دورية أكاديمية
أعرض في EDS

Spared nerve injury decreases motivation in long-access homecage-based operant tasks in mice.

التفاصيل البيبلوغرافية
العنوان: Spared nerve injury decreases motivation in long-access homecage-based operant tasks in mice.
المؤلفون: Norris MR; Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO, United States.; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO, United States.; Center for Clinical Pharmacology, St. Louis College of Pharmacy and Washington University School of Medicine, St. Louis, MO, United States.; Washington University Pain Center, Washington University in St. Louis, St. Louis, MO, United States.; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, United States., Becker LJ; Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO, United States.; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO, United States.; Center for Clinical Pharmacology, St. Louis College of Pharmacy and Washington University School of Medicine, St. Louis, MO, United States.; Washington University Pain Center, Washington University in St. Louis, St. Louis, MO, United States., Bilbily J; Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO, United States.; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO, United States.; Center for Clinical Pharmacology, St. Louis College of Pharmacy and Washington University School of Medicine, St. Louis, MO, United States.; Washington University Pain Center, Washington University in St. Louis, St. Louis, MO, United States.; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, United States., Chang YH; Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO, United States.; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO, United States.; Center for Clinical Pharmacology, St. Louis College of Pharmacy and Washington University School of Medicine, St. Louis, MO, United States.; Washington University Pain Center, Washington University in St. Louis, St. Louis, MO, United States.; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, United States., Borges G; Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO, United States.; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO, United States.; Center for Clinical Pharmacology, St. Louis College of Pharmacy and Washington University School of Medicine, St. Louis, MO, United States.; Washington University Pain Center, Washington University in St. Louis, St. Louis, MO, United States., Dunn SS; Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO, United States.; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO, United States.; Center for Clinical Pharmacology, St. Louis College of Pharmacy and Washington University School of Medicine, St. Louis, MO, United States.; Washington University Pain Center, Washington University in St. Louis, St. Louis, MO, United States.; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, United States., Madasu MK; Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO, United States.; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO, United States.; Center for Clinical Pharmacology, St. Louis College of Pharmacy and Washington University School of Medicine, St. Louis, MO, United States.; Washington University Pain Center, Washington University in St. Louis, St. Louis, MO, United States., Vazquez CR; Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO, United States.; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO, United States.; Center for Clinical Pharmacology, St. Louis College of Pharmacy and Washington University School of Medicine, St. Louis, MO, United States.; Washington University Pain Center, Washington University in St. Louis, St. Louis, MO, United States.; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, United States., Cariello SA; Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO, United States.; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO, United States.; Center for Clinical Pharmacology, St. Louis College of Pharmacy and Washington University School of Medicine, St. Louis, MO, United States.; Washington University Pain Center, Washington University in St. Louis, St. Louis, MO, United States., Al-Hasani R; Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO, United States.; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO, United States.; Center for Clinical Pharmacology, St. Louis College of Pharmacy and Washington University School of Medicine, St. Louis, MO, United States.; Washington University Pain Center, Washington University in St. Louis, St. Louis, MO, United States.; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, United States., Creed MC; Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO, United States.; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO, United States.; Center for Clinical Pharmacology, St. Louis College of Pharmacy and Washington University School of Medicine, St. Louis, MO, United States.; Washington University Pain Center, Washington University in St. Louis, St. Louis, MO, United States.; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, United States.; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, United States., McCall JG; Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO, United States.; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO, United States.; Center for Clinical Pharmacology, St. Louis College of Pharmacy and Washington University School of Medicine, St. Louis, MO, United States.; Washington University Pain Center, Washington University in St. Louis, St. Louis, MO, United States.; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, United States.
المصدر: Pain [Pain] 2024 Jun 01; Vol. 165 (6), pp. 1247-1265. Date of Electronic Publication: 2023 Nov 27.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7508686 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6623 (Electronic) Linking ISSN: 03043959 NLM ISO Abbreviation: Pain Subsets: MEDLINE
أسماء مطبوعة: Publication: 2015- : Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: Amsterdam, Elsevier/North-Holland.
مواضيع طبية MeSH: Motivation*/physiology , Conditioning, Operant*/physiology , Mice, Inbred C57BL*, Animals ; Mice ; Male ; Female ; Neuralgia/psychology ; Neuralgia/etiology ; Neuralgia/physiopathology ; Disease Models, Animal ; Reward ; Adaptation, Psychological/physiology
مستخلص: Abstract: Neuropathic pain causes both sensory and emotional maladaptation. Preclinical animal studies of neuropathic pain-induced negative affect could result in novel insights into the mechanisms of chronic pain. Modeling pain-induced negative affect, however, is variable across research groups and conditions. The same injury may or may not produce robust negative affective behavioral responses across different species, strains, and laboratories. Here, we sought to identify negative affective consequences of the spared nerve injury model on C57BL/6J male and female mice. We found no significant effect of spared nerve injury across a variety of approach-avoidance conflict, hedonic choice, and coping strategy assays. We hypothesized these inconsistencies may stem in part from the short test duration of these assays. To test this hypothesis, we used the homecage-based Feeding Experimentation Device version 3 to conduct 12-hour, overnight progressive ratio testing to determine whether mice with chronic spared nerve injury had decreased motivation to earn palatable food rewards. Our data demonstrate that despite equivalent task learning, spared nerve injury mice are less motivated to work for a sugar pellet than sham controls. Furthermore, when we normalized behavioral responses across all the behavioral assays we tested, we found that a combined normalized behavioral score is predictive of injury state and significantly correlates with mechanical thresholds. Together, these results suggest that homecage-based operant behaviors provide a useful platform for modeling nerve injury-induced negative affect and that valuable pain-related information can arise from agglomerative data analyses across behavioral assays-even when individual inferential statistics do not demonstrate significant mean differences.
(Copyright © 2023 International Association for the Study of Pain.)
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معلومات مُعتمدة: R01 DA058755 United States DA NIDA NIH HHS; R01 NS117899 United States NS NINDS NIH HHS; R01DA049924 United States DA NIDA NIH HHS; T32DA007261 United States DA NIDA NIH HHS; R01NS117899 United States NS NINDS NIH HHS; R01DA058755 United States DA NIDA NIH HHS; R01NS123070 United States NS NINDS NIH HHS; F31NS124301 United States NS NINDS NIH HHS; F31 NS124301 United States NS NINDS NIH HHS; R01 DA049924 United States DA NIDA NIH HHS; R01 NS123070 United States NS NINDS NIH HHS; T32 DA007261 United States DA NIDA NIH HHS
تواريخ الأحداث: Date Created: 20231128 Date Completed: 20240513 Latest Revision: 20240517
رمز التحديث: 20240517
مُعرف محوري في PubMed: PMC11095834
DOI: 10.1097/j.pain.0000000000003123
PMID: 38015628
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-6623
DOI:10.1097/j.pain.0000000000003123