. (PMID: 26034050)
J Virol. 2015 Apr;89(8):4405-20. (PMID: 25653440)
Front Aging. 2021;2:. (PMID: 35441156)
Clin Chest Med. 2017 Mar;38(1):29-36. (PMID: 28159159)
J Biosci. 2012 Mar;37(1):55-62. (PMID: 22357203)
Sci Immunol. 2019 Jun 14;4(36):. (PMID: 31201259)
Vaccine. 2010 Feb 10;28(6):1477-80. (PMID: 20003919)
Cell Rep. 2020 Jun 30;31(13):107827. (PMID: 32610128)
J Crit Care. 2016 Feb;31(1):233-7. (PMID: 26572580)
Sci Immunol. 2022 Aug 5;7(74):eabj9123. (PMID: 35930654)
J Virol. 2005 Sep;79(17):10944-51. (PMID: 16103146)
J Immunol. 2016 Jul 1;197(1):233-43. (PMID: 27259857)
Front Aging. 2022 Apr 27;3:848925. (PMID: 35821822)
Nature. 2016 Sep 15;537(7620):417-421. (PMID: 27501248)
Curr Top Microbiol Immunol. 2013;372:211-31. (PMID: 24362692)
J Virol. 2008 Sep;82(17):8560-9. (PMID: 18562525)
J Immunol. 2018 Aug 15;201(4):1253-1266. (PMID: 29997123)
Sci Immunol. 2020 Nov 6;5(53):. (PMID: 33158975)
Immunology. 2003 Apr;108(4):474-80. (PMID: 12667209)
Proc Natl Acad Sci U S A. 2019 May 14;116(20):9999-10008. (PMID: 31028147)
Cancer Med. 2021 Feb;10(4):1222-1239. (PMID: 33465302)
Mech Ageing Dev. 2002 Apr 30;123(8):1167-81. (PMID: 12044966)
J Immunol. 2014 Nov 15;193(10):5108-17. (PMID: 25339663)
Immunity. 2021 Jan 12;54(1):99-115.e12. (PMID: 33271118)
J Virol. 2005 May;79(10):5971-8. (PMID: 15857983)
Immunology. 1991 Apr;72(4):514-9. (PMID: 2037313)
J Immunother Cancer. 2018 Apr 4;6(1):26. (PMID: 29618381)
معلومات مُعتمدة: 75N92020D00005 United States HL NHLBI NIH HHS; R01 AI085062 United States AI NIAID NIH HHS; F30 HL159915 United States HL NHLBI NIH HHS; 75N93022D00005 United States AI NIAID NIH HHS; F31 HL164031 United States HL NHLBI NIH HHS; K12 HD000850 United States HD NICHD NIH HHS; T32 GM008208 United States GM NIGMS NIH HHS; 75N95020D00005 United States DA NIDA NIH HHS; 75N99020D00005 United States OF ORFDO NIH HHS; 75N93023D00005 United States AI NIAID NIH HHS
المشرفين على المادة: EC 3.4.21.- (Granzymes)
0 (Immune Checkpoint Inhibitors)
0 (Programmed Cell Death 1 Receptor)
تواريخ الأحداث: Date Created: 20231128 Date Completed: 20231201 Latest Revision: 20240822
رمز التحديث: 20240822
مُعرف محوري في PubMed: PMC10696419
DOI: 10.4049/immunohorizons.2300094
PMID: 38015461
قاعدة البيانات: MEDLINE
الوصف
تدمد:2573-7732
DOI:10.4049/immunohorizons.2300094