دورية أكاديمية
Regulatory T-cell phenotypes in prenatal psychological distress.
| العنوان: | Regulatory T-cell phenotypes in prenatal psychological distress. |
|---|---|
| المؤلفون: | Wiley KS; Department of Anthropology, University of California, Los Angeles, United States; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, United States. Electronic address: kyleswiley@ucla.edu., Kwon D; Department of Epidemiology, UCLA Fielding School of Public Health, University of California, Los Angeles, United States., Knorr DA; Department of Anthropology, University of California, Los Angeles, United States., Fox MM; Department of Anthropology, University of California, Los Angeles, United States; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, United States. |
| المصدر: | Brain, behavior, and immunity [Brain Behav Immun] 2024 Feb; Vol. 116, pp. 62-69. Date of Electronic Publication: 2023 Nov 26. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2000- > : Amsterdam : Elsevier Original Publication: San Diego : Academic Press, [c1987- |
| مواضيع طبية MeSH: | T-Lymphocytes, Regulatory* , Programmed Cell Death 1 Receptor*, Pregnancy ; Humans ; Female ; Flow Cytometry ; Biomarkers ; Phenotype ; Forkhead Transcription Factors ; Stress, Psychological |
| مستخلص: | Background: Experiencing symptoms of psychological distress during pregnancy is common and has been linked to dysregulated immune functioning. In this context, immunoregulatory function is especially relevant because of its crucial role in establishment and maintenance of healthy pregnancy. However, little research has examined associations between women's prenatal psychological distress and immunoregulatory biomarkers. We investigated how symptoms of depression, anxiety, and stress relate to circulating levels of regulatory T-cells (Tregs). Materials and Methods: Pregnant Latina women were assessed at around 12 weeks of pregnancy (N = 82). These assessments included blood draws and self-report questionnaires assessing symptoms of depression, state anxiety, pregnancy-related anxiety, and perceived stress. Flow cytometry on PBMCs was used to quantify circulating Tregs, defined as CD3 + CD4 + CD25 hi CD127 lo FoxP3 + , and subpopulations positive for one of the following intra- or extracellular markers, CD45RA, CTLA-4, Helios, PD-1, TIM-3, and TIGIT. We collected 82 samples at 12 weeks. Multivariable linear regressions tested for associations between symptoms of psychological distress and Treg concentrations, adjusted for gestational age. Results: State anxiety symptoms at 12 weeks were negatively associated with parent Treg cell levels (b = -4.02, p = 0.023) and subpopulations Helios + (b = -3.29, p = 0.019) and TIM3 + (b = -3.17, p = 0.008). Perceived stress was negatively associated with the PD-1 + subpopulation at 12 weeks (b = -4.02, p = 0.023). Depression was not related to Tregs or the subpopulations. Conclusion: Our observation that symptoms of anxiety and stress are related to tolerogenic immunology suggests a possible biomechanism explaining correlations of maternal mood disorders with adverse outcomes for mothers and offspring. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Published by Elsevier Inc.) |
| معلومات مُعتمدة: | K01 DK105110 United States DK NIDDK NIH HHS; R03 DK125524 United States DK NIDDK NIH HHS; F32 MD015201 United States MD NIMHD NIH HHS |
| فهرسة مساهمة: | Keywords: Anxiety; Depression; Pregnancy; Prenatal mood; Regulatory T-cells; Stress |
| المشرفين على المادة: | 0 (Programmed Cell Death 1 Receptor) 0 (Biomarkers) 0 (Forkhead Transcription Factors) |
| تواريخ الأحداث: | Date Created: 20231128 Date Completed: 20240122 Latest Revision: 20240307 |
| رمز التحديث: | 20240308 |
| DOI: | 10.1016/j.bbi.2023.11.033 |
| PMID: | 38016492 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1090-2139 |
|---|---|
| DOI: | 10.1016/j.bbi.2023.11.033 |